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Gene: CMKLR1 |
Gene summary for CMKLR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CMKLR1 | Gene ID | 1240 |
Gene name | chemerin chemokine-like receptor 1 | |
Gene Alias | CHEMERINR | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q99788 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1240 | CMKLR1 | ATC12 | Human | Thyroid | ATC | 1.19e-10 | 3.72e-01 | 0.34 |
1240 | CMKLR1 | ATC2 | Human | Thyroid | ATC | 7.49e-03 | 5.69e-01 | 0.34 |
1240 | CMKLR1 | ATC4 | Human | Thyroid | ATC | 6.15e-14 | 4.78e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ATC: Anaplastic thyroid cancer | |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109022 | Thyroid | ATC | regulation of DNA-binding transcription factor activity | 190/6293 | 440/18723 | 1.49e-05 | 1.39e-04 | 190 |
GO:005092123 | Thyroid | ATC | positive regulation of chemotaxis | 70/6293 | 141/18723 | 5.77e-05 | 4.43e-04 | 70 |
GO:004544423 | Thyroid | ATC | fat cell differentiation | 105/6293 | 229/18723 | 7.42e-05 | 5.62e-04 | 105 |
GO:003210324 | Thyroid | ATC | positive regulation of response to external stimulus | 178/6293 | 427/18723 | 2.61e-04 | 1.67e-03 | 178 |
GO:000268719 | Thyroid | ATC | positive regulation of leukocyte migration | 65/6293 | 135/18723 | 3.18e-04 | 1.99e-03 | 65 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:00509206 | Thyroid | ATC | regulation of chemotaxis | 99/6293 | 223/18723 | 4.91e-04 | 2.86e-03 | 99 |
GO:000269023 | Thyroid | ATC | positive regulation of leukocyte chemotaxis | 47/6293 | 94/18723 | 7.32e-04 | 4.11e-03 | 47 |
GO:199084521 | Thyroid | ATC | adaptive thermogenesis | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
GO:000268818 | Thyroid | ATC | regulation of leukocyte chemotaxis | 57/6293 | 122/18723 | 1.77e-03 | 8.71e-03 | 57 |
GO:000268519 | Thyroid | ATC | regulation of leukocyte migration | 90/6293 | 210/18723 | 3.11e-03 | 1.40e-02 | 90 |
GO:00508483 | Thyroid | ATC | regulation of calcium-mediated signaling | 36/6293 | 73/18723 | 3.91e-03 | 1.70e-02 | 36 |
GO:00434333 | Thyroid | ATC | negative regulation of DNA-binding transcription factor activity | 79/6293 | 185/18723 | 5.96e-03 | 2.40e-02 | 79 |
GO:01201625 | Thyroid | ATC | positive regulation of cold-induced thermogenesis | 45/6293 | 97/18723 | 5.97e-03 | 2.40e-02 | 45 |
GO:007167516 | Thyroid | ATC | regulation of mononuclear cell migration | 52/6293 | 115/18723 | 6.24e-03 | 2.50e-02 | 52 |
GO:004559822 | Thyroid | ATC | regulation of fat cell differentiation | 61/6293 | 139/18723 | 7.28e-03 | 2.86e-02 | 61 |
GO:004560023 | Thyroid | ATC | positive regulation of fat cell differentiation | 32/6293 | 66/18723 | 8.63e-03 | 3.28e-02 | 32 |
GO:000165912 | Thyroid | ATC | temperature homeostasis | 73/6293 | 174/18723 | 1.29e-02 | 4.51e-02 | 73 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Breast | DCIS |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Breast | IDC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Cervix | CC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | CRC | AD |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | CRC | SER |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | HNSCC | OSCC |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Liver | Healthy |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | Lung | AAH |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | ADJ |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | Cancer |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | Precancer |
RARRES2 | CMKLR1 | RARRES2_CMKLR1 | CHEMERIN | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMKLR1 | SNV | Missense_Mutation | c.283N>A | p.His95Asn | p.H95N | Q99788 | protein_coding | tolerated(0.74) | benign(0.003) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | rs750358962 | c.752G>A | p.Arg251His | p.R251H | Q99788 | protein_coding | tolerated(0.2) | possibly_damaging(0.786) | TCGA-AA-3534-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | novel | c.268G>A | p.Val90Ile | p.V90I | Q99788 | protein_coding | tolerated(0.68) | benign(0.021) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | novel | c.244N>A | p.Ala82Thr | p.A82T | Q99788 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | rs750358962 | c.752N>A | p.Arg251His | p.R251H | Q99788 | protein_coding | tolerated(0.2) | possibly_damaging(0.786) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CMKLR1 | SNV | Missense_Mutation | c.898N>A | p.Leu300Met | p.L300M | Q99788 | protein_coding | deleterious(0.01) | probably_damaging(0.943) | TCGA-CK-5914-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | rs370635582 | c.298N>A | p.Ala100Thr | p.A100T | Q99788 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-CL-5917-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CMKLR1 | SNV | Missense_Mutation | c.735N>G | p.Cys245Trp | p.C245W | Q99788 | protein_coding | tolerated(0.18) | possibly_damaging(0.72) | TCGA-DY-A1H8-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | c.734N>T | p.Cys245Phe | p.C245F | Q99788 | protein_coding | tolerated(0.78) | benign(0.007) | TCGA-DY-A1H8-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CMKLR1 | SNV | Missense_Mutation | c.1068N>A | p.Met356Ile | p.M356I | Q99788 | protein_coding | tolerated(0.22) | benign(0.147) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100364 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100428 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | CCX832 | |||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651892 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 354702257 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651571 | ||
1240 | CMKLR1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 354702254 |
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