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Gene: DDX51 |
Gene summary for DDX51 |
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Gene information | Species | Human | Gene symbol | DDX51 | Gene ID | 317781 |
Gene name | DEAD-box helicase 51 | |
Gene Alias | DDX51 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N8A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
317781 | DDX51 | HCC1_Meng | Human | Liver | HCC | 3.05e-23 | -9.10e-03 | 0.0246 |
317781 | DDX51 | HCC2_Meng | Human | Liver | HCC | 1.91e-04 | 1.28e-02 | 0.0107 |
317781 | DDX51 | HCC1 | Human | Liver | HCC | 7.30e-25 | 3.56e+00 | 0.5336 |
317781 | DDX51 | HCC2 | Human | Liver | HCC | 3.88e-34 | 3.15e+00 | 0.5341 |
317781 | DDX51 | HCC5 | Human | Liver | HCC | 4.95e-34 | 2.04e+00 | 0.4932 |
317781 | DDX51 | S027 | Human | Liver | HCC | 4.75e-05 | 5.04e-01 | 0.2446 |
317781 | DDX51 | S028 | Human | Liver | HCC | 2.21e-06 | 3.78e-01 | 0.2503 |
317781 | DDX51 | S029 | Human | Liver | HCC | 1.18e-05 | 3.55e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX51 | SNV | Missense_Mutation | rs201806124 | c.1027G>A | p.Val343Met | p.V343M | Q8N8A6 | protein_coding | deleterious(0.03) | possibly_damaging(0.577) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
DDX51 | SNV | Missense_Mutation | novel | c.1903T>A | p.Ser635Thr | p.S635T | Q8N8A6 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | novel | c.1762A>G | p.Thr588Ala | p.T588A | Q8N8A6 | protein_coding | deleterious(0.02) | possibly_damaging(0.643) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | novel | c.817G>A | p.Ala273Thr | p.A273T | Q8N8A6 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | rs544795955 | c.1856N>A | p.Arg619Gln | p.R619Q | Q8N8A6 | protein_coding | tolerated(0.72) | benign(0.011) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DDX51 | SNV | Missense_Mutation | rs370529011 | c.1741N>A | p.Asp581Asn | p.D581N | Q8N8A6 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DDX51 | SNV | Missense_Mutation | rs773766700 | c.1063G>A | p.Asp355Asn | p.D355N | Q8N8A6 | protein_coding | tolerated(0.73) | benign(0.006) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | novel | c.1736N>G | p.Asn579Ser | p.N579S | Q8N8A6 | protein_coding | tolerated(0.21) | probably_damaging(0.951) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | rs753901298 | c.1612C>T | p.Arg538Cys | p.R538C | Q8N8A6 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX51 | SNV | Missense_Mutation | rs868798392 | c.650G>A | p.Gly217Asp | p.G217D | Q8N8A6 | protein_coding | deleterious(0.01) | possibly_damaging(0.677) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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