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Gene: DIS3 |
Gene summary for DIS3 |
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Gene information | Species | Human | Gene symbol | DIS3 | Gene ID | 22894 |
Gene name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease | |
Gene Alias | 2810028N01Rik | |
Cytomap | 13q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q9Y2L1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22894 | DIS3 | LZE4T | Human | Esophagus | ESCC | 6.04e-05 | -3.73e-03 | 0.0811 |
22894 | DIS3 | LZE5T | Human | Esophagus | ESCC | 3.60e-06 | 6.38e-02 | 0.0514 |
22894 | DIS3 | LZE7T | Human | Esophagus | ESCC | 3.38e-05 | 3.05e-01 | 0.0667 |
22894 | DIS3 | LZE8T | Human | Esophagus | ESCC | 1.93e-05 | -1.07e-01 | 0.067 |
22894 | DIS3 | LZE20T | Human | Esophagus | ESCC | 2.64e-03 | -1.90e-02 | 0.0662 |
22894 | DIS3 | LZE21D1 | Human | Esophagus | HGIN | 1.74e-02 | -2.36e-02 | 0.0632 |
22894 | DIS3 | LZE22T | Human | Esophagus | ESCC | 2.62e-04 | 6.11e-03 | 0.068 |
22894 | DIS3 | LZE24T | Human | Esophagus | ESCC | 6.01e-11 | 2.40e-01 | 0.0596 |
22894 | DIS3 | LZE21T | Human | Esophagus | ESCC | 7.57e-03 | -9.83e-03 | 0.0655 |
22894 | DIS3 | LZE6T | Human | Esophagus | ESCC | 1.19e-02 | -7.71e-02 | 0.0845 |
22894 | DIS3 | P1T-E | Human | Esophagus | ESCC | 5.00e-12 | 2.94e-01 | 0.0875 |
22894 | DIS3 | P2T-E | Human | Esophagus | ESCC | 1.00e-20 | 2.22e-01 | 0.1177 |
22894 | DIS3 | P4T-E | Human | Esophagus | ESCC | 1.07e-07 | 3.80e-02 | 0.1323 |
22894 | DIS3 | P5T-E | Human | Esophagus | ESCC | 1.37e-07 | 1.48e-02 | 0.1327 |
22894 | DIS3 | P8T-E | Human | Esophagus | ESCC | 3.70e-15 | 4.22e-01 | 0.0889 |
22894 | DIS3 | P9T-E | Human | Esophagus | ESCC | 1.88e-09 | 2.14e-01 | 0.1131 |
22894 | DIS3 | P10T-E | Human | Esophagus | ESCC | 6.00e-23 | 3.00e-01 | 0.116 |
22894 | DIS3 | P11T-E | Human | Esophagus | ESCC | 6.89e-13 | 3.22e-01 | 0.1426 |
22894 | DIS3 | P12T-E | Human | Esophagus | ESCC | 8.51e-11 | 1.76e-01 | 0.1122 |
22894 | DIS3 | P15T-E | Human | Esophagus | ESCC | 1.39e-12 | 1.55e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:1903313 | Colorectum | AD | positive regulation of mRNA metabolic process | 44/3918 | 118/18723 | 3.20e-05 | 5.87e-04 | 44 |
GO:0000956 | Colorectum | AD | nuclear-transcribed mRNA catabolic process | 40/3918 | 112/18723 | 2.11e-04 | 2.79e-03 | 40 |
GO:0061014 | Colorectum | AD | positive regulation of mRNA catabolic process | 32/3918 | 87/18723 | 4.81e-04 | 5.27e-03 | 32 |
GO:0061157 | Colorectum | AD | mRNA destabilization | 30/3918 | 84/18723 | 1.24e-03 | 1.09e-02 | 30 |
GO:0050779 | Colorectum | AD | RNA destabilization | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301810 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa0301815 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DIS3 | SNV | Missense_Mutation | rs757537527 | c.1006N>A | p.Glu336Lys | p.E336K | Q9Y2L1 | protein_coding | tolerated(0.41) | benign(0) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | rs139907646 | c.1145G>A | p.Arg382Gln | p.R382Q | Q9Y2L1 | protein_coding | deleterious(0.01) | possibly_damaging(0.767) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | rs373230191 | c.802G>A | p.Asp268Asn | p.D268N | Q9Y2L1 | protein_coding | tolerated(0.12) | benign(0.357) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | novel | c.2545N>A | p.Glu849Lys | p.E849K | Q9Y2L1 | protein_coding | deleterious(0.03) | benign(0.33) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | novel | c.1939N>A | p.Asp647Asn | p.D647N | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DIS3 | SNV | Missense_Mutation | novel | c.2444N>C | p.Lys815Thr | p.K815T | Q9Y2L1 | protein_coding | tolerated(0.07) | benign(0.035) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DIS3 | SNV | Missense_Mutation | novel | c.1808N>C | p.Asn603Thr | p.N603T | Q9Y2L1 | protein_coding | tolerated(0.57) | benign(0.038) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DIS3 | SNV | Missense_Mutation | c.2066N>A | p.Arg689Gln | p.R689Q | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
DIS3 | SNV | Missense_Mutation | c.1540N>T | p.Arg514Trp | p.R514W | Q9Y2L1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DIS3 | SNV | Missense_Mutation | c.2374G>A | p.Ala792Thr | p.A792T | Q9Y2L1 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AG-3890-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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