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Gene: CYP2S1 |
Gene summary for CYP2S1 |
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Gene information | Species | Human | Gene symbol | CYP2S1 | Gene ID | 29785 |
Gene name | cytochrome P450 family 2 subfamily S member 1 | |
Gene Alias | CYPIIS1 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q96SQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29785 | CYP2S1 | LZE4T | Human | Esophagus | ESCC | 2.05e-18 | 7.52e-01 | 0.0811 |
29785 | CYP2S1 | LZE7T | Human | Esophagus | ESCC | 2.53e-10 | 5.75e-01 | 0.0667 |
29785 | CYP2S1 | LZE8T | Human | Esophagus | ESCC | 8.11e-14 | 5.42e-01 | 0.067 |
29785 | CYP2S1 | LZE22D1 | Human | Esophagus | HGIN | 2.35e-02 | 3.09e-01 | 0.0595 |
29785 | CYP2S1 | LZE22T | Human | Esophagus | ESCC | 6.66e-10 | 4.30e-01 | 0.068 |
29785 | CYP2S1 | LZE24T | Human | Esophagus | ESCC | 3.41e-19 | 7.26e-01 | 0.0596 |
29785 | CYP2S1 | LZE22D3 | Human | Esophagus | HGIN | 3.43e-02 | 8.08e-01 | 0.0653 |
29785 | CYP2S1 | LZE21T | Human | Esophagus | ESCC | 1.86e-09 | 8.15e-01 | 0.0655 |
29785 | CYP2S1 | P1T-E | Human | Esophagus | ESCC | 4.94e-07 | 5.43e-01 | 0.0875 |
29785 | CYP2S1 | P2T-E | Human | Esophagus | ESCC | 2.29e-10 | 9.34e-02 | 0.1177 |
29785 | CYP2S1 | P4T-E | Human | Esophagus | ESCC | 1.86e-34 | 9.19e-01 | 0.1323 |
29785 | CYP2S1 | P5T-E | Human | Esophagus | ESCC | 1.24e-57 | 1.29e+00 | 0.1327 |
29785 | CYP2S1 | P8T-E | Human | Esophagus | ESCC | 5.15e-44 | 1.07e+00 | 0.0889 |
29785 | CYP2S1 | P9T-E | Human | Esophagus | ESCC | 1.07e-21 | 6.18e-01 | 0.1131 |
29785 | CYP2S1 | P10T-E | Human | Esophagus | ESCC | 1.41e-21 | 4.37e-01 | 0.116 |
29785 | CYP2S1 | P11T-E | Human | Esophagus | ESCC | 1.01e-14 | 1.16e+00 | 0.1426 |
29785 | CYP2S1 | P12T-E | Human | Esophagus | ESCC | 5.78e-83 | 1.77e+00 | 0.1122 |
29785 | CYP2S1 | P15T-E | Human | Esophagus | ESCC | 5.11e-53 | 1.41e+00 | 0.1149 |
29785 | CYP2S1 | P17T-E | Human | Esophagus | ESCC | 1.25e-03 | 2.88e-01 | 0.1278 |
29785 | CYP2S1 | P20T-E | Human | Esophagus | ESCC | 1.51e-10 | 5.05e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066929 | Esophagus | HGIN | prostanoid metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
GO:00066939 | Esophagus | HGIN | prostaglandin metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:000669211 | Esophagus | ESCC | prostanoid metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:000669311 | Esophagus | ESCC | prostaglandin metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:000941018 | Oral cavity | OSCC | response to xenobiotic stimulus | 222/7305 | 462/18723 | 4.00e-05 | 3.48e-04 | 222 |
GO:00066317 | Oral cavity | OSCC | fatty acid metabolic process | 186/7305 | 390/18723 | 2.65e-04 | 1.69e-03 | 186 |
GO:00066928 | Oral cavity | OSCC | prostanoid metabolic process | 29/7305 | 49/18723 | 3.33e-03 | 1.42e-02 | 29 |
GO:00066938 | Oral cavity | OSCC | prostaglandin metabolic process | 29/7305 | 49/18723 | 3.33e-03 | 1.42e-02 | 29 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:000941019 | Oral cavity | LP | response to xenobiotic stimulus | 141/4623 | 462/18723 | 2.33e-03 | 1.68e-02 | 141 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYP2S1 | SNV | Missense_Mutation | rs759878389 | c.1502N>T | p.Thr501Met | p.T501M | Q96SQ9 | protein_coding | tolerated_low_confidence(0.07) | benign(0) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CYP2S1 | SNV | Missense_Mutation | rs778416663 | c.749N>A | p.Arg250Gln | p.R250Q | Q96SQ9 | protein_coding | tolerated(0.42) | benign(0) | TCGA-A5-A1OG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
CYP2S1 | SNV | Missense_Mutation | c.214N>A | p.Leu72Met | p.L72M | Q96SQ9 | protein_coding | tolerated(0.08) | possibly_damaging(0.84) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYP2S1 | SNV | Missense_Mutation | c.361G>A | p.Gly121Arg | p.G121R | Q96SQ9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYP2S1 | SNV | Missense_Mutation | c.1069C>A | p.Leu357Met | p.L357M | Q96SQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYP2S1 | SNV | Missense_Mutation | novel | c.691C>T | p.Pro231Ser | p.P231S | Q96SQ9 | protein_coding | deleterious(0.02) | benign(0.098) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP2S1 | SNV | Missense_Mutation | novel | c.1294C>T | p.Pro432Ser | p.P432S | Q96SQ9 | protein_coding | deleterious(0.02) | probably_damaging(0.965) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP2S1 | SNV | Missense_Mutation | rs149333675 | c.1079N>T | p.Ala360Val | p.A360V | Q96SQ9 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYP2S1 | SNV | Missense_Mutation | rs201452317 | c.461N>A | p.Arg154Gln | p.R154Q | Q96SQ9 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CYP2S1 | SNV | Missense_Mutation | rs752402676 | c.367C>T | p.Arg123Trp | p.R123W | Q96SQ9 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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