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Gene: DAZAP1 |
Gene summary for DAZAP1 |
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Gene information | Species | Human | Gene symbol | DAZAP1 | Gene ID | 26528 |
Gene name | DAZ associated protein 1 | |
Gene Alias | DAZAP1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A0S2Z569 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26528 | DAZAP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.83e-02 | 6.47e-02 | 0.0155 |
26528 | DAZAP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.06e-06 | 3.00e-01 | -0.1954 |
26528 | DAZAP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.60e-05 | 4.79e-01 | -0.059 |
26528 | DAZAP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.65e-02 | 3.91e-01 | -0.0179 |
26528 | DAZAP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.75e-05 | 4.30e-01 | 0.294 |
26528 | DAZAP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.75e-12 | 6.77e-01 | 0.3859 |
26528 | DAZAP1 | A015-C-203 | Human | Colorectum | FAP | 6.94e-06 | 2.58e-02 | -0.1294 |
26528 | DAZAP1 | A002-C-205 | Human | Colorectum | FAP | 8.56e-04 | -2.23e-01 | -0.1236 |
26528 | DAZAP1 | A015-C-106 | Human | Colorectum | FAP | 2.60e-02 | 2.11e-02 | -0.0511 |
26528 | DAZAP1 | A015-C-104 | Human | Colorectum | FAP | 9.06e-07 | -2.73e-02 | -0.1899 |
26528 | DAZAP1 | A002-C-016 | Human | Colorectum | FAP | 2.32e-04 | -8.14e-02 | 0.0521 |
26528 | DAZAP1 | A002-C-116 | Human | Colorectum | FAP | 1.34e-09 | -2.11e-01 | -0.0452 |
26528 | DAZAP1 | F034 | Human | Colorectum | FAP | 1.93e-04 | -1.03e-01 | -0.0665 |
26528 | DAZAP1 | LZE2T | Human | Esophagus | ESCC | 3.40e-05 | 4.46e-01 | 0.082 |
26528 | DAZAP1 | LZE4T | Human | Esophagus | ESCC | 4.47e-04 | -9.87e-03 | 0.0811 |
26528 | DAZAP1 | LZE5T | Human | Esophagus | ESCC | 1.79e-03 | 1.46e-01 | 0.0514 |
26528 | DAZAP1 | LZE7T | Human | Esophagus | ESCC | 1.70e-06 | 3.44e-01 | 0.0667 |
26528 | DAZAP1 | LZE20T | Human | Esophagus | ESCC | 1.92e-08 | 6.76e-02 | 0.0662 |
26528 | DAZAP1 | LZE22D1 | Human | Esophagus | HGIN | 1.15e-04 | 5.74e-02 | 0.0595 |
26528 | DAZAP1 | LZE22T | Human | Esophagus | ESCC | 5.10e-07 | 2.79e-01 | 0.068 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0048024 | Colorectum | AD | regulation of mRNA splicing, via spliceosome | 50/3918 | 101/18723 | 1.62e-10 | 1.56e-08 | 50 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:1903313 | Colorectum | AD | positive regulation of mRNA metabolic process | 44/3918 | 118/18723 | 3.20e-05 | 5.87e-04 | 44 |
GO:0001890 | Colorectum | AD | placenta development | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0033120 | Colorectum | AD | positive regulation of RNA splicing | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
GO:0048026 | Colorectum | AD | positive regulation of mRNA splicing, via spliceosome | 12/3918 | 22/18723 | 5.38e-04 | 5.74e-03 | 12 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:19033112 | Colorectum | MSS | regulation of mRNA metabolic process | 115/3467 | 288/18723 | 1.23e-17 | 6.41e-15 | 115 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00434842 | Colorectum | MSS | regulation of RNA splicing | 66/3467 | 148/18723 | 2.44e-13 | 5.25e-11 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030152 | Colorectum | FAP | mRNA surveillance pathway | 26/1404 | 97/8465 | 7.11e-03 | 2.64e-02 | 1.60e-02 | 26 |
hsa030153 | Colorectum | FAP | mRNA surveillance pathway | 26/1404 | 97/8465 | 7.11e-03 | 2.64e-02 | 1.60e-02 | 26 |
hsa030159 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa0301514 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa030154 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa0301511 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0301531 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa030158 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301523 | Oral cavity | LP | mRNA surveillance pathway | 50/2418 | 97/8465 | 1.39e-06 | 1.50e-05 | 9.66e-06 | 50 |
hsa0301533 | Oral cavity | LP | mRNA surveillance pathway | 50/2418 | 97/8465 | 1.39e-06 | 1.50e-05 | 9.66e-06 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DAZAP1 | SNV | Missense_Mutation | c.1195N>A | p.Val399Met | p.V399M | Q96EP5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.971) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DAZAP1 | SNV | Missense_Mutation | c.974C>T | p.Pro325Leu | p.P325L | Q96EP5 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DAZAP1 | deletion | Frame_Shift_Del | c.764delN | p.Pro257ArgfsTer78 | p.P257Rfs*78 | Q96EP5 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
DAZAP1 | deletion | Frame_Shift_Del | c.770delC | p.Pro257ArgfsTer78 | p.P257Rfs*78 | Q96EP5 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
DAZAP1 | deletion | Frame_Shift_Del | c.770delC | p.Pro257ArgfsTer78 | p.P257Rfs*78 | Q96EP5 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
DAZAP1 | insertion | Frame_Shift_Ins | novel | c.763_764insC | p.Pro258AlafsTer169 | p.P258Afs*169 | Q96EP5 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DAZAP1 | insertion | Frame_Shift_Ins | novel | c.770dupC | p.Pro258AlafsTer169 | p.P258Afs*169 | Q96EP5 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DAZAP1 | insertion | Frame_Shift_Ins | novel | c.763_764insC | p.Pro258AlafsTer169 | p.P258Afs*169 | Q96EP5 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
DAZAP1 | deletion | Frame_Shift_Del | c.764delN | p.Pro257ArgfsTer78 | p.P257Rfs*78 | Q96EP5 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
DAZAP1 | deletion | Frame_Shift_Del | c.764delN | p.Pro257ArgfsTer78 | p.P257Rfs*78 | Q96EP5 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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