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Gene: DUSP18 |
Gene summary for DUSP18 |
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Gene information | Species | Human | Gene symbol | DUSP18 | Gene ID | 150290 |
Gene name | dual specificity phosphatase 18 | |
Gene Alias | DSP18 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R1L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150290 | DUSP18 | LZE7T | Human | Esophagus | ESCC | 1.10e-02 | 1.22e-01 | 0.0667 |
150290 | DUSP18 | LZE24T | Human | Esophagus | ESCC | 1.89e-09 | 3.19e-01 | 0.0596 |
150290 | DUSP18 | LZE21T | Human | Esophagus | ESCC | 1.43e-04 | 1.89e-01 | 0.0655 |
150290 | DUSP18 | P2T-E | Human | Esophagus | ESCC | 1.77e-15 | 1.55e-01 | 0.1177 |
150290 | DUSP18 | P4T-E | Human | Esophagus | ESCC | 7.38e-08 | 1.33e-01 | 0.1323 |
150290 | DUSP18 | P5T-E | Human | Esophagus | ESCC | 3.75e-03 | 6.63e-02 | 0.1327 |
150290 | DUSP18 | P8T-E | Human | Esophagus | ESCC | 3.93e-08 | 1.51e-01 | 0.0889 |
150290 | DUSP18 | P9T-E | Human | Esophagus | ESCC | 1.28e-07 | 1.11e-01 | 0.1131 |
150290 | DUSP18 | P10T-E | Human | Esophagus | ESCC | 1.88e-11 | 1.91e-01 | 0.116 |
150290 | DUSP18 | P11T-E | Human | Esophagus | ESCC | 1.93e-07 | 2.05e-01 | 0.1426 |
150290 | DUSP18 | P15T-E | Human | Esophagus | ESCC | 1.18e-10 | 1.75e-01 | 0.1149 |
150290 | DUSP18 | P16T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.06e-01 | 0.1153 |
150290 | DUSP18 | P17T-E | Human | Esophagus | ESCC | 7.86e-04 | 2.21e-01 | 0.1278 |
150290 | DUSP18 | P19T-E | Human | Esophagus | ESCC | 2.70e-10 | 4.17e-01 | 0.1662 |
150290 | DUSP18 | P21T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.15e-01 | 0.1617 |
150290 | DUSP18 | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.65e-01 | 0.1236 |
150290 | DUSP18 | P23T-E | Human | Esophagus | ESCC | 1.10e-08 | 1.97e-01 | 0.108 |
150290 | DUSP18 | P24T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.42e-01 | 0.1287 |
150290 | DUSP18 | P26T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.48e-01 | 0.1276 |
150290 | DUSP18 | P27T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.01e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00359703 | Esophagus | ESCC | peptidyl-threonine dephosphorylation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:00359701 | Liver | HCC | peptidyl-threonine dephosphorylation | 13/7958 | 16/18723 | 1.84e-03 | 9.42e-03 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP18 | SNV | Missense_Mutation | novel | c.7N>A | p.Ala3Thr | p.A3T | Q8NEJ0 | protein_coding | tolerated_low_confidence(0.71) | benign(0.001) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DUSP18 | SNV | Missense_Mutation | rs775345868 | c.436N>A | p.Gly146Ser | p.G146S | Q8NEJ0 | protein_coding | tolerated(0.05) | probably_damaging(0.921) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DUSP18 | SNV | Missense_Mutation | rs142285924 | c.547C>T | p.Arg183Cys | p.R183C | Q8NEJ0 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUSP18 | SNV | Missense_Mutation | novel | c.535N>C | p.Glu179Gln | p.E179Q | Q8NEJ0 | protein_coding | tolerated(0.17) | benign(0.109) | TCGA-F7-A50J-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
DUSP18 | SNV | Missense_Mutation | rs754173853 | c.412C>T | p.Arg138Trp | p.R138W | Q8NEJ0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
DUSP18 | SNV | Missense_Mutation | rs202138261 | c.329N>A | p.Arg110His | p.R110H | Q8NEJ0 | protein_coding | deleterious(0.05) | possibly_damaging(0.604) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
DUSP18 | SNV | Missense_Mutation | c.165N>T | p.Glu55Asp | p.E55D | Q8NEJ0 | protein_coding | tolerated(0.1) | benign(0.425) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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