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Gene: DDHD1 |
Gene summary for DDHD1 |
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Gene information | Species | Human | Gene symbol | DDHD1 | Gene ID | 80821 |
Gene name | DDHD domain containing 1 | |
Gene Alias | PA-PLA1 | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q8NEL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80821 | DDHD1 | LZE4T | Human | Esophagus | ESCC | 7.18e-08 | 3.52e-01 | 0.0811 |
80821 | DDHD1 | LZE24T | Human | Esophagus | ESCC | 2.64e-05 | 2.11e-01 | 0.0596 |
80821 | DDHD1 | P2T-E | Human | Esophagus | ESCC | 1.69e-15 | 3.50e-01 | 0.1177 |
80821 | DDHD1 | P4T-E | Human | Esophagus | ESCC | 1.37e-10 | 2.07e-01 | 0.1323 |
80821 | DDHD1 | P8T-E | Human | Esophagus | ESCC | 1.37e-09 | 1.72e-01 | 0.0889 |
80821 | DDHD1 | P9T-E | Human | Esophagus | ESCC | 7.25e-10 | 1.99e-01 | 0.1131 |
80821 | DDHD1 | P10T-E | Human | Esophagus | ESCC | 4.26e-14 | 1.96e-01 | 0.116 |
80821 | DDHD1 | P11T-E | Human | Esophagus | ESCC | 3.09e-04 | 3.34e-01 | 0.1426 |
80821 | DDHD1 | P12T-E | Human | Esophagus | ESCC | 1.38e-25 | 3.68e-01 | 0.1122 |
80821 | DDHD1 | P15T-E | Human | Esophagus | ESCC | 1.54e-15 | 3.53e-01 | 0.1149 |
80821 | DDHD1 | P16T-E | Human | Esophagus | ESCC | 8.40e-10 | 1.86e-01 | 0.1153 |
80821 | DDHD1 | P20T-E | Human | Esophagus | ESCC | 1.07e-07 | 2.16e-01 | 0.1124 |
80821 | DDHD1 | P21T-E | Human | Esophagus | ESCC | 1.69e-07 | 1.23e-01 | 0.1617 |
80821 | DDHD1 | P22T-E | Human | Esophagus | ESCC | 8.79e-14 | 1.89e-01 | 0.1236 |
80821 | DDHD1 | P26T-E | Human | Esophagus | ESCC | 3.61e-17 | 3.28e-01 | 0.1276 |
80821 | DDHD1 | P27T-E | Human | Esophagus | ESCC | 5.17e-20 | 3.55e-01 | 0.1055 |
80821 | DDHD1 | P28T-E | Human | Esophagus | ESCC | 6.25e-24 | 5.48e-01 | 0.1149 |
80821 | DDHD1 | P30T-E | Human | Esophagus | ESCC | 5.73e-08 | 4.44e-01 | 0.137 |
80821 | DDHD1 | P31T-E | Human | Esophagus | ESCC | 1.43e-07 | 1.18e-01 | 0.1251 |
80821 | DDHD1 | P32T-E | Human | Esophagus | ESCC | 5.44e-03 | 1.33e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:0010821110 | Esophagus | ESCC | regulation of mitochondrion organization | 107/8552 | 144/18723 | 2.31e-12 | 9.41e-11 | 107 |
GO:001082215 | Esophagus | ESCC | positive regulation of mitochondrion organization | 58/8552 | 74/18723 | 8.55e-09 | 1.73e-07 | 58 |
GO:00901411 | Esophagus | ESCC | positive regulation of mitochondrial fission | 16/8552 | 21/18723 | 4.47e-03 | 1.76e-02 | 16 |
GO:00002662 | Esophagus | ESCC | mitochondrial fission | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:001082112 | Liver | HCC | regulation of mitochondrion organization | 96/7958 | 144/18723 | 3.82e-09 | 1.02e-07 | 96 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
GO:001082211 | Liver | HCC | positive regulation of mitochondrion organization | 48/7958 | 74/18723 | 8.50e-05 | 7.46e-04 | 48 |
GO:0000266 | Liver | HCC | mitochondrial fission | 28/7958 | 42/18723 | 1.35e-03 | 7.26e-03 | 28 |
GO:0090140 | Liver | HCC | regulation of mitochondrial fission | 21/7958 | 32/18723 | 7.02e-03 | 2.80e-02 | 21 |
GO:001082124 | Thyroid | PTC | regulation of mitochondrion organization | 78/5968 | 144/18723 | 2.38e-08 | 5.43e-07 | 78 |
GO:001082210 | Thyroid | PTC | positive regulation of mitochondrion organization | 40/5968 | 74/18723 | 6.30e-05 | 5.53e-04 | 40 |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00901402 | Thyroid | PTC | regulation of mitochondrial fission | 17/5968 | 32/18723 | 1.02e-02 | 4.11e-02 | 17 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:0010821112 | Thyroid | ATC | regulation of mitochondrion organization | 82/6293 | 144/18723 | 7.15e-09 | 1.54e-07 | 82 |
GO:001082216 | Thyroid | ATC | positive regulation of mitochondrion organization | 43/6293 | 74/18723 | 1.30e-05 | 1.25e-04 | 43 |
GO:00901413 | Thyroid | ATC | positive regulation of mitochondrial fission | 14/6293 | 21/18723 | 1.99e-03 | 9.54e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDHD1 | SNV | Missense_Mutation | c.2209N>A | p.Glu737Lys | p.E737K | Q8NEL9 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
DDHD1 | SNV | Missense_Mutation | c.1919G>A | p.Gly640Glu | p.G640E | Q8NEL9 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
DDHD1 | SNV | Missense_Mutation | c.1258G>C | p.Asp420His | p.D420H | Q8NEL9 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DDHD1 | SNV | Missense_Mutation | novel | c.1339G>A | p.Ala447Thr | p.A447T | Q8NEL9 | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDHD1 | SNV | Missense_Mutation | novel | c.8A>G | p.Tyr3Cys | p.Y3C | Q8NEL9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.993) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DDHD1 | SNV | Missense_Mutation | c.1660N>T | p.Arg554Trp | p.R554W | Q8NEL9 | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DDHD1 | SNV | Missense_Mutation | c.1039A>T | p.Asn347Tyr | p.N347Y | Q8NEL9 | protein_coding | tolerated(0.76) | benign(0.035) | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DDHD1 | SNV | Missense_Mutation | rs780032756 | c.1765N>T | p.Arg589Trp | p.R589W | Q8NEL9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DDHD1 | SNV | Missense_Mutation | novel | c.2641T>G | p.Leu881Val | p.L881V | Q8NEL9 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDHD1 | SNV | Missense_Mutation | novel | c.2456C>T | p.Ser819Leu | p.S819L | Q8NEL9 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.992) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80821 | DDHD1 | PHOSPHOLIPASE | warfarin | WARFARIN | 27488176 |
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