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Gene: CPXM1 |
Gene summary for CPXM1 |
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Gene information | Species | Human | Gene symbol | CPXM1 | Gene ID | 56265 |
Gene name | carboxypeptidase X, M14 family member 1 | |
Gene Alias | CPX1 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q96SM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56265 | CPXM1 | AEH-subject1 | Human | Endometrium | AEH | 7.18e-27 | -5.98e-01 | -0.3059 |
56265 | CPXM1 | AEH-subject2 | Human | Endometrium | AEH | 3.88e-43 | -6.46e-01 | -0.2525 |
56265 | CPXM1 | AEH-subject3 | Human | Endometrium | AEH | 3.36e-25 | -5.95e-01 | -0.2576 |
56265 | CPXM1 | AEH-subject4 | Human | Endometrium | AEH | 3.71e-14 | -5.31e-01 | -0.2657 |
56265 | CPXM1 | AEH-subject5 | Human | Endometrium | AEH | 5.13e-39 | -6.75e-01 | -0.2953 |
56265 | CPXM1 | EEC-subject1 | Human | Endometrium | EEC | 5.58e-35 | -6.69e-01 | -0.2682 |
56265 | CPXM1 | EEC-subject2 | Human | Endometrium | EEC | 3.33e-41 | -6.74e-01 | -0.2607 |
56265 | CPXM1 | EEC-subject3 | Human | Endometrium | EEC | 5.57e-41 | -6.63e-01 | -0.2525 |
56265 | CPXM1 | EEC-subject4 | Human | Endometrium | EEC | 2.22e-30 | -6.25e-01 | -0.2571 |
56265 | CPXM1 | EEC-subject5 | Human | Endometrium | EEC | 1.87e-39 | -6.74e-01 | -0.249 |
56265 | CPXM1 | GSM5276935 | Human | Endometrium | EEC | 9.25e-41 | -6.76e-01 | -0.123 |
56265 | CPXM1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.15e-33 | -6.82e-01 | -0.1869 |
56265 | CPXM1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.70e-30 | -6.82e-01 | -0.1875 |
56265 | CPXM1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.11e-31 | -6.70e-01 | -0.1883 |
56265 | CPXM1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.75e-43 | -6.82e-01 | -0.1934 |
56265 | CPXM1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.92e-44 | -6.82e-01 | -0.1917 |
56265 | CPXM1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.11e-44 | -6.82e-01 | -0.1916 |
56265 | CPXM1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 6.15e-12 | -4.93e-01 | -0.1269 |
56265 | CPXM1 | P2T-E | Human | Esophagus | ESCC | 4.91e-22 | 5.78e-01 | 0.1177 |
56265 | CPXM1 | P4T-E | Human | Esophagus | ESCC | 3.53e-08 | 2.20e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPXM1 | SNV | Missense_Mutation | novel | c.575N>T | p.Arg192Met | p.R192M | Q96SM3 | protein_coding | deleterious(0) | possibly_damaging(0.708) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CPXM1 | SNV | Missense_Mutation | novel | c.1304N>G | p.His435Arg | p.H435R | Q96SM3 | protein_coding | tolerated(0.67) | probably_damaging(0.998) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CPXM1 | SNV | Missense_Mutation | c.940N>C | p.Glu314Gln | p.E314Q | Q96SM3 | protein_coding | tolerated(0.05) | benign(0.108) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CPXM1 | SNV | Missense_Mutation | novel | c.1360N>A | p.Pro454Thr | p.P454T | Q96SM3 | protein_coding | deleterious(0.01) | benign(0.111) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CPXM1 | SNV | Missense_Mutation | novel | c.966N>G | p.Ile322Met | p.I322M | Q96SM3 | protein_coding | deleterious(0.01) | possibly_damaging(0.725) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CPXM1 | SNV | Missense_Mutation | c.337N>G | p.Thr113Ala | p.T113A | Q96SM3 | protein_coding | tolerated(0.29) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CPXM1 | SNV | Missense_Mutation | c.688C>A | p.Pro230Thr | p.P230T | Q96SM3 | protein_coding | tolerated(0.37) | possibly_damaging(0.551) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CPXM1 | SNV | Missense_Mutation | c.1725G>T | p.Met575Ile | p.M575I | Q96SM3 | protein_coding | tolerated(0.12) | benign(0.363) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPXM1 | SNV | Missense_Mutation | c.865T>C | p.Ser289Pro | p.S289P | Q96SM3 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPXM1 | SNV | Missense_Mutation | c.604N>G | p.Thr202Ala | p.T202A | Q96SM3 | protein_coding | deleterious(0.02) | benign(0.192) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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