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Gene: CLK1 |
Gene summary for CLK1 |
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Gene information | Species | Human | Gene symbol | CLK1 | Gene ID | 1195 |
Gene name | CDC like kinase 1 | |
Gene Alias | CLK | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P49759 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1195 | CLK1 | GSM4909277 | Human | Breast | Precancer | 5.06e-06 | 7.47e-01 | 0.0177 |
1195 | CLK1 | GSM4909280 | Human | Breast | Precancer | 8.53e-04 | 4.80e-01 | 0.0305 |
1195 | CLK1 | GSM4909282 | Human | Breast | IDC | 3.40e-08 | -4.20e-01 | -0.0288 |
1195 | CLK1 | GSM4909285 | Human | Breast | IDC | 3.35e-09 | -3.99e-01 | 0.21 |
1195 | CLK1 | GSM4909286 | Human | Breast | IDC | 2.43e-07 | -3.58e-01 | 0.1081 |
1195 | CLK1 | GSM4909290 | Human | Breast | IDC | 1.55e-02 | -3.50e-01 | 0.2096 |
1195 | CLK1 | GSM4909294 | Human | Breast | IDC | 2.18e-09 | -4.28e-01 | 0.2022 |
1195 | CLK1 | GSM4909296 | Human | Breast | IDC | 7.18e-13 | -4.05e-01 | 0.1524 |
1195 | CLK1 | GSM4909297 | Human | Breast | IDC | 5.42e-09 | -1.45e-01 | 0.1517 |
1195 | CLK1 | GSM4909298 | Human | Breast | IDC | 3.95e-04 | -2.69e-01 | 0.1551 |
1195 | CLK1 | GSM4909302 | Human | Breast | IDC | 6.63e-04 | -3.58e-01 | 0.1545 |
1195 | CLK1 | GSM4909306 | Human | Breast | IDC | 2.76e-02 | -3.04e-01 | 0.1564 |
1195 | CLK1 | GSM4909308 | Human | Breast | IDC | 2.02e-02 | -2.97e-01 | 0.158 |
1195 | CLK1 | GSM4909311 | Human | Breast | IDC | 1.41e-27 | -5.12e-01 | 0.1534 |
1195 | CLK1 | GSM4909312 | Human | Breast | IDC | 7.69e-09 | -3.47e-01 | 0.1552 |
1195 | CLK1 | GSM4909319 | Human | Breast | IDC | 6.09e-29 | -5.20e-01 | 0.1563 |
1195 | CLK1 | GSM4909320 | Human | Breast | IDC | 9.53e-07 | -5.39e-01 | 0.1575 |
1195 | CLK1 | GSM4909321 | Human | Breast | IDC | 3.89e-15 | -4.40e-01 | 0.1559 |
1195 | CLK1 | ctrl6 | Human | Breast | Precancer | 9.59e-10 | 5.83e-01 | -0.0061 |
1195 | CLK1 | brca1 | Human | Breast | Precancer | 1.21e-06 | -3.69e-01 | -0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:004348424 | Breast | DCIS | regulation of RNA splicing | 36/1390 | 148/18723 | 1.40e-10 | 1.69e-08 | 36 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:001810710 | Esophagus | ESCC | peptidyl-threonine phosphorylation | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:001821010 | Esophagus | ESCC | peptidyl-threonine modification | 70/8552 | 125/18723 | 1.29e-02 | 4.25e-02 | 70 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:004348412 | Liver | Cirrhotic | regulation of RNA splicing | 85/4634 | 148/18723 | 2.03e-17 | 2.83e-15 | 85 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513422 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0513432 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0513427 | Esophagus | HGIN | Legionellosis | 18/1383 | 57/8465 | 3.20e-03 | 2.54e-02 | 2.02e-02 | 18 |
hsa05134112 | Esophagus | HGIN | Legionellosis | 18/1383 | 57/8465 | 3.20e-03 | 2.54e-02 | 2.02e-02 | 18 |
hsa0513428 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0513436 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa0513412 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa0513413 | Liver | Cirrhotic | Legionellosis | 28/2530 | 57/8465 | 1.71e-03 | 8.01e-03 | 4.94e-03 | 28 |
hsa0513425 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa05134111 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa0513426 | Oral cavity | LP | Legionellosis | 33/2418 | 57/8465 | 3.29e-06 | 3.23e-05 | 2.08e-05 | 33 |
