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Gene: CRABP2 |
Gene summary for CRABP2 |
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Gene information | Species | Human | Gene symbol | CRABP2 | Gene ID | 1382 |
Gene name | cellular retinoic acid binding protein 2 | |
Gene Alias | CRABP-II | |
Cytomap | 1q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P29373 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1382 | CRABP2 | GSM4909281 | Human | Breast | IDC | 2.46e-02 | -3.33e-01 | 0.21 |
1382 | CRABP2 | GSM4909282 | Human | Breast | IDC | 4.59e-31 | 6.86e-01 | -0.0288 |
1382 | CRABP2 | GSM4909285 | Human | Breast | IDC | 3.22e-53 | 8.42e-01 | 0.21 |
1382 | CRABP2 | GSM4909287 | Human | Breast | IDC | 7.06e-10 | -5.19e-01 | 0.2057 |
1382 | CRABP2 | GSM4909288 | Human | Breast | IDC | 5.71e-08 | -7.66e-01 | 0.0988 |
1382 | CRABP2 | GSM4909289 | Human | Breast | IDC | 5.60e-13 | 8.41e-01 | 0.1064 |
1382 | CRABP2 | GSM4909290 | Human | Breast | IDC | 2.00e-20 | -7.49e-01 | 0.2096 |
1382 | CRABP2 | GSM4909293 | Human | Breast | IDC | 7.13e-05 | 1.68e-01 | 0.1581 |
1382 | CRABP2 | GSM4909294 | Human | Breast | IDC | 3.66e-03 | -3.54e-01 | 0.2022 |
1382 | CRABP2 | GSM4909297 | Human | Breast | IDC | 1.97e-15 | 3.10e-01 | 0.1517 |
1382 | CRABP2 | GSM4909298 | Human | Breast | IDC | 8.69e-07 | 3.09e-01 | 0.1551 |
1382 | CRABP2 | GSM4909304 | Human | Breast | IDC | 1.58e-37 | -8.29e-01 | 0.1636 |
1382 | CRABP2 | GSM4909305 | Human | Breast | IDC | 2.12e-02 | 3.22e-01 | 0.0436 |
1382 | CRABP2 | GSM4909306 | Human | Breast | IDC | 1.95e-39 | 7.26e-01 | 0.1564 |
1382 | CRABP2 | GSM4909307 | Human | Breast | IDC | 4.43e-46 | 8.19e-01 | 0.1569 |
1382 | CRABP2 | GSM4909308 | Human | Breast | IDC | 1.50e-51 | 8.52e-01 | 0.158 |
1382 | CRABP2 | GSM4909311 | Human | Breast | IDC | 1.19e-19 | 2.20e-02 | 0.1534 |
1382 | CRABP2 | GSM4909315 | Human | Breast | IDC | 4.93e-09 | -5.47e-01 | 0.21 |
1382 | CRABP2 | GSM4909319 | Human | Breast | IDC | 5.79e-41 | 3.14e-01 | 0.1563 |
1382 | CRABP2 | GSM4909320 | Human | Breast | IDC | 4.99e-13 | 5.80e-01 | 0.1575 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:00015587 | Breast | Precancer | regulation of cell growth | 39/1080 | 414/18723 | 1.81e-03 | 1.78e-02 | 39 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:001604913 | Breast | IDC | cell growth | 56/1434 | 482/18723 | 1.16e-03 | 1.26e-02 | 56 |
GO:000155813 | Breast | IDC | regulation of cell growth | 49/1434 | 414/18723 | 1.55e-03 | 1.55e-02 | 49 |
GO:00325358 | Breast | IDC | regulation of cellular component size | 45/1434 | 383/18723 | 2.72e-03 | 2.41e-02 | 45 |
GO:000854422 | Breast | DCIS | epidermis development | 40/1390 | 324/18723 | 1.05e-03 | 1.16e-02 | 40 |
GO:001604923 | Breast | DCIS | cell growth | 54/1390 | 482/18723 | 1.60e-03 | 1.59e-02 | 54 |
GO:000155822 | Breast | DCIS | regulation of cell growth | 47/1390 | 414/18723 | 2.39e-03 | 2.16e-02 | 47 |
GO:003253514 | Breast | DCIS | regulation of cellular component size | 44/1390 | 383/18723 | 2.58e-03 | 2.30e-02 | 44 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00107206 | Cervix | CC | positive regulation of cell development | 64/2311 | 298/18723 | 5.69e-06 | 1.41e-04 | 64 |
GO:00313467 | Cervix | CC | positive regulation of cell projection organization | 72/2311 | 353/18723 | 1.04e-05 | 2.32e-04 | 72 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRABP2 | SNV | Missense_Mutation | c.287N>C | p.Cys96Ser | p.C96S | P29373 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CRABP2 | SNV | Missense_Mutation | rs771785983 | c.178C>T | p.Arg60Cys | p.R60C | P29373 | protein_coding | deleterious(0.02) | benign(0.081) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CRABP2 | SNV | Missense_Mutation | c.281N>C | p.Met94Thr | p.M94T | P29373 | protein_coding | deleterious(0) | benign(0.268) | TCGA-69-8254-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CRABP2 | SNV | Missense_Mutation | c.355N>A | p.Glu119Lys | p.E119K | P29373 | protein_coding | tolerated(0.1) | benign(0.088) | TCGA-71-6725-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CRABP2 | SNV | Missense_Mutation | c.35G>A | p.Arg12Gln | p.R12Q | P29373 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-43-6770-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Vaccine | recprame+as15 | SD | |
CRABP2 | SNV | Missense_Mutation | novel | c.83N>G | p.Met28Arg | p.M28R | P29373 | protein_coding | deleterious(0.03) | possibly_damaging(0.741) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CRABP2 | SNV | Missense_Mutation | novel | c.140N>T | p.Glu47Val | p.E47V | P29373 | protein_coding | deleterious(0) | benign(0.049) | TCGA-CR-6491-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
CRABP2 | SNV | Missense_Mutation | c.54N>T | p.Glu18Asp | p.E18D | P29373 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-BR-8676-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CRABP2 | SNV | Missense_Mutation | c.58N>T | p.Leu20Phe | p.L20F | P29373 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1382 | CRABP2 | NA | RETINOID | 12153175 | ||
1382 | CRABP2 | NA | BESTATIN METHYL ESTER | BESTATIN METHYL ESTER | 21515062 |
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