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Gene: CLSTN1 |
Gene summary for CLSTN1 |
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Gene information | Species | Human | Gene symbol | CLSTN1 | Gene ID | 22883 |
Gene name | calsyntenin 1 | |
Gene Alias | ALC-ALPHA | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | O94985 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22883 | CLSTN1 | CA_HPV_1 | Human | Cervix | CC | 8.98e-07 | -2.49e-01 | 0.0264 |
22883 | CLSTN1 | CA_HPV_3 | Human | Cervix | CC | 2.72e-09 | 3.82e-01 | 0.0414 |
22883 | CLSTN1 | CCI_2 | Human | Cervix | CC | 6.13e-08 | 9.78e-01 | 0.5249 |
22883 | CLSTN1 | CCI_3 | Human | Cervix | CC | 2.85e-02 | 5.52e-01 | 0.516 |
22883 | CLSTN1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.16e-04 | -2.21e-01 | 0.0155 |
22883 | CLSTN1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.27e-04 | 5.16e-01 | -0.1808 |
22883 | CLSTN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.39e-05 | 4.48e-01 | -0.0811 |
22883 | CLSTN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.15e-27 | 8.98e-01 | -0.1954 |
22883 | CLSTN1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-04 | 1.15e+00 | -0.2602 |
22883 | CLSTN1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.81e-07 | 1.05e+00 | -0.2196 |
22883 | CLSTN1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.29e-02 | 4.21e-01 | -0.1526 |
22883 | CLSTN1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.68e-18 | 7.44e-01 | -0.1464 |
22883 | CLSTN1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.74e-05 | 4.82e-01 | -0.1001 |
22883 | CLSTN1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.73e-03 | 3.90e-01 | 0.281 |
22883 | CLSTN1 | A015-C-203 | Human | Colorectum | FAP | 6.68e-20 | -2.87e-01 | -0.1294 |
22883 | CLSTN1 | A014-C-040 | Human | Colorectum | FAP | 1.83e-02 | -4.81e-01 | -0.1184 |
22883 | CLSTN1 | A002-C-201 | Human | Colorectum | FAP | 6.33e-06 | -2.52e-01 | 0.0324 |
22883 | CLSTN1 | A001-C-108 | Human | Colorectum | FAP | 1.50e-08 | -2.02e-01 | -0.0272 |
22883 | CLSTN1 | A002-C-205 | Human | Colorectum | FAP | 3.82e-11 | -3.52e-01 | -0.1236 |
22883 | CLSTN1 | A015-C-006 | Human | Colorectum | FAP | 1.57e-08 | -4.30e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:19018886 | Cervix | CC | regulation of cell junction assembly | 42/2311 | 204/18723 | 5.50e-04 | 5.29e-03 | 42 |
GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
GO:00519622 | Cervix | CC | positive regulation of nervous system development | 48/2311 | 272/18723 | 6.60e-03 | 3.65e-02 | 48 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:0099072 | Colorectum | AD | regulation of postsynaptic membrane neurotransmitter receptor levels | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLSTN1 | SNV | Missense_Mutation | c.1670G>C | p.Cys557Ser | p.C557S | O94985 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CLSTN1 | SNV | Missense_Mutation | novel | c.1284N>G | p.Ile428Met | p.I428M | O94985 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CLSTN1 | SNV | Missense_Mutation | rs771283334 | c.2237N>G | p.Lys746Arg | p.K746R | O94985 | protein_coding | tolerated(0.77) | benign(0.006) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
CLSTN1 | SNV | Missense_Mutation | novel | c.1745N>C | p.His582Pro | p.H582P | O94985 | protein_coding | deleterious(0) | benign(0) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLSTN1 | SNV | Missense_Mutation | c.2327N>T | p.Arg776Leu | p.R776L | O94985 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLSTN1 | SNV | Missense_Mutation | rs375763180 | c.1466C>T | p.Pro489Leu | p.P489L | O94985 | protein_coding | tolerated(0.21) | probably_damaging(1) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLSTN1 | SNV | Missense_Mutation | novel | c.1540G>T | p.Asp514Tyr | p.D514Y | O94985 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLSTN1 | SNV | Missense_Mutation | novel | c.2735N>C | p.Val912Ala | p.V912A | O94985 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CLSTN1 | SNV | Missense_Mutation | rs769167202 | c.2413G>A | p.Glu805Lys | p.E805K | O94985 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLSTN1 | SNV | Missense_Mutation | novel | c.1789G>A | p.Glu597Lys | p.E597K | O94985 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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