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Gene: CPLX2 |
Gene summary for CPLX2 |
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Gene information | Species | Human | Gene symbol | CPLX2 | Gene ID | 10814 |
Gene name | complexin 2 | |
Gene Alias | 921-L | |
Cytomap | 5q35.2 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q6PUV4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10814 | CPLX2 | HCC1 | Human | Liver | HCC | 9.85e-15 | 5.19e+00 | 0.5336 |
10814 | CPLX2 | HCC2 | Human | Liver | HCC | 2.51e-23 | 3.20e+00 | 0.5341 |
10814 | CPLX2 | S014 | Human | Liver | HCC | 9.97e-44 | 1.78e+00 | 0.2254 |
10814 | CPLX2 | S015 | Human | Liver | HCC | 3.28e-44 | 2.47e+00 | 0.2375 |
10814 | CPLX2 | S016 | Human | Liver | HCC | 1.55e-66 | 2.05e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:002240611 | Liver | HCC | membrane docking | 57/7958 | 86/18723 | 7.14e-06 | 8.47e-05 | 57 |
GO:004828411 | Liver | HCC | organelle fusion | 84/7958 | 141/18723 | 3.13e-05 | 3.20e-04 | 84 |
GO:014005611 | Liver | HCC | organelle localization by membrane tethering | 49/7958 | 77/18723 | 1.46e-04 | 1.18e-03 | 49 |
GO:00901741 | Liver | HCC | organelle membrane fusion | 63/7958 | 110/18723 | 1.24e-03 | 6.85e-03 | 63 |
GO:00069061 | Liver | HCC | vesicle fusion | 61/7958 | 106/18723 | 1.25e-03 | 6.90e-03 | 61 |
GO:0061025 | Liver | HCC | membrane fusion | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:0048278 | Liver | HCC | vesicle docking | 34/7958 | 59/18723 | 1.36e-02 | 4.84e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPLX2 | SNV | Missense_Mutation | novel | c.243N>T | p.Glu81Asp | p.E81D | Q6PUV4 | protein_coding | tolerated(0.09) | probably_damaging(0.973) | TCGA-75-7025-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
CPLX2 | SNV | Missense_Mutation | c.31G>T | p.Gly11Trp | p.G11W | Q6PUV4 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
CPLX2 | SNV | Missense_Mutation | c.262C>A | p.Gln88Lys | p.Q88K | Q6PUV4 | protein_coding | tolerated(0.68) | benign(0.049) | TCGA-34-A5IX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CPLX2 | SNV | Missense_Mutation | novel | c.354N>A | p.Asp118Glu | p.D118E | Q6PUV4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.165) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CPLX2 | SNV | Missense_Mutation | novel | c.257N>A | p.Leu86Gln | p.L86Q | Q6PUV4 | protein_coding | tolerated(0.08) | benign(0.414) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CPLX2 | SNV | Missense_Mutation | c.319N>A | p.Asp107Asn | p.D107N | Q6PUV4 | protein_coding | deleterious(0) | benign(0.036) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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