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Gene: CXorf38 |
Gene summary for CXORF38 |
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Gene information | Species | Human | Gene symbol | CXorf38 | Gene ID | 159013 |
Gene name | chromosome X open reading frame 38 | |
Gene Alias | CXorf38 | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8TB03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
159013 | CXorf38 | LZE4T | Human | Esophagus | ESCC | 2.52e-03 | 1.57e-01 | 0.0811 |
159013 | CXorf38 | P2T-E | Human | Esophagus | ESCC | 4.65e-29 | 5.44e-01 | 0.1177 |
159013 | CXorf38 | P4T-E | Human | Esophagus | ESCC | 2.61e-14 | 3.44e-01 | 0.1323 |
159013 | CXorf38 | P5T-E | Human | Esophagus | ESCC | 1.73e-17 | 2.74e-01 | 0.1327 |
159013 | CXorf38 | P8T-E | Human | Esophagus | ESCC | 2.13e-18 | 3.73e-01 | 0.0889 |
159013 | CXorf38 | P10T-E | Human | Esophagus | ESCC | 6.65e-10 | 1.04e-01 | 0.116 |
159013 | CXorf38 | P11T-E | Human | Esophagus | ESCC | 3.35e-05 | 2.69e-01 | 0.1426 |
159013 | CXorf38 | P12T-E | Human | Esophagus | ESCC | 1.91e-06 | 1.18e-01 | 0.1122 |
159013 | CXorf38 | P15T-E | Human | Esophagus | ESCC | 2.84e-04 | 1.49e-01 | 0.1149 |
159013 | CXorf38 | P16T-E | Human | Esophagus | ESCC | 3.38e-20 | 3.25e-01 | 0.1153 |
159013 | CXorf38 | P20T-E | Human | Esophagus | ESCC | 2.90e-08 | 2.30e-01 | 0.1124 |
159013 | CXorf38 | P21T-E | Human | Esophagus | ESCC | 3.10e-15 | 1.91e-01 | 0.1617 |
159013 | CXorf38 | P23T-E | Human | Esophagus | ESCC | 2.84e-08 | 2.37e-01 | 0.108 |
159013 | CXorf38 | P24T-E | Human | Esophagus | ESCC | 2.68e-10 | 1.07e-01 | 0.1287 |
159013 | CXorf38 | P26T-E | Human | Esophagus | ESCC | 7.82e-13 | 3.70e-01 | 0.1276 |
159013 | CXorf38 | P27T-E | Human | Esophagus | ESCC | 2.87e-08 | 1.78e-01 | 0.1055 |
159013 | CXorf38 | P28T-E | Human | Esophagus | ESCC | 5.31e-12 | 2.63e-01 | 0.1149 |
159013 | CXorf38 | P30T-E | Human | Esophagus | ESCC | 1.16e-17 | 6.15e-01 | 0.137 |
159013 | CXorf38 | P31T-E | Human | Esophagus | ESCC | 4.31e-03 | 9.80e-02 | 0.1251 |
159013 | CXorf38 | P32T-E | Human | Esophagus | ESCC | 6.76e-07 | 1.63e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CXorf38 | SNV | Missense_Mutation | c.293N>C | p.Val98Ala | p.V98A | Q8TB03 | protein_coding | deleterious(0) | benign(0.258) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CXorf38 | SNV | Missense_Mutation | novel | c.393N>T | p.Glu131Asp | p.E131D | Q8TB03 | protein_coding | tolerated(0.38) | benign(0.08) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CXorf38 | SNV | Missense_Mutation | novel | c.576N>A | p.Phe192Leu | p.F192L | Q8TB03 | protein_coding | tolerated(0.18) | probably_damaging(0.99) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXorf38 | SNV | Missense_Mutation | rs768158728 | c.455N>A | p.Arg152Gln | p.R152Q | Q8TB03 | protein_coding | tolerated(0.4) | benign(0.073) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXorf38 | SNV | Missense_Mutation | novel | c.188N>A | p.Gly63Asp | p.G63D | Q8TB03 | protein_coding | deleterious(0.02) | benign(0.127) | TCGA-3K-AAZ8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
CXorf38 | SNV | Missense_Mutation | c.457A>C | p.Lys153Gln | p.K153Q | Q8TB03 | protein_coding | tolerated(0.09) | benign(0.347) | TCGA-DD-A73F-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CXorf38 | SNV | Missense_Mutation | c.334N>T | p.Ala112Ser | p.A112S | Q8TB03 | protein_coding | tolerated(0.61) | benign(0.017) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CXorf38 | SNV | Missense_Mutation | c.679N>A | p.Glu227Lys | p.E227K | Q8TB03 | protein_coding | deleterious(0.05) | benign(0.015) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
CXorf38 | SNV | Missense_Mutation | novel | c.85N>T | p.Arg29Cys | p.R29C | Q8TB03 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CXorf38 | SNV | Missense_Mutation | c.589G>C | p.Glu197Gln | p.E197Q | Q8TB03 | protein_coding | tolerated(0.06) | possibly_damaging(0.776) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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