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Gene: CLPTM1L |
Gene summary for CLPTM1L |
Gene summary. |
Gene information | Species | Human | Gene symbol | CLPTM1L | Gene ID | 81037 |
Gene name | CLPTM1 like | |
Gene Alias | CRR9 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q96KA5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81037 | CLPTM1L | HTA11_347_2000001011 | Human | Colorectum | AD | 7.01e-05 | 2.82e-01 | -0.1954 |
81037 | CLPTM1L | HTA11_696_2000001011 | Human | Colorectum | AD | 1.84e-07 | 3.35e-01 | -0.1464 |
81037 | CLPTM1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.57e-10 | 4.65e-01 | -0.059 |
81037 | CLPTM1L | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.39e-03 | 2.79e-01 | -0.0179 |
81037 | CLPTM1L | HTA11_866_3004761011 | Human | Colorectum | AD | 4.53e-04 | 3.03e-01 | 0.096 |
81037 | CLPTM1L | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.22e-04 | 3.57e-01 | 0.0674 |
81037 | CLPTM1L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.83e-08 | 4.08e-01 | 0.294 |
81037 | CLPTM1L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.43e-18 | 7.11e-01 | 0.3859 |
81037 | CLPTM1L | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.81e-04 | 5.18e-01 | 0.2585 |
81037 | CLPTM1L | A002-C-116 | Human | Colorectum | FAP | 9.45e-03 | -5.34e-02 | -0.0452 |
81037 | CLPTM1L | LZE2T | Human | Esophagus | ESCC | 5.92e-06 | 6.23e-01 | 0.082 |
81037 | CLPTM1L | LZE5T | Human | Esophagus | ESCC | 1.73e-05 | 3.20e-01 | 0.0514 |
81037 | CLPTM1L | LZE7T | Human | Esophagus | ESCC | 9.58e-03 | 2.67e-01 | 0.0667 |
81037 | CLPTM1L | LZE8T | Human | Esophagus | ESCC | 8.38e-03 | 1.32e-01 | 0.067 |
81037 | CLPTM1L | LZE20T | Human | Esophagus | ESCC | 1.31e-08 | 2.24e-01 | 0.0662 |
81037 | CLPTM1L | LZE22T | Human | Esophagus | ESCC | 1.44e-04 | 2.21e-01 | 0.068 |
81037 | CLPTM1L | LZE24T | Human | Esophagus | ESCC | 8.63e-09 | 1.10e-01 | 0.0596 |
81037 | CLPTM1L | P1T-E | Human | Esophagus | ESCC | 4.74e-09 | 2.21e-01 | 0.0875 |
81037 | CLPTM1L | P2T-E | Human | Esophagus | ESCC | 9.71e-11 | 1.52e-01 | 0.1177 |
81037 | CLPTM1L | P4T-E | Human | Esophagus | ESCC | 1.52e-16 | 5.15e-01 | 0.1323 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLPTM1L | SNV | Missense_Mutation | novel | c.1403N>T | p.Ala468Val | p.A468V | Q96KA5 | protein_coding | tolerated(0.06) | possibly_damaging(0.695) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | c.338N>A | p.Ala113Asp | p.A113D | Q96KA5 | protein_coding | tolerated(0.48) | benign(0.152) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLPTM1L | SNV | Missense_Mutation | novel | c.1501G>A | p.Val501Met | p.V501M | Q96KA5 | protein_coding | deleterious(0.01) | possibly_damaging(0.906) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | novel | c.1514N>A | p.Val505Asp | p.V505D | Q96KA5 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | novel | c.1240N>A | p.Gly414Arg | p.G414R | Q96KA5 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | c.1469N>T | p.Thr490Met | p.T490M | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
CLPTM1L | SNV | Missense_Mutation | novel | c.1529G>A | p.Arg510Gln | p.R510Q | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | rs867162034 | c.661N>T | p.Arg221Cys | p.R221C | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | novel | c.1568T>C | p.Phe523Ser | p.F523S | Q96KA5 | protein_coding | deleterious(0) | possibly_damaging(0.562) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | rs376982395 | c.742N>T | p.Arg248Trp | p.R248W | Q96KA5 | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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