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Gene: COX20 |
Gene summary for COX20 |
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Gene information | Species | Human | Gene symbol | COX20 | Gene ID | 116228 |
Gene name | cytochrome c oxidase assembly factor COX20 | |
Gene Alias | FAM36A | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B3KM21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116228 | COX20 | GSM4909281 | Human | Breast | IDC | 1.39e-23 | 6.13e-01 | 0.21 |
116228 | COX20 | GSM4909287 | Human | Breast | IDC | 1.32e-06 | 3.40e-01 | 0.2057 |
116228 | COX20 | GSM4909288 | Human | Breast | IDC | 1.47e-03 | 3.17e-01 | 0.0988 |
116228 | COX20 | GSM4909293 | Human | Breast | IDC | 2.81e-50 | 8.31e-01 | 0.1581 |
116228 | COX20 | GSM4909296 | Human | Breast | IDC | 8.51e-11 | 2.35e-01 | 0.1524 |
116228 | COX20 | GSM4909297 | Human | Breast | IDC | 1.11e-05 | -1.01e-01 | 0.1517 |
116228 | COX20 | GSM4909298 | Human | Breast | IDC | 6.66e-05 | 2.66e-01 | 0.1551 |
116228 | COX20 | GSM4909301 | Human | Breast | IDC | 5.70e-03 | 3.14e-01 | 0.1577 |
116228 | COX20 | GSM4909304 | Human | Breast | IDC | 2.90e-09 | 3.40e-01 | 0.1636 |
116228 | COX20 | GSM4909306 | Human | Breast | IDC | 1.61e-02 | 2.18e-01 | 0.1564 |
116228 | COX20 | GSM4909307 | Human | Breast | IDC | 1.06e-13 | 5.00e-01 | 0.1569 |
116228 | COX20 | GSM4909308 | Human | Breast | IDC | 6.60e-49 | 8.15e-01 | 0.158 |
116228 | COX20 | GSM4909311 | Human | Breast | IDC | 4.91e-23 | -8.01e-03 | 0.1534 |
116228 | COX20 | GSM4909312 | Human | Breast | IDC | 3.67e-03 | 7.82e-02 | 0.1552 |
116228 | COX20 | GSM4909313 | Human | Breast | IDC | 9.66e-04 | 1.48e-01 | 0.0391 |
116228 | COX20 | GSM4909315 | Human | Breast | IDC | 4.50e-72 | 1.16e+00 | 0.21 |
116228 | COX20 | GSM4909316 | Human | Breast | IDC | 8.63e-20 | 7.76e-01 | 0.21 |
116228 | COX20 | GSM4909319 | Human | Breast | IDC | 4.60e-23 | -1.68e-01 | 0.1563 |
116228 | COX20 | GSM4909320 | Human | Breast | IDC | 4.48e-23 | 7.61e-01 | 0.1575 |
116228 | COX20 | GSM4909321 | Human | Breast | IDC | 1.57e-09 | 4.16e-02 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003310813 | Breast | IDC | mitochondrial respiratory chain complex assembly | 28/1434 | 93/18723 | 1.54e-10 | 1.83e-08 | 28 |
GO:003310823 | Breast | DCIS | mitochondrial respiratory chain complex assembly | 28/1390 | 93/18723 | 7.50e-11 | 9.43e-09 | 28 |
GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
GO:00170044 | Esophagus | HGIN | cytochrome complex assembly | 18/2587 | 36/18723 | 2.39e-07 | 1.14e-05 | 18 |
GO:00336173 | Esophagus | HGIN | mitochondrial cytochrome c oxidase assembly | 13/2587 | 22/18723 | 9.51e-07 | 3.80e-05 | 13 |
GO:00085353 | Esophagus | HGIN | respiratory chain complex IV assembly | 14/2587 | 26/18723 | 1.68e-06 | 6.29e-05 | 14 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
GO:000853512 | Esophagus | ESCC | respiratory chain complex IV assembly | 24/8552 | 26/18723 | 6.87e-07 | 8.99e-06 | 24 |
GO:003361712 | Esophagus | ESCC | mitochondrial cytochrome c oxidase assembly | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
GO:00331087 | Liver | Cirrhotic | mitochondrial respiratory chain complex assembly | 64/4634 | 93/18723 | 3.85e-19 | 7.79e-17 | 64 |
GO:0017004 | Liver | Cirrhotic | cytochrome complex assembly | 22/4634 | 36/18723 | 3.92e-06 | 6.70e-05 | 22 |
GO:0033617 | Liver | Cirrhotic | mitochondrial cytochrome c oxidase assembly | 14/4634 | 22/18723 | 1.27e-04 | 1.25e-03 | 14 |
GO:0008535 | Liver | Cirrhotic | respiratory chain complex IV assembly | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
GO:00085351 | Liver | HCC | respiratory chain complex IV assembly | 22/7958 | 26/18723 | 1.23e-05 | 1.39e-04 | 22 |
GO:003310822 | Liver | Cyst | mitochondrial respiratory chain complex assembly | 17/496 | 93/18723 | 3.20e-10 | 6.51e-08 | 17 |
GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471414 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0471415 | Liver | Cirrhotic | Thermogenesis | 121/2530 | 232/8465 | 5.70e-13 | 1.36e-11 | 8.36e-12 | 121 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471442 | Liver | Cyst | Thermogenesis | 34/339 | 232/8465 | 3.33e-11 | 8.73e-10 | 7.21e-10 | 34 |
hsa0471452 | Liver | Cyst | Thermogenesis | 34/339 | 232/8465 | 3.33e-11 | 8.73e-10 | 7.21e-10 | 34 |
hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa04714113 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa04714210 | Oral cavity | LP | Thermogenesis | 105/2418 | 232/8465 | 3.14e-08 | 4.98e-07 | 3.21e-07 | 105 |
hsa0471438 | Oral cavity | LP | Thermogenesis | 105/2418 | 232/8465 | 3.14e-08 | 4.98e-07 | 3.21e-07 | 105 |
hsa0471428 | Prostate | BPH | Thermogenesis | 110/1718 | 232/8465 | 5.16e-21 | 1.42e-19 | 8.78e-20 | 110 |
hsa04714112 | Prostate | BPH | Thermogenesis | 110/1718 | 232/8465 | 5.16e-21 | 1.42e-19 | 8.78e-20 | 110 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COX20 | SNV | Missense_Mutation | rs754328791 | c.143N>G | p.Tyr48Cys | p.Y48C | Q5RI15 | protein_coding | deleterious(0.03) | benign(0.091) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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