hsa0513435 | Oral cavity | LP | Legionellosis | 33/2418 | 57/8465 | 3.29e-06 | 3.23e-05 | 2.08e-05 | 33 |
hsa0513443 | Oral cavity | EOLP | Legionellosis | 18/1218 | 57/8465 | 7.27e-04 | 2.73e-03 | 1.61e-03 | 18 |
hsa0513453 | Oral cavity | EOLP | Legionellosis | 18/1218 | 57/8465 | 7.27e-04 | 2.73e-03 | 1.61e-03 | 18 |
hsa0513461 | Oral cavity | NEOLP | Legionellosis | 15/1112 | 57/8465 | 5.58e-03 | 2.17e-02 | 1.36e-02 | 15 |
hsa0513471 | Oral cavity | NEOLP | Legionellosis | 15/1112 | 57/8465 | 5.58e-03 | 2.17e-02 | 1.36e-02 | 15 |
hsa0513420 | Prostate | BPH | Legionellosis | 22/1718 | 57/8465 | 1.10e-03 | 4.99e-03 | 3.09e-03 | 22 |
hsa05134110 | Prostate | BPH | Legionellosis | 22/1718 | 57/8465 | 1.10e-03 | 4.99e-03 | 3.09e-03 | 22 |
hsa0513424 | Prostate | Tumor | Legionellosis | 22/1791 | 57/8465 | 1.95e-03 | 7.98e-03 | 4.95e-03 | 22 |
hsa0513434 | Prostate | Tumor | Legionellosis | 22/1791 | 57/8465 | 1.95e-03 | 7.98e-03 | 4.95e-03 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLK1 | SNV | Missense_Mutation | rs753962479 | c.502C>T | p.Arg168Cys | p.R168C | P49759 | protein_coding | tolerated(0.07) | benign(0.116) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLK1 | SNV | Missense_Mutation | c.356N>T | p.Arg119Ile | p.R119I | P49759 | protein_coding | deleterious(0.02) | benign(0.393) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CLK1 | SNV | Missense_Mutation | novel | c.1013N>G | p.Phe338Cys | p.F338C | P49759 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CLK1 | SNV | Missense_Mutation | c.1520N>T | p.Arg507Ile | p.R507I | P49759 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CLK1 | SNV | Missense_Mutation | c.1462N>A | p.Glu488Lys | p.E488K | P49759 | protein_coding | deleterious(0.04) | possibly_damaging(0.742) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLK1 | SNV | Missense_Mutation | c.790N>G | p.Phe264Val | p.F264V | P49759 | protein_coding | tolerated(0.07) | possibly_damaging(0.518) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLK1 | SNV | Missense_Mutation | rs140005351 | c.146C>T | p.Thr49Ile | p.T49I | P49759 | protein_coding | tolerated_low_confidence(0.09) | benign(0.136) | TCGA-F5-6702-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | PD |
CLK1 | insertion | Frame_Shift_Ins | novel | c.401_402insAAACGTTCATACC | p.Asp134GlufsTer7 | p.D134Efs*7 | P49759 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLK1 | SNV | Missense_Mutation | c.944N>A | p.Cys315Tyr | p.C315Y | P49759 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLK1 | SNV | Missense_Mutation | rs200483830 | c.326N>G | p.Tyr109Cys | p.Y109C | P49759 | protein_coding | tolerated(0.14) | possibly_damaging(0.502) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565795 | ||
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565842 | ||
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | HARMINE | HARMINE | 22998443 | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565735 | ||
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565841 | ||
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | LEUCETTAMINE B | LEUCETTAMINE B | 22998443 | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | NU-2058 | CHEMBL269881 | ||
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | TG003 |
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