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Gene: DYNC2LI1 |
Gene summary for DYNC2LI1 |
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Gene information | Species | Human | Gene symbol | DYNC2LI1 | Gene ID | 51626 |
Gene name | dynein cytoplasmic 2 light intermediate chain 1 | |
Gene Alias | CGI-60 | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TCX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51626 | DYNC2LI1 | LZE3D | Human | Esophagus | HGIN | 5.92e-03 | 5.11e-01 | 0.0668 |
51626 | DYNC2LI1 | LZE4T | Human | Esophagus | ESCC | 1.42e-05 | 1.48e-01 | 0.0811 |
51626 | DYNC2LI1 | LZE7T | Human | Esophagus | ESCC | 1.01e-04 | 3.25e-01 | 0.0667 |
51626 | DYNC2LI1 | LZE24T | Human | Esophagus | ESCC | 3.89e-11 | 3.35e-01 | 0.0596 |
51626 | DYNC2LI1 | LZE21T | Human | Esophagus | ESCC | 1.89e-02 | 1.79e-01 | 0.0655 |
51626 | DYNC2LI1 | P1T-E | Human | Esophagus | ESCC | 4.07e-05 | 2.74e-01 | 0.0875 |
51626 | DYNC2LI1 | P2T-E | Human | Esophagus | ESCC | 1.19e-37 | 6.92e-01 | 0.1177 |
51626 | DYNC2LI1 | P4T-E | Human | Esophagus | ESCC | 2.19e-18 | 4.90e-01 | 0.1323 |
51626 | DYNC2LI1 | P5T-E | Human | Esophagus | ESCC | 1.56e-19 | 3.74e-01 | 0.1327 |
51626 | DYNC2LI1 | P8T-E | Human | Esophagus | ESCC | 7.64e-19 | 2.83e-01 | 0.0889 |
51626 | DYNC2LI1 | P9T-E | Human | Esophagus | ESCC | 3.52e-07 | 1.60e-01 | 0.1131 |
51626 | DYNC2LI1 | P10T-E | Human | Esophagus | ESCC | 2.74e-17 | 3.57e-01 | 0.116 |
51626 | DYNC2LI1 | P11T-E | Human | Esophagus | ESCC | 1.97e-11 | 3.41e-01 | 0.1426 |
51626 | DYNC2LI1 | P12T-E | Human | Esophagus | ESCC | 9.41e-13 | 2.93e-01 | 0.1122 |
51626 | DYNC2LI1 | P15T-E | Human | Esophagus | ESCC | 4.31e-10 | 1.94e-01 | 0.1149 |
51626 | DYNC2LI1 | P16T-E | Human | Esophagus | ESCC | 2.64e-25 | 5.00e-01 | 0.1153 |
51626 | DYNC2LI1 | P17T-E | Human | Esophagus | ESCC | 1.90e-03 | 1.95e-01 | 0.1278 |
51626 | DYNC2LI1 | P20T-E | Human | Esophagus | ESCC | 1.14e-08 | 2.28e-01 | 0.1124 |
51626 | DYNC2LI1 | P21T-E | Human | Esophagus | ESCC | 4.08e-16 | 3.07e-01 | 0.1617 |
51626 | DYNC2LI1 | P22T-E | Human | Esophagus | ESCC | 2.04e-33 | 6.16e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:006049118 | Esophagus | ESCC | regulation of cell projection assembly | 110/8552 | 188/18723 | 2.60e-04 | 1.58e-03 | 110 |
GO:012003218 | Esophagus | ESCC | regulation of plasma membrane bounded cell projection assembly | 108/8552 | 186/18723 | 4.37e-04 | 2.46e-03 | 108 |
GO:19021155 | Oral cavity | OSCC | regulation of organelle assembly | 109/7305 | 186/18723 | 4.54e-08 | 8.45e-07 | 109 |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:00315034 | Oral cavity | OSCC | protein-containing complex localization | 123/7305 | 220/18723 | 2.54e-07 | 4.00e-06 | 123 |
GO:00109706 | Oral cavity | OSCC | transport along microtubule | 88/7305 | 155/18723 | 5.35e-06 | 6.02e-05 | 88 |
GO:006049110 | Oral cavity | OSCC | regulation of cell projection assembly | 100/7305 | 188/18723 | 5.27e-05 | 4.38e-04 | 100 |
GO:012003216 | Oral cavity | OSCC | regulation of plasma membrane bounded cell projection assembly | 98/7305 | 186/18723 | 1.00e-04 | 7.54e-04 | 98 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0496223 | Esophagus | ESCC | Vasopressin-regulated water reabsorption | 33/4205 | 44/8465 | 5.27e-04 | 1.78e-03 | 9.13e-04 | 33 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0496233 | Esophagus | ESCC | Vasopressin-regulated water reabsorption | 33/4205 | 44/8465 | 5.27e-04 | 1.78e-03 | 9.13e-04 | 33 |
hsa0513230 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa049626 | Oral cavity | OSCC | Vasopressin-regulated water reabsorption | 29/3704 | 44/8465 | 2.47e-03 | 6.52e-03 | 3.32e-03 | 29 |
hsa05132114 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa0496213 | Oral cavity | OSCC | Vasopressin-regulated water reabsorption | 29/3704 | 44/8465 | 2.47e-03 | 6.52e-03 | 3.32e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DYNC2LI1 | SNV | Missense_Mutation | c.525T>G | p.Ile175Met | p.I175M | Q8TCX1 | protein_coding | tolerated(0.17) | benign(0.157) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DYNC2LI1 | SNV | Missense_Mutation | c.637T>C | p.Tyr213His | p.Y213H | Q8TCX1 | protein_coding | tolerated(0.21) | benign(0.035) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DYNC2LI1 | SNV | Missense_Mutation | novel | c.327N>G | p.Phe109Leu | p.F109L | Q8TCX1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DYNC2LI1 | SNV | Missense_Mutation | rs760977013 | c.244N>A | p.Ala82Thr | p.A82T | Q8TCX1 | protein_coding | tolerated(0.06) | possibly_damaging(0.562) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DYNC2LI1 | SNV | Missense_Mutation | novel | c.975N>T | p.Glu325Asp | p.E325D | Q8TCX1 | protein_coding | tolerated(0.36) | benign(0.017) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DYNC2LI1 | SNV | Missense_Mutation | novel | c.857C>T | p.Pro286Leu | p.P286L | Q8TCX1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYNC2LI1 | SNV | Missense_Mutation | c.1022N>A | p.Ser341Tyr | p.S341Y | Q8TCX1 | protein_coding | deleterious(0) | possibly_damaging(0.532) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DYNC2LI1 | SNV | Missense_Mutation | rs755856410 | c.694C>T | p.Arg232Cys | p.R232C | Q8TCX1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DYNC2LI1 | SNV | Missense_Mutation | novel | c.448N>A | p.Ala150Thr | p.A150T | Q8TCX1 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
DYNC2LI1 | SNV | Missense_Mutation | c.809C>A | p.Ser270Tyr | p.S270Y | Q8TCX1 | protein_coding | tolerated(0.48) | benign(0.404) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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