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Gene: CREB3L1 |
Gene summary for CREB3L1 |
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Gene information | Species | Human | Gene symbol | CREB3L1 | Gene ID | 90993 |
Gene name | cAMP responsive element binding protein 3 like 1 | |
Gene Alias | OASIS | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B2RA75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90993 | CREB3L1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.43e-02 | 1.83e-01 | 0.0155 |
90993 | CREB3L1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.66e-14 | 9.42e-01 | -0.1808 |
90993 | CREB3L1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.15e-14 | 7.98e-01 | -0.0811 |
90993 | CREB3L1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.30e-19 | 9.32e-01 | -0.1088 |
90993 | CREB3L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.20e-36 | 1.03e+00 | -0.1954 |
90993 | CREB3L1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-15 | 1.85e+00 | -0.2602 |
90993 | CREB3L1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.16e-06 | 1.22e+00 | -0.2196 |
90993 | CREB3L1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.01e-08 | 7.33e-01 | -0.1207 |
90993 | CREB3L1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.19e-32 | 1.11e+00 | -0.1464 |
90993 | CREB3L1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-18 | 9.37e-01 | -0.1001 |
90993 | CREB3L1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.67e-16 | 6.72e-01 | -0.059 |
90993 | CREB3L1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.06e-03 | 6.53e-01 | -0.1706 |
90993 | CREB3L1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.66e-04 | 5.78e-01 | -0.2061 |
90993 | CREB3L1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.21e-07 | 8.13e-01 | -0.0842 |
90993 | CREB3L1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.29e-05 | 7.10e-01 | 0.0446 |
90993 | CREB3L1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.30e-05 | 5.37e-01 | -0.0177 |
90993 | CREB3L1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.72e-05 | 5.80e-01 | 0.0112 |
90993 | CREB3L1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.54e-06 | 4.61e-01 | 0.0588 |
90993 | CREB3L1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.44e-03 | 2.99e-01 | 0.281 |
90993 | CREB3L1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.97e-04 | -2.33e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0035967 | Colorectum | AD | cellular response to topologically incorrect protein | 42/3918 | 116/18723 | 1.04e-04 | 1.56e-03 | 42 |
GO:1905897 | Colorectum | AD | regulation of response to endoplasmic reticulum stress | 32/3918 | 82/18723 | 1.37e-04 | 1.95e-03 | 32 |
GO:0043620 | Colorectum | AD | regulation of DNA-templated transcription in response to stress | 23/3918 | 53/18723 | 1.86e-04 | 2.49e-03 | 23 |
GO:0036003 | Colorectum | AD | positive regulation of transcription from RNA polymerase II promoter in response to stress | 13/3918 | 24/18723 | 3.45e-04 | 4.03e-03 | 13 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0043618 | Colorectum | AD | regulation of transcription from RNA polymerase II promoter in response to stress | 20/3918 | 47/18723 | 6.54e-04 | 6.75e-03 | 20 |
GO:0006986 | Colorectum | AD | response to unfolded protein | 45/3918 | 137/18723 | 7.43e-04 | 7.48e-03 | 45 |
GO:1902236 | Colorectum | AD | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:0034620 | Colorectum | AD | cellular response to unfolded protein | 33/3918 | 96/18723 | 1.53e-03 | 1.29e-02 | 33 |
GO:1903573 | Colorectum | AD | negative regulation of response to endoplasmic reticulum stress | 18/3918 | 44/18723 | 2.06e-03 | 1.64e-02 | 18 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:20012421 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway | 59/2897 | 164/18723 | 8.42e-11 | 1.20e-08 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa04962 | Colorectum | AD | Vasopressin-regulated water reabsorption | 19/2092 | 44/8465 | 5.48e-03 | 2.48e-02 | 1.58e-02 | 19 |
hsa04728 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa05215 | Colorectum | AD | Prostate cancer | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa050201 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa051661 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa049621 | Colorectum | AD | Vasopressin-regulated water reabsorption | 19/2092 | 44/8465 | 5.48e-03 | 2.48e-02 | 1.58e-02 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CREB3L1 | SNV | Missense_Mutation | rs375217169 | c.412N>A | p.Val138Met | p.V138M | Q96BA8 | protein_coding | tolerated(0.25) | benign(0.005) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREB3L1 | SNV | Missense_Mutation | rs771754544 | c.668N>A | p.Arg223His | p.R223H | Q96BA8 | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CREB3L1 | SNV | Missense_Mutation | c.1271N>A | p.Ser424Asn | p.S424N | Q96BA8 | protein_coding | tolerated(0.3) | probably_damaging(0.954) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CREB3L1 | SNV | Missense_Mutation | novel | c.984G>T | p.Glu328Asp | p.E328D | Q96BA8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CREB3L1 | SNV | Missense_Mutation | novel | c.986N>G | p.Asn329Ser | p.N329S | Q96BA8 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
CREB3L1 | SNV | Missense_Mutation | c.604G>A | p.Val202Met | p.V202M | Q96BA8 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
CREB3L1 | SNV | Missense_Mutation | novel | c.815N>T | p.Ala272Val | p.A272V | Q96BA8 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CREB3L1 | SNV | Missense_Mutation | c.1191N>A | p.Phe397Leu | p.F397L | Q96BA8 | protein_coding | tolerated(0.25) | benign(0.444) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CREB3L1 | SNV | Missense_Mutation | novel | c.170G>A | p.Ser57Asn | p.S57N | Q96BA8 | protein_coding | tolerated(0.15) | probably_damaging(0.968) | TCGA-D1-A1NW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CREB3L1 | SNV | Missense_Mutation | novel | c.428N>T | p.Ala143Val | p.A143V | Q96BA8 | protein_coding | tolerated(0.53) | benign(0.14) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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