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Gene: EHBP1 |
Gene summary for EHBP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | EHBP1 | Gene ID | 23301 |
Gene name | EH domain binding protein 1 | |
Gene Alias | HPC12 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A140VK17 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23301 | EHBP1 | CCI_1 | Human | Cervix | CC | 1.79e-17 | 1.14e+00 | 0.528 |
23301 | EHBP1 | CCI_2 | Human | Cervix | CC | 1.69e-13 | 1.25e+00 | 0.5249 |
23301 | EHBP1 | CCI_3 | Human | Cervix | CC | 1.34e-21 | 1.24e+00 | 0.516 |
23301 | EHBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.52e-08 | -4.70e-01 | 0.0155 |
23301 | EHBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.79e-06 | -4.96e-01 | -0.1808 |
23301 | EHBP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.00e-07 | -5.47e-01 | -0.1207 |
23301 | EHBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.85e-17 | -5.76e-01 | -0.1464 |
23301 | EHBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.29e-05 | -3.77e-01 | -0.1001 |
23301 | EHBP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.60e-03 | -6.61e-01 | -0.1706 |
23301 | EHBP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.38e-05 | -8.01e-01 | -0.2061 |
23301 | EHBP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.73e-02 | -4.76e-01 | -0.0842 |
23301 | EHBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.00e-08 | -5.22e-01 | 0.096 |
23301 | EHBP1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.58e-05 | -4.27e-01 | 0.0338 |
23301 | EHBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.24e-04 | -3.48e-01 | 0.0674 |
23301 | EHBP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.53e-02 | -4.37e-01 | 0.0588 |
23301 | EHBP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.53e-07 | -3.39e-01 | 0.294 |
23301 | EHBP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.01e-03 | -5.47e-01 | 0.2585 |
23301 | EHBP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.07e-07 | -4.18e-01 | 0.3005 |
23301 | EHBP1 | A001-C-207 | Human | Colorectum | FAP | 4.56e-03 | 1.35e-02 | 0.1278 |
23301 | EHBP1 | A015-C-203 | Human | Colorectum | FAP | 3.18e-30 | -4.13e-01 | -0.1294 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EHBP1 | deletion | Frame_Shift_Del | novel | c.2889delN | p.Ser964HisfsTer10 | p.S964Hfs*10 | Q8NDI1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
EHBP1 | SNV | Missense_Mutation | novel | c.29G>A | p.Arg10His | p.R10H | Q8NDI1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHBP1 | SNV | Missense_Mutation | rs750441921 | c.3572C>T | p.Ala1191Val | p.A1191V | Q8NDI1 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHBP1 | SNV | Missense_Mutation | novel | c.3286N>C | p.Glu1096Gln | p.E1096Q | Q8NDI1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A3HF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
EHBP1 | SNV | Missense_Mutation | c.2923G>C | p.Glu975Gln | p.E975Q | Q8NDI1 | protein_coding | deleterious(0.04) | benign(0.248) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
EHBP1 | SNV | Missense_Mutation | novel | c.1404N>G | p.Phe468Leu | p.F468L | Q8NDI1 | protein_coding | tolerated(0.21) | probably_damaging(0.996) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHBP1 | SNV | Missense_Mutation | c.1225N>T | p.Pro409Ser | p.P409S | Q8NDI1 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
EHBP1 | SNV | Missense_Mutation | rs368672515 | c.2435C>A | p.Ser812Tyr | p.S812Y | Q8NDI1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EHBP1 | SNV | Missense_Mutation | rs201434475 | c.2630G>A | p.Arg877Gln | p.R877Q | Q8NDI1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EHBP1 | SNV | Missense_Mutation | c.1418G>T | p.Arg473Ile | p.R473I | Q8NDI1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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