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Gene: COX19 |
Gene summary for COX19 |
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Gene information | Species | Human | Gene symbol | COX19 | Gene ID | 90639 |
Gene name | cytochrome c oxidase assembly factor COX19 | |
Gene Alias | COX19 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | Q49B96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90639 | COX19 | LZE4T | Human | Esophagus | ESCC | 1.78e-11 | 3.59e-01 | 0.0811 |
90639 | COX19 | LZE5T | Human | Esophagus | ESCC | 1.97e-02 | 2.56e-01 | 0.0514 |
90639 | COX19 | LZE7T | Human | Esophagus | ESCC | 1.68e-08 | 4.14e-01 | 0.0667 |
90639 | COX19 | LZE8T | Human | Esophagus | ESCC | 6.29e-04 | 6.01e-02 | 0.067 |
90639 | COX19 | LZE20T | Human | Esophagus | ESCC | 2.75e-08 | 1.44e-01 | 0.0662 |
90639 | COX19 | LZE21D1 | Human | Esophagus | HGIN | 3.52e-02 | 1.90e-01 | 0.0632 |
90639 | COX19 | LZE22D1 | Human | Esophagus | HGIN | 1.27e-04 | 1.12e-01 | 0.0595 |
90639 | COX19 | LZE22T | Human | Esophagus | ESCC | 7.29e-06 | 4.08e-01 | 0.068 |
90639 | COX19 | LZE24T | Human | Esophagus | ESCC | 6.60e-14 | 2.96e-01 | 0.0596 |
90639 | COX19 | LZE21T | Human | Esophagus | ESCC | 6.43e-05 | 3.82e-01 | 0.0655 |
90639 | COX19 | LZE6T | Human | Esophagus | ESCC | 2.63e-06 | 2.04e-01 | 0.0845 |
90639 | COX19 | P1T-E | Human | Esophagus | ESCC | 1.33e-12 | 5.77e-01 | 0.0875 |
90639 | COX19 | P2T-E | Human | Esophagus | ESCC | 9.55e-26 | 4.20e-01 | 0.1177 |
90639 | COX19 | P4T-E | Human | Esophagus | ESCC | 2.94e-22 | 5.37e-01 | 0.1323 |
90639 | COX19 | P5T-E | Human | Esophagus | ESCC | 4.36e-16 | 2.94e-01 | 0.1327 |
90639 | COX19 | P8T-E | Human | Esophagus | ESCC | 4.68e-24 | 4.10e-01 | 0.0889 |
90639 | COX19 | P9T-E | Human | Esophagus | ESCC | 1.24e-16 | 4.20e-01 | 0.1131 |
90639 | COX19 | P10T-E | Human | Esophagus | ESCC | 7.58e-50 | 7.56e-01 | 0.116 |
90639 | COX19 | P11T-E | Human | Esophagus | ESCC | 5.38e-11 | 4.66e-01 | 0.1426 |
90639 | COX19 | P12T-E | Human | Esophagus | ESCC | 4.17e-23 | 3.77e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
GO:00170044 | Esophagus | HGIN | cytochrome complex assembly | 18/2587 | 36/18723 | 2.39e-07 | 1.14e-05 | 18 |
GO:00336173 | Esophagus | HGIN | mitochondrial cytochrome c oxidase assembly | 13/2587 | 22/18723 | 9.51e-07 | 3.80e-05 | 13 |
GO:00085353 | Esophagus | HGIN | respiratory chain complex IV assembly | 14/2587 | 26/18723 | 1.68e-06 | 6.29e-05 | 14 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
GO:000853512 | Esophagus | ESCC | respiratory chain complex IV assembly | 24/8552 | 26/18723 | 6.87e-07 | 8.99e-06 | 24 |
GO:003361712 | Esophagus | ESCC | mitochondrial cytochrome c oxidase assembly | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:00469169 | Esophagus | ESCC | cellular transition metal ion homeostasis | 70/8552 | 115/18723 | 7.28e-04 | 3.79e-03 | 70 |
GO:00550703 | Esophagus | ESCC | copper ion homeostasis | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00068781 | Esophagus | ESCC | cellular copper ion homeostasis | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
GO:00085351 | Liver | HCC | respiratory chain complex IV assembly | 22/7958 | 26/18723 | 1.23e-05 | 1.39e-04 | 22 |
GO:005507612 | Liver | HCC | transition metal ion homeostasis | 81/7958 | 138/18723 | 8.87e-05 | 7.72e-04 | 81 |
GO:004691611 | Liver | HCC | cellular transition metal ion homeostasis | 67/7958 | 115/18723 | 4.64e-04 | 3.08e-03 | 67 |
GO:0055070 | Liver | HCC | copper ion homeostasis | 14/7958 | 18/18723 | 2.57e-03 | 1.23e-02 | 14 |
GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa04714113 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa04714210 | Oral cavity | LP | Thermogenesis | 105/2418 | 232/8465 | 3.14e-08 | 4.98e-07 | 3.21e-07 | 105 |
hsa0471438 | Oral cavity | LP | Thermogenesis | 105/2418 | 232/8465 | 3.14e-08 | 4.98e-07 | 3.21e-07 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COX19 | SNV | Missense_Mutation | novel | c.104N>G | p.Glu35Gly | p.E35G | Q49B96 | protein_coding | tolerated(0.35) | benign(0.185) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COX19 | SNV | Missense_Mutation | rs779327518 | c.158N>G | p.Lys53Arg | p.K53R | Q49B96 | protein_coding | tolerated(0.52) | benign(0.023) | TCGA-33-AASJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
COX19 | SNV | Missense_Mutation | c.251G>C | p.Gly84Ala | p.G84A | Q49B96 | protein_coding | tolerated(0.33) | benign(0.034) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
COX19 | SNV | Missense_Mutation | rs774371118 | c.121N>T | p.Leu41Phe | p.L41F | Q49B96 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CQ-5327-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
COX19 | SNV | Missense_Mutation | novel | c.35N>A | p.Phe12Tyr | p.F12Y | Q49B96 | protein_coding | deleterious(0.03) | possibly_damaging(0.686) | TCGA-DQ-5624-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
COX19 | SNV | Missense_Mutation | rs769215552 | c.229N>A | p.Gly77Arg | p.G77R | Q49B96 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-A4GF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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