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Gene: DNASE2 |
Gene summary for DNASE2 |
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Gene information | Species | Human | Gene symbol | DNASE2 | Gene ID | 1777 |
Gene name | deoxyribonuclease 2, lysosomal | |
Gene Alias | DNASE2A | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000737 | UniProtAcc | A0A024R7F4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1777 | DNASE2 | GSM4909281 | Human | Breast | IDC | 7.74e-04 | 2.30e-01 | 0.21 |
1777 | DNASE2 | GSM4909282 | Human | Breast | IDC | 1.61e-09 | 3.71e-01 | -0.0288 |
1777 | DNASE2 | GSM4909285 | Human | Breast | IDC | 1.06e-22 | 5.60e-01 | 0.21 |
1777 | DNASE2 | GSM4909311 | Human | Breast | IDC | 7.92e-06 | -2.43e-02 | 0.1534 |
1777 | DNASE2 | GSM4909319 | Human | Breast | IDC | 1.88e-07 | -1.26e-02 | 0.1563 |
1777 | DNASE2 | brca2 | Human | Breast | Precancer | 2.23e-02 | 1.61e-01 | -0.024 |
1777 | DNASE2 | P1 | Human | Breast | IDC | 8.56e-03 | 1.56e-01 | 0.1527 |
1777 | DNASE2 | DCIS2 | Human | Breast | DCIS | 3.00e-34 | 8.21e-02 | 0.0085 |
1777 | DNASE2 | LZE4T | Human | Esophagus | ESCC | 1.16e-10 | 3.75e-01 | 0.0811 |
1777 | DNASE2 | LZE7T | Human | Esophagus | ESCC | 3.77e-08 | 5.63e-01 | 0.0667 |
1777 | DNASE2 | LZE8T | Human | Esophagus | ESCC | 3.00e-06 | 1.63e-01 | 0.067 |
1777 | DNASE2 | LZE22T | Human | Esophagus | ESCC | 1.32e-07 | 3.67e-01 | 0.068 |
1777 | DNASE2 | LZE24T | Human | Esophagus | ESCC | 4.89e-26 | 7.66e-01 | 0.0596 |
1777 | DNASE2 | LZE21T | Human | Esophagus | ESCC | 2.47e-02 | 5.52e-01 | 0.0655 |
1777 | DNASE2 | LZE6T | Human | Esophagus | ESCC | 3.69e-04 | 4.31e-01 | 0.0845 |
1777 | DNASE2 | P1T-E | Human | Esophagus | ESCC | 7.86e-15 | 8.33e-01 | 0.0875 |
1777 | DNASE2 | P2T-E | Human | Esophagus | ESCC | 3.70e-28 | 5.02e-01 | 0.1177 |
1777 | DNASE2 | P4T-E | Human | Esophagus | ESCC | 3.98e-28 | 8.19e-01 | 0.1323 |
1777 | DNASE2 | P5T-E | Human | Esophagus | ESCC | 4.79e-14 | 4.02e-01 | 0.1327 |
1777 | DNASE2 | P8T-E | Human | Esophagus | ESCC | 1.18e-39 | 7.98e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00022629 | Breast | Precancer | myeloid cell homeostasis | 27/1080 | 157/18723 | 3.10e-07 | 1.49e-05 | 27 |
GO:00341019 | Breast | Precancer | erythrocyte homeostasis | 23/1080 | 129/18723 | 1.20e-06 | 4.60e-05 | 23 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00488729 | Breast | Precancer | homeostasis of number of cells | 32/1080 | 272/18723 | 1.03e-04 | 1.89e-03 | 32 |
GO:00302189 | Breast | Precancer | erythrocyte differentiation | 18/1080 | 120/18723 | 1.76e-04 | 2.87e-03 | 18 |
GO:00346558 | Breast | Precancer | nucleobase-containing compound catabolic process | 42/1080 | 407/18723 | 1.91e-04 | 3.06e-03 | 42 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00467007 | Breast | Precancer | heterocycle catabolic process | 44/1080 | 445/18723 | 3.49e-04 | 4.88e-03 | 44 |
GO:00442708 | Breast | Precancer | cellular nitrogen compound catabolic process | 44/1080 | 451/18723 | 4.64e-04 | 6.12e-03 | 44 |
GO:00194397 | Breast | Precancer | aromatic compound catabolic process | 44/1080 | 467/18723 | 9.55e-04 | 1.07e-02 | 44 |
GO:19013617 | Breast | Precancer | organic cyclic compound catabolic process | 45/1080 | 495/18723 | 1.73e-03 | 1.74e-02 | 45 |
GO:003410114 | Breast | IDC | erythrocyte homeostasis | 27/1434 | 129/18723 | 1.34e-06 | 5.75e-05 | 27 |
GO:000226214 | Breast | IDC | myeloid cell homeostasis | 30/1434 | 157/18723 | 2.64e-06 | 1.01e-04 | 30 |
GO:003009914 | Breast | IDC | myeloid cell differentiation | 54/1434 | 381/18723 | 8.07e-06 | 2.39e-04 | 54 |
GO:003021814 | Breast | IDC | erythrocyte differentiation | 22/1434 | 120/18723 | 1.04e-04 | 1.97e-03 | 22 |
GO:004887214 | Breast | IDC | homeostasis of number of cells | 36/1434 | 272/18723 | 9.10e-04 | 1.04e-02 | 36 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0462311 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa046232 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa046233 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNASE2 | SNV | Missense_Mutation | novel | c.244N>A | p.Leu82Met | p.L82M | O00115 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNASE2 | SNV | Missense_Mutation | novel | c.1006N>T | p.Ala336Ser | p.A336S | O00115 | protein_coding | tolerated(0.19) | benign(0.241) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DNASE2 | SNV | Missense_Mutation | novel | c.842T>C | p.Phe281Ser | p.F281S | O00115 | protein_coding | deleterious(0.04) | possibly_damaging(0.593) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
DNASE2 | SNV | Missense_Mutation | novel | c.911N>T | p.Gly304Val | p.G304V | O00115 | protein_coding | deleterious(0.03) | benign(0.309) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DNASE2 | SNV | Missense_Mutation | novel | c.797N>C | p.Asn266Thr | p.N266T | O00115 | protein_coding | deleterious(0) | benign(0.27) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNASE2 | SNV | Missense_Mutation | c.614N>G | p.His205Arg | p.H205R | O00115 | protein_coding | tolerated(0.12) | benign(0.012) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DNASE2 | SNV | Missense_Mutation | c.482C>A | p.Ser161Tyr | p.S161Y | O00115 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
DNASE2 | SNV | Missense_Mutation | novel | c.140N>T | p.Arg47Ile | p.R47I | O00115 | protein_coding | tolerated(0.1) | benign(0.296) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
DNASE2 | SNV | Missense_Mutation | rs544319961 | c.940C>T | p.Arg314Trp | p.R314W | O00115 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNASE2 | SNV | Missense_Mutation | c.544T>C | p.Tyr182His | p.Y182H | O00115 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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