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Gene: DCLRE1C |
Gene summary for DCLRE1C |
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Gene information | Species | Human | Gene symbol | DCLRE1C | Gene ID | 64421 |
Gene name | DNA cross-link repair 1C | |
Gene Alias | A-SCID | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q96SD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64421 | DCLRE1C | LZE22T | Human | Esophagus | ESCC | 5.58e-03 | 2.23e-01 | 0.068 |
64421 | DCLRE1C | LZE24T | Human | Esophagus | ESCC | 7.12e-11 | 4.51e-01 | 0.0596 |
64421 | DCLRE1C | LZE6T | Human | Esophagus | ESCC | 4.33e-02 | 1.28e-01 | 0.0845 |
64421 | DCLRE1C | P1T-E | Human | Esophagus | ESCC | 4.28e-06 | 6.42e-01 | 0.0875 |
64421 | DCLRE1C | P2T-E | Human | Esophagus | ESCC | 2.11e-11 | 2.19e-01 | 0.1177 |
64421 | DCLRE1C | P4T-E | Human | Esophagus | ESCC | 5.34e-07 | 1.48e-01 | 0.1323 |
64421 | DCLRE1C | P5T-E | Human | Esophagus | ESCC | 6.48e-04 | 9.53e-02 | 0.1327 |
64421 | DCLRE1C | P8T-E | Human | Esophagus | ESCC | 2.99e-09 | 1.60e-01 | 0.0889 |
64421 | DCLRE1C | P9T-E | Human | Esophagus | ESCC | 1.70e-02 | 5.19e-02 | 0.1131 |
64421 | DCLRE1C | P10T-E | Human | Esophagus | ESCC | 1.54e-11 | 1.68e-01 | 0.116 |
64421 | DCLRE1C | P12T-E | Human | Esophagus | ESCC | 2.53e-14 | 1.87e-01 | 0.1122 |
64421 | DCLRE1C | P15T-E | Human | Esophagus | ESCC | 1.31e-07 | 1.18e-01 | 0.1149 |
64421 | DCLRE1C | P16T-E | Human | Esophagus | ESCC | 6.04e-09 | 1.59e-01 | 0.1153 |
64421 | DCLRE1C | P20T-E | Human | Esophagus | ESCC | 6.06e-15 | 1.98e-01 | 0.1124 |
64421 | DCLRE1C | P21T-E | Human | Esophagus | ESCC | 4.68e-13 | 3.09e-01 | 0.1617 |
64421 | DCLRE1C | P23T-E | Human | Esophagus | ESCC | 1.56e-06 | 3.02e-01 | 0.108 |
64421 | DCLRE1C | P24T-E | Human | Esophagus | ESCC | 5.65e-10 | 1.92e-01 | 0.1287 |
64421 | DCLRE1C | P26T-E | Human | Esophagus | ESCC | 1.12e-06 | 1.66e-01 | 0.1276 |
64421 | DCLRE1C | P27T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.45e-01 | 0.1055 |
64421 | DCLRE1C | P28T-E | Human | Esophagus | ESCC | 7.63e-04 | 5.58e-02 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00162332 | Esophagus | ESCC | telomere capping | 28/8552 | 39/18723 | 8.57e-04 | 4.40e-03 | 28 |
GO:00025622 | Esophagus | ESCC | somatic diversification of immune receptors via germline recombination within a single locus | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:0006303 | Esophagus | ESCC | double-strand break repair via nonhomologous end joining | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00164442 | Esophagus | ESCC | somatic cell DNA recombination | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00022003 | Esophagus | ESCC | somatic diversification of immune receptors | 49/8552 | 77/18723 | 1.12e-03 | 5.60e-03 | 49 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:001021221 | Liver | HCC | response to ionizing radiation | 89/7958 | 148/18723 | 1.10e-05 | 1.26e-04 | 89 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00322001 | Liver | HCC | telomere organization | 86/7958 | 159/18723 | 2.06e-03 | 1.04e-02 | 86 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCLRE1C | SNV | Missense_Mutation | c.1133N>T | p.Ala378Val | p.A378V | Q96SD1 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DCLRE1C | SNV | Missense_Mutation | c.71N>C | p.Leu24Pro | p.L24P | Q96SD1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DCLRE1C | SNV | Missense_Mutation | novel | c.538G>A | p.Glu180Lys | p.E180K | Q96SD1 | protein_coding | tolerated(0.09) | benign(0.069) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCLRE1C | SNV | Missense_Mutation | c.767N>A | p.Cys256Tyr | p.C256Y | Q96SD1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DCLRE1C | SNV | Missense_Mutation | novel | c.2051N>C | p.Lys684Thr | p.K684T | Q96SD1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.054) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DCLRE1C | SNV | Missense_Mutation | rs541855040 | c.1057N>A | p.Glu353Lys | p.E353K | Q96SD1 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DCLRE1C | SNV | Missense_Mutation | rs768393244 | c.1009N>A | p.Ala337Thr | p.A337T | Q96SD1 | protein_coding | deleterious(0.01) | benign(0.36) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
DCLRE1C | SNV | Missense_Mutation | c.4N>C | p.Ser2Arg | p.S2R | Q96SD1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DCLRE1C | SNV | Missense_Mutation | rs541855040 | c.1057N>A | p.Glu353Lys | p.E353K | Q96SD1 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
DCLRE1C | deletion | Frame_Shift_Del | c.2053delN | p.Arg685GlufsTer6 | p.R685Efs*6 | Q96SD1 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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