![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DCUN1D5 |
Gene summary for DCUN1D5 |
![]() |
Gene information | Species | Human | Gene symbol | DCUN1D5 | Gene ID | 84259 |
Gene name | defective in cullin neddylation 1 domain containing 5 | |
Gene Alias | DCNL5 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | B4DP84 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84259 | DCUN1D5 | LZE4T | Human | Esophagus | ESCC | 9.22e-15 | 6.87e-01 | 0.0811 |
84259 | DCUN1D5 | LZE7T | Human | Esophagus | ESCC | 1.33e-02 | 6.10e-01 | 0.0667 |
84259 | DCUN1D5 | LZE8T | Human | Esophagus | ESCC | 1.97e-09 | 6.20e-01 | 0.067 |
84259 | DCUN1D5 | LZE20T | Human | Esophagus | ESCC | 4.20e-03 | 2.60e-01 | 0.0662 |
84259 | DCUN1D5 | LZE21D1 | Human | Esophagus | HGIN | 3.26e-02 | 8.45e-02 | 0.0632 |
84259 | DCUN1D5 | LZE22D1 | Human | Esophagus | HGIN | 1.18e-12 | 1.69e+00 | 0.0595 |
84259 | DCUN1D5 | LZE22T | Human | Esophagus | ESCC | 5.35e-27 | 3.63e+00 | 0.068 |
84259 | DCUN1D5 | LZE24T | Human | Esophagus | ESCC | 4.61e-26 | 1.00e+00 | 0.0596 |
84259 | DCUN1D5 | LZE22D3 | Human | Esophagus | HGIN | 1.19e-04 | 2.23e+00 | 0.0653 |
84259 | DCUN1D5 | LZE21T | Human | Esophagus | ESCC | 3.05e-04 | 6.44e-02 | 0.0655 |
84259 | DCUN1D5 | LZE6T | Human | Esophagus | ESCC | 5.69e-08 | 4.15e-01 | 0.0845 |
84259 | DCUN1D5 | P1T-E | Human | Esophagus | ESCC | 4.80e-03 | 2.19e-01 | 0.0875 |
84259 | DCUN1D5 | P2T-E | Human | Esophagus | ESCC | 1.09e-21 | 4.09e-01 | 0.1177 |
84259 | DCUN1D5 | P4T-E | Human | Esophagus | ESCC | 1.52e-47 | 1.73e+00 | 0.1323 |
84259 | DCUN1D5 | P5T-E | Human | Esophagus | ESCC | 6.09e-69 | 1.65e+00 | 0.1327 |
84259 | DCUN1D5 | P8T-E | Human | Esophagus | ESCC | 1.52e-75 | 1.58e+00 | 0.0889 |
84259 | DCUN1D5 | P9T-E | Human | Esophagus | ESCC | 1.31e-20 | 6.63e-01 | 0.1131 |
84259 | DCUN1D5 | P10T-E | Human | Esophagus | ESCC | 5.21e-38 | 6.63e-01 | 0.116 |
84259 | DCUN1D5 | P11T-E | Human | Esophagus | ESCC | 2.17e-17 | 1.12e+00 | 0.1426 |
84259 | DCUN1D5 | P12T-E | Human | Esophagus | ESCC | 1.90e-47 | 8.81e-01 | 0.1122 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:003139627 | Esophagus | HGIN | regulation of protein ubiquitination | 64/2587 | 210/18723 | 3.02e-10 | 2.71e-08 | 64 |
GO:19033228 | Esophagus | HGIN | positive regulation of protein modification by small protein conjugation or removal | 35/2587 | 138/18723 | 2.11e-04 | 3.88e-03 | 35 |
GO:001604919 | Esophagus | HGIN | cell growth | 93/2587 | 482/18723 | 4.49e-04 | 6.62e-03 | 93 |
GO:00451166 | Esophagus | HGIN | protein neddylation | 8/2587 | 18/18723 | 1.58e-03 | 1.79e-02 | 8 |
GO:00313987 | Esophagus | HGIN | positive regulation of protein ubiquitination | 28/2587 | 119/18723 | 2.89e-03 | 2.81e-02 | 28 |
GO:000155818 | Esophagus | HGIN | regulation of cell growth | 76/2587 | 414/18723 | 5.40e-03 | 4.42e-02 | 76 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:005143819 | Esophagus | ESCC | regulation of ubiquitin-protein transferase activity | 38/8552 | 53/18723 | 1.10e-04 | 7.69e-04 | 38 |
GO:004511614 | Esophagus | ESCC | protein neddylation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00514433 | Esophagus | ESCC | positive regulation of ubiquitin-protein transferase activity | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:003139612 | Liver | Cirrhotic | regulation of protein ubiquitination | 89/4634 | 210/18723 | 1.40e-08 | 5.30e-07 | 89 |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:19033222 | Liver | Cirrhotic | positive regulation of protein modification by small protein conjugation or removal | 52/4634 | 138/18723 | 4.91e-04 | 3.94e-03 | 52 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCUN1D5 | SNV | Missense_Mutation | novel | c.23N>G | p.Lys8Arg | p.K8R | Q9BTE7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DCUN1D5 | SNV | Missense_Mutation | novel | c.616A>T | p.Thr206Ser | p.T206S | Q9BTE7 | protein_coding | tolerated(0.18) | benign(0.17) | TCGA-DD-AAC9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCUN1D5 | SNV | Missense_Mutation | novel | c.533N>T | p.Ser178Leu | p.S178L | Q9BTE7 | protein_coding | tolerated(0.13) | benign(0.315) | TCGA-49-AAQV-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DCUN1D5 | insertion | Nonsense_Mutation | novel | c.691_692insTTTGTTGAGTGGC | p.Gln231LeufsTer3 | p.Q231Lfs*3 | Q9BTE7 | protein_coding | TCGA-66-2755-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
DCUN1D5 | SNV | Missense_Mutation | novel | c.194N>G | p.Val65Gly | p.V65G | Q9BTE7 | protein_coding | deleterious(0) | benign(0.303) | TCGA-P3-A5QA-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
DCUN1D5 | insertion | Frame_Shift_Ins | novel | c.303dupT | p.Thr102TyrfsTer15 | p.T102Yfs*15 | Q9BTE7 | protein_coding | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | ||
DCUN1D5 | deletion | Frame_Shift_Del | novel | c.303delN | p.Phe101LeufsTer7 | p.F101Lfs*7 | Q9BTE7 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |