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Gene: CYP4V2 |
Gene summary for CYP4V2 |
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Gene information | Species | Human | Gene symbol | CYP4V2 | Gene ID | 285440 |
Gene name | cytochrome P450 family 4 subfamily V member 2 | |
Gene Alias | BCD | |
Cytomap | 4q35.1-q35.2 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q6ZWL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285440 | CYP4V2 | S43 | Human | Liver | Cirrhotic | 1.22e-03 | 1.07e-01 | -0.0187 |
285440 | CYP4V2 | HCC1_Meng | Human | Liver | HCC | 5.60e-18 | -8.18e-02 | 0.0246 |
285440 | CYP4V2 | HCC2_Meng | Human | Liver | HCC | 3.57e-15 | 5.44e-02 | 0.0107 |
285440 | CYP4V2 | HCC1 | Human | Liver | HCC | 1.68e-05 | 3.11e+00 | 0.5336 |
285440 | CYP4V2 | S027 | Human | Liver | HCC | 1.40e-02 | 5.22e-01 | 0.2446 |
285440 | CYP4V2 | S028 | Human | Liver | HCC | 3.36e-17 | 6.98e-01 | 0.2503 |
285440 | CYP4V2 | S029 | Human | Liver | HCC | 2.80e-12 | 7.03e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:00161251 | Liver | Cirrhotic | sterol metabolic process | 75/4634 | 152/18723 | 4.54e-11 | 2.61e-09 | 75 |
GO:001939512 | Liver | Cirrhotic | fatty acid oxidation | 53/4634 | 103/18723 | 4.73e-09 | 1.88e-07 | 53 |
GO:003444011 | Liver | Cirrhotic | lipid oxidation | 53/4634 | 108/18723 | 3.85e-08 | 1.27e-06 | 53 |
GO:00067202 | Liver | Cirrhotic | isoprenoid metabolic process | 46/4634 | 116/18723 | 2.71e-04 | 2.41e-03 | 46 |
GO:003025811 | Liver | Cirrhotic | lipid modification | 75/4634 | 212/18723 | 3.33e-04 | 2.87e-03 | 75 |
GO:00067212 | Liver | Cirrhotic | terpenoid metabolic process | 38/4634 | 97/18723 | 1.16e-03 | 7.89e-03 | 38 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:00161252 | Liver | HCC | sterol metabolic process | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:001939522 | Liver | HCC | fatty acid oxidation | 72/7958 | 103/18723 | 1.63e-08 | 3.92e-07 | 72 |
GO:003444021 | Liver | HCC | lipid oxidation | 73/7958 | 108/18723 | 1.17e-07 | 2.25e-06 | 73 |
GO:003025821 | Liver | HCC | lipid modification | 123/7958 | 212/18723 | 3.50e-06 | 4.58e-05 | 123 |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYP4V2 | SNV | Missense_Mutation | novel | c.1519C>A | p.Leu507Ile | p.L507I | Q6ZWL3 | protein_coding | deleterious(0.02) | possibly_damaging(0.838) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYP4V2 | deletion | Frame_Shift_Del | c.565delN | p.Tyr191ThrfsTer7 | p.Y191Tfs*7 | Q6ZWL3 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
CYP4V2 | SNV | Missense_Mutation | novel | c.355G>A | p.Asp119Asn | p.D119N | Q6ZWL3 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CYP4V2 | SNV | Missense_Mutation | rs766647591 | c.1084G>A | p.Val362Met | p.V362M | Q6ZWL3 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CYP4V2 | SNV | Missense_Mutation | novel | c.709N>T | p.Pro237Ser | p.P237S | Q6ZWL3 | protein_coding | deleterious(0) | possibly_damaging(0.791) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP4V2 | SNV | Missense_Mutation | rs762474840 | c.886C>T | p.Arg296Cys | p.R296C | Q6ZWL3 | protein_coding | deleterious(0.03) | benign(0.415) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CYP4V2 | SNV | Missense_Mutation | c.971A>G | p.Asp324Gly | p.D324G | Q6ZWL3 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYP4V2 | SNV | Missense_Mutation | rs767139838 | c.1285N>T | p.Asp429Tyr | p.D429Y | Q6ZWL3 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CYP4V2 | SNV | Missense_Mutation | rs142136741 | c.832N>A | p.Ala278Thr | p.A278T | Q6ZWL3 | protein_coding | tolerated(0.57) | benign(0.009) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP4V2 | SNV | Missense_Mutation | novel | c.599T>C | p.Ile200Thr | p.I200T | Q6ZWL3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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