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Gene: CSTF3 |
Gene summary for CSTF3 |
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Gene information | Species | Human | Gene symbol | CSTF3 | Gene ID | 1479 |
Gene name | cleavage stimulation factor subunit 3 | |
Gene Alias | CSTF-77 | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q12996 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1479 | CSTF3 | S43 | Human | Liver | Cirrhotic | 1.12e-05 | -1.25e-01 | -0.0187 |
1479 | CSTF3 | HCC1_Meng | Human | Liver | HCC | 6.44e-58 | 4.72e-03 | 0.0246 |
1479 | CSTF3 | HCC2_Meng | Human | Liver | HCC | 1.70e-07 | -6.71e-02 | 0.0107 |
1479 | CSTF3 | HCC1 | Human | Liver | HCC | 2.77e-04 | 3.31e+00 | 0.5336 |
1479 | CSTF3 | Pt13.b | Human | Liver | HCC | 4.74e-02 | 7.09e-02 | 0.0251 |
1479 | CSTF3 | Pt14.a | Human | Liver | HCC | 3.96e-03 | 3.11e-01 | 0.0169 |
1479 | CSTF3 | S028 | Human | Liver | HCC | 1.30e-06 | 4.84e-01 | 0.2503 |
1479 | CSTF3 | S029 | Human | Liver | HCC | 2.97e-08 | 6.78e-01 | 0.2581 |
1479 | CSTF3 | C04 | Human | Oral cavity | OSCC | 5.40e-19 | 8.74e-01 | 0.2633 |
1479 | CSTF3 | C21 | Human | Oral cavity | OSCC | 1.12e-39 | 1.13e+00 | 0.2678 |
1479 | CSTF3 | C30 | Human | Oral cavity | OSCC | 8.25e-27 | 1.04e+00 | 0.3055 |
1479 | CSTF3 | C38 | Human | Oral cavity | OSCC | 6.63e-03 | 6.29e-01 | 0.172 |
1479 | CSTF3 | C43 | Human | Oral cavity | OSCC | 1.00e-11 | 2.69e-01 | 0.1704 |
1479 | CSTF3 | C46 | Human | Oral cavity | OSCC | 5.29e-26 | 5.94e-01 | 0.1673 |
1479 | CSTF3 | C51 | Human | Oral cavity | OSCC | 8.30e-23 | 9.31e-01 | 0.2674 |
1479 | CSTF3 | C57 | Human | Oral cavity | OSCC | 2.60e-15 | 6.04e-01 | 0.1679 |
1479 | CSTF3 | C07 | Human | Oral cavity | OSCC | 8.44e-05 | 9.02e-01 | 0.2491 |
1479 | CSTF3 | C08 | Human | Oral cavity | OSCC | 1.16e-15 | 3.45e-01 | 0.1919 |
1479 | CSTF3 | LN22 | Human | Oral cavity | OSCC | 1.29e-02 | 4.46e-01 | 0.1733 |
1479 | CSTF3 | LN38 | Human | Oral cavity | OSCC | 2.05e-02 | 5.18e-01 | 0.168 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
GO:0031123 | Liver | Cirrhotic | RNA 3'-end processing | 42/4634 | 116/18723 | 3.85e-03 | 2.10e-02 | 42 |
GO:0031124 | Liver | Cirrhotic | mRNA 3'-end processing | 25/4634 | 62/18723 | 4.90e-03 | 2.56e-02 | 25 |
GO:00311241 | Liver | HCC | mRNA 3'-end processing | 50/7958 | 62/18723 | 8.44e-10 | 2.60e-08 | 50 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0006378 | Liver | HCC | mRNA polyadenylation | 35/7958 | 44/18723 | 5.70e-07 | 9.03e-06 | 35 |
GO:0043631 | Liver | HCC | RNA polyadenylation | 35/7958 | 45/18723 | 1.51e-06 | 2.15e-05 | 35 |
GO:0006379 | Liver | HCC | mRNA cleavage | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
GO:00311242 | Oral cavity | OSCC | mRNA 3'-end processing | 49/7305 | 62/18723 | 1.40e-10 | 4.14e-09 | 49 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
GO:00063782 | Oral cavity | OSCC | mRNA polyadenylation | 34/7305 | 44/18723 | 2.63e-07 | 4.10e-06 | 34 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00436312 | Oral cavity | OSCC | RNA polyadenylation | 34/7305 | 45/18723 | 6.73e-07 | 9.53e-06 | 34 |
GO:00063792 | Oral cavity | OSCC | mRNA cleavage | 18/7305 | 22/18723 | 5.05e-05 | 4.23e-04 | 18 |
GO:009050111 | Oral cavity | LP | RNA phosphodiester bond hydrolysis | 63/4623 | 152/18723 | 3.88e-06 | 8.13e-05 | 63 |
GO:003112311 | Oral cavity | LP | RNA 3'-end processing | 48/4623 | 116/18723 | 5.51e-05 | 7.58e-04 | 48 |
GO:00903051 | Oral cavity | LP | nucleic acid phosphodiester bond hydrolysis | 92/4623 | 261/18723 | 8.07e-05 | 1.04e-03 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030154 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa0301511 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0301531 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa030158 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301523 | Oral cavity | LP | mRNA surveillance pathway | 50/2418 | 97/8465 | 1.39e-06 | 1.50e-05 | 9.66e-06 | 50 |
hsa0301533 | Oral cavity | LP | mRNA surveillance pathway | 50/2418 | 97/8465 | 1.39e-06 | 1.50e-05 | 9.66e-06 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSTF3 | SNV | Missense_Mutation | c.970G>A | p.Ala324Thr | p.A324T | Q12996 | protein_coding | tolerated(0.31) | possibly_damaging(0.483) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
CSTF3 | SNV | Missense_Mutation | novel | c.1418N>G | p.Ser473Cys | p.S473C | Q12996 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CSTF3 | SNV | Missense_Mutation | c.1580N>C | p.Arg527Thr | p.R527T | Q12996 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CSTF3 | SNV | Missense_Mutation | novel | c.69N>T | p.Lys23Asn | p.K23N | Q12996 | protein_coding | tolerated(0.13) | benign(0.339) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CSTF3 | SNV | Missense_Mutation | rs749330202 | c.1931N>A | p.Arg644Gln | p.R644Q | Q12996 | protein_coding | tolerated(0.66) | benign(0.253) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CSTF3 | SNV | Missense_Mutation | c.397A>T | p.Ile133Phe | p.I133F | Q12996 | protein_coding | deleterious(0) | possibly_damaging(0.732) | TCGA-AG-A011-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CSTF3 | insertion | Frame_Shift_Ins | novel | c.364_365insA | p.Met122AsnfsTer6 | p.M122Nfs*6 | Q12996 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
CSTF3 | insertion | Frame_Shift_Ins | novel | c.613dupA | p.Met205AsnfsTer3 | p.M205Nfs*3 | Q12996 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CSTF3 | insertion | Frame_Shift_Ins | novel | c.749_750insAAATTTTAGTAACC | p.Asp250GlufsTer28 | p.D250Efs*28 | Q12996 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CSTF3 | SNV | Missense_Mutation | rs757337076 | c.2020G>A | p.Val674Met | p.V674M | Q12996 | protein_coding | tolerated(0.26) | benign(0.022) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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