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Gene: CLDND1 |
Gene summary for CLDND1 |
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Gene information | Species | Human | Gene symbol | CLDND1 | Gene ID | 56650 |
Gene name | claudin domain containing 1 | |
Gene Alias | C3orf4 | |
Cytomap | 3q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NY35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56650 | CLDND1 | Tumor | Human | Cervix | CC | 1.96e-08 | 4.18e-01 | 0.1241 |
56650 | CLDND1 | sample3 | Human | Cervix | CC | 2.88e-24 | 5.81e-01 | 0.1387 |
56650 | CLDND1 | L1 | Human | Cervix | CC | 6.80e-04 | 3.35e-01 | 0.0802 |
56650 | CLDND1 | T1 | Human | Cervix | CC | 8.54e-05 | 2.87e-01 | 0.0918 |
56650 | CLDND1 | T3 | Human | Cervix | CC | 3.59e-19 | 5.73e-01 | 0.1389 |
56650 | CLDND1 | LZE4T | Human | Esophagus | ESCC | 7.33e-25 | 9.39e-01 | 0.0811 |
56650 | CLDND1 | LZE7T | Human | Esophagus | ESCC | 3.56e-09 | 9.97e-01 | 0.0667 |
56650 | CLDND1 | LZE8T | Human | Esophagus | ESCC | 2.95e-18 | 8.71e-01 | 0.067 |
56650 | CLDND1 | LZE20T | Human | Esophagus | ESCC | 3.73e-04 | 2.56e-01 | 0.0662 |
56650 | CLDND1 | LZE22T | Human | Esophagus | ESCC | 1.11e-02 | 4.77e-01 | 0.068 |
56650 | CLDND1 | LZE24T | Human | Esophagus | ESCC | 2.04e-28 | 1.07e+00 | 0.0596 |
56650 | CLDND1 | LZE6T | Human | Esophagus | ESCC | 7.72e-08 | 7.02e-01 | 0.0845 |
56650 | CLDND1 | P1T-E | Human | Esophagus | ESCC | 4.97e-13 | 5.89e-01 | 0.0875 |
56650 | CLDND1 | P2T-E | Human | Esophagus | ESCC | 6.36e-31 | 4.43e-01 | 0.1177 |
56650 | CLDND1 | P4T-E | Human | Esophagus | ESCC | 2.40e-30 | 7.61e-01 | 0.1323 |
56650 | CLDND1 | P5T-E | Human | Esophagus | ESCC | 4.29e-69 | 1.56e+00 | 0.1327 |
56650 | CLDND1 | P8T-E | Human | Esophagus | ESCC | 5.59e-56 | 1.12e+00 | 0.0889 |
56650 | CLDND1 | P9T-E | Human | Esophagus | ESCC | 3.70e-77 | 2.95e+00 | 0.1131 |
56650 | CLDND1 | P10T-E | Human | Esophagus | ESCC | 2.84e-64 | 1.35e+00 | 0.116 |
56650 | CLDND1 | P11T-E | Human | Esophagus | ESCC | 2.43e-18 | 5.60e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLDND1 | SNV | Missense_Mutation | novel | c.754N>A | p.Ala252Thr | p.A252T | protein_coding | tolerated(0.23) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | novel | c.172N>C | p.Tyr58His | p.Y58H | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | rs866129045 | c.590G>A | p.Gly197Asp | p.G197D | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | rs373607092 | c.482N>A | p.Arg161His | p.R161H | protein_coding | deleterious(0.02) | possibly_damaging(0.481) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | novel | c.566G>T | p.Ser189Ile | p.S189I | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
CLDND1 | SNV | Missense_Mutation | c.176N>A | p.Arg59Gln | p.R59Q | protein_coding | tolerated(0.16) | benign(0.036) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLDND1 | SNV | Missense_Mutation | novel | c.344G>A | p.Ser115Asn | p.S115N | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | c.682C>A | p.Pro228Thr | p.P228T | protein_coding | tolerated(0.08) | possibly_damaging(0.657) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLDND1 | SNV | Missense_Mutation | rs764394607 | c.791G>A | p.Arg264Gln | p.R264Q | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLDND1 | SNV | Missense_Mutation | c.176G>A | p.Arg59Gln | p.R59Q | protein_coding | tolerated(0.16) | benign(0.036) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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