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Gene: COL4A3BP |
Gene summary for COL4A3BP |
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Gene information | Species | Human | Gene symbol | COL4A3BP | Gene ID | 10087 |
Gene name | ceramide transporter 1 | |
Gene Alias | CERT | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y5P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10087 | COL4A3BP | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.83e-36 | -7.59e-01 | 0.0155 |
10087 | COL4A3BP | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.11e-22 | -7.59e-01 | -0.1808 |
10087 | COL4A3BP | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.32e-05 | -7.59e-01 | 0.0216 |
10087 | COL4A3BP | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.54e-17 | -7.59e-01 | -0.0811 |
10087 | COL4A3BP | HTA11_78_2000001011 | Human | Colorectum | AD | 1.90e-25 | -7.59e-01 | -0.1088 |
10087 | COL4A3BP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.82e-38 | -7.59e-01 | -0.1954 |
10087 | COL4A3BP | HTA11_411_2000001011 | Human | Colorectum | SER | 3.45e-03 | -7.59e-01 | -0.2602 |
10087 | COL4A3BP | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.39e-04 | -7.59e-01 | -0.2196 |
10087 | COL4A3BP | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.85e-17 | -7.59e-01 | -0.1207 |
10087 | COL4A3BP | HTA11_83_2000001011 | Human | Colorectum | SER | 3.59e-14 | -7.59e-01 | -0.1526 |
10087 | COL4A3BP | HTA11_696_2000001011 | Human | Colorectum | AD | 3.91e-47 | -7.59e-01 | -0.1464 |
10087 | COL4A3BP | HTA11_866_2000001011 | Human | Colorectum | AD | 1.94e-44 | -7.59e-01 | -0.1001 |
10087 | COL4A3BP | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.51e-29 | -7.59e-01 | -0.059 |
10087 | COL4A3BP | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.02e-07 | -7.59e-01 | -0.1706 |
10087 | COL4A3BP | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.46e-08 | -7.59e-01 | -0.2061 |
10087 | COL4A3BP | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.32e-05 | -7.59e-01 | -0.1462 |
10087 | COL4A3BP | HTA11_546_2000001011 | Human | Colorectum | AD | 2.32e-12 | -7.59e-01 | -0.0842 |
10087 | COL4A3BP | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.45e-03 | -7.59e-01 | -0.00410000000000005 |
10087 | COL4A3BP | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.90e-10 | -7.59e-01 | -0.0179 |
10087 | COL4A3BP | HTA11_866_3004761011 | Human | Colorectum | AD | 8.47e-32 | -7.59e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COL4A3BP | SNV | Missense_Mutation | c.861N>T | p.Glu287Asp | p.E287D | Q9Y5P4 | protein_coding | tolerated(0.08) | possibly_damaging(0.543) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
COL4A3BP | SNV | Missense_Mutation | c.1741G>A | p.Val581Ile | p.V581I | Q9Y5P4 | protein_coding | tolerated(0.17) | probably_damaging(0.993) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COL4A3BP | SNV | Missense_Mutation | c.638N>A | p.Arg213Gln | p.R213Q | Q9Y5P4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
COL4A3BP | SNV | Missense_Mutation | c.1516N>T | p.Met506Leu | p.M506L | Q9Y5P4 | protein_coding | tolerated(0.9) | benign(0.003) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
COL4A3BP | SNV | Missense_Mutation | c.1432C>T | p.Pro478Ser | p.P478S | Q9Y5P4 | protein_coding | tolerated(0.36) | benign(0.005) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
COL4A3BP | SNV | Missense_Mutation | c.1837N>A | p.Ala613Thr | p.A613T | Q9Y5P4 | protein_coding | deleterious(0.01) | benign(0.227) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
COL4A3BP | SNV | Missense_Mutation | c.1347G>T | p.Glu449Asp | p.E449D | Q9Y5P4 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COL4A3BP | SNV | Missense_Mutation | novel | c.935N>T | p.Ala312Val | p.A312V | Q9Y5P4 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
COL4A3BP | SNV | Missense_Mutation | c.1114N>A | p.Glu372Lys | p.E372K | Q9Y5P4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
COL4A3BP | SNV | Missense_Mutation | novel | c.1118N>T | p.Ala373Val | p.A373V | Q9Y5P4 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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