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Gene: CPE |
Gene summary for CPE |
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Gene information | Species | Human | Gene symbol | CPE | Gene ID | 1363 |
Gene name | carboxypeptidase E | |
Gene Alias | CPH | |
Cytomap | 4q32.3 | |
Gene Type | protein-coding | GO ID | GO:0003007 | UniProtAcc | P16870 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1363 | CPE | CA_HPV_3 | Human | Cervix | CC | 8.55e-36 | 5.94e-01 | 0.0414 |
1363 | CPE | sample1 | Human | Cervix | CC | 4.46e-16 | 6.90e-01 | 0.0959 |
1363 | CPE | T1 | Human | Cervix | CC | 4.63e-33 | 7.44e-01 | 0.0918 |
1363 | CPE | LZE24T | Human | Esophagus | ESCC | 2.55e-02 | -2.78e-01 | 0.0596 |
1363 | CPE | P2T-E | Human | Esophagus | ESCC | 2.69e-89 | 2.53e+00 | 0.1177 |
1363 | CPE | P4T-E | Human | Esophagus | ESCC | 1.66e-20 | 7.59e-01 | 0.1323 |
1363 | CPE | P10T-E | Human | Esophagus | ESCC | 4.97e-12 | 2.95e-01 | 0.116 |
1363 | CPE | P11T-E | Human | Esophagus | ESCC | 4.91e-03 | 4.69e-01 | 0.1426 |
1363 | CPE | P12T-E | Human | Esophagus | ESCC | 3.19e-03 | -2.42e-01 | 0.1122 |
1363 | CPE | P16T-E | Human | Esophagus | ESCC | 2.64e-43 | 1.19e+00 | 0.1153 |
1363 | CPE | P21T-E | Human | Esophagus | ESCC | 3.79e-04 | -1.37e-01 | 0.1617 |
1363 | CPE | P22T-E | Human | Esophagus | ESCC | 2.00e-17 | 4.87e-01 | 0.1236 |
1363 | CPE | P23T-E | Human | Esophagus | ESCC | 1.51e-03 | 4.76e-01 | 0.108 |
1363 | CPE | P26T-E | Human | Esophagus | ESCC | 3.48e-76 | 1.71e+00 | 0.1276 |
1363 | CPE | P28T-E | Human | Esophagus | ESCC | 7.36e-03 | -1.78e-01 | 0.1149 |
1363 | CPE | P31T-E | Human | Esophagus | ESCC | 6.04e-03 | -1.54e-01 | 0.1251 |
1363 | CPE | P32T-E | Human | Esophagus | ESCC | 1.57e-06 | 1.77e-01 | 0.1666 |
1363 | CPE | P37T-E | Human | Esophagus | ESCC | 9.84e-21 | 8.79e-01 | 0.1371 |
1363 | CPE | P39T-E | Human | Esophagus | ESCC | 3.49e-03 | -2.00e-01 | 0.0894 |
1363 | CPE | P40T-E | Human | Esophagus | ESCC | 2.89e-02 | 1.71e-01 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:19001517 | Cervix | CC | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 11/2311 | 18/18723 | 1.37e-06 | 4.55e-05 | 11 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:003425010 | Cervix | CC | positive regulation of cellular amide metabolic process | 40/2311 | 162/18723 | 1.11e-05 | 2.41e-04 | 40 |
GO:00002896 | Cervix | CC | nuclear-transcribed mRNA poly(A) tail shortening | 13/2311 | 29/18723 | 1.48e-05 | 2.93e-04 | 13 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00602119 | Cervix | CC | regulation of nuclear-transcribed mRNA poly(A) tail shortening | 9/2311 | 15/18723 | 1.63e-05 | 3.17e-04 | 9 |
GO:19001536 | Cervix | CC | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 9/2311 | 15/18723 | 1.63e-05 | 3.17e-04 | 9 |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:00009567 | Cervix | CC | nuclear-transcribed mRNA catabolic process | 30/2311 | 112/18723 | 2.60e-05 | 4.37e-04 | 30 |
GO:00602139 | Cervix | CC | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 8/2311 | 13/18723 | 3.85e-05 | 6.05e-04 | 8 |
GO:00002886 | Cervix | CC | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 18/2311 | 56/18723 | 8.42e-05 | 1.13e-03 | 18 |
GO:004572710 | Cervix | CC | positive regulation of translation | 33/2311 | 136/18723 | 9.09e-05 | 1.20e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0494016 | Cervix | CC | Type I diabetes mellitus | 17/1267 | 43/8465 | 7.47e-05 | 5.04e-04 | 2.98e-04 | 17 |
hsa0494017 | Cervix | CC | Type I diabetes mellitus | 17/1267 | 43/8465 | 7.47e-05 | 5.04e-04 | 2.98e-04 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPE | SNV | Missense_Mutation | c.610N>A | p.Glu204Lys | p.E204K | P16870 | protein_coding | tolerated(0.61) | benign(0.136) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CPE | SNV | Missense_Mutation | c.317N>C | p.Glu106Ala | p.E106A | P16870 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CPE | SNV | Missense_Mutation | novel | c.265N>A | p.Leu89Met | p.L89M | P16870 | protein_coding | deleterious(0.01) | benign(0.248) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPE | SNV | Missense_Mutation | novel | c.511N>C | p.Glu171Gln | p.E171Q | P16870 | protein_coding | tolerated(0.14) | benign(0.089) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
CPE | SNV | Missense_Mutation | rs138641684 | c.901N>T | p.Arg301Cys | p.R301C | P16870 | protein_coding | deleterious(0.03) | probably_damaging(0.955) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CPE | SNV | Missense_Mutation | c.712N>T | p.Asp238Tyr | p.D238Y | P16870 | protein_coding | deleterious(0) | possibly_damaging(0.652) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPE | SNV | Missense_Mutation | c.880N>A | p.Asp294Asn | p.D294N | P16870 | protein_coding | tolerated(0.47) | benign(0.151) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPE | SNV | Missense_Mutation | c.751G>T | p.Asp251Tyr | p.D251Y | P16870 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPE | SNV | Missense_Mutation | novel | c.640A>G | p.Asn214Asp | p.N214D | P16870 | protein_coding | tolerated(0.81) | benign(0.06) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPE | SNV | Missense_Mutation | rs141250110 | c.902G>A | p.Arg301His | p.R301H | P16870 | protein_coding | tolerated(0.49) | probably_damaging(0.941) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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