![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLDN12 |
Gene summary for CLDN12 |
![]() |
Gene information | Species | Human | Gene symbol | CLDN12 | Gene ID | 9069 |
Gene name | claudin 12 | |
Gene Alias | CLDN12 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | B2R687 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9069 | CLDN12 | LZE20T | Human | Esophagus | ESCC | 7.24e-03 | 1.47e-02 | 0.0662 |
9069 | CLDN12 | LZE24T | Human | Esophagus | ESCC | 8.08e-05 | 1.30e-01 | 0.0596 |
9069 | CLDN12 | P2T-E | Human | Esophagus | ESCC | 1.39e-11 | 1.45e-01 | 0.1177 |
9069 | CLDN12 | P4T-E | Human | Esophagus | ESCC | 8.00e-11 | 2.30e-01 | 0.1323 |
9069 | CLDN12 | P5T-E | Human | Esophagus | ESCC | 1.41e-07 | 1.73e-02 | 0.1327 |
9069 | CLDN12 | P8T-E | Human | Esophagus | ESCC | 1.25e-23 | 2.40e-01 | 0.0889 |
9069 | CLDN12 | P9T-E | Human | Esophagus | ESCC | 8.05e-12 | 1.12e-01 | 0.1131 |
9069 | CLDN12 | P10T-E | Human | Esophagus | ESCC | 3.97e-10 | 1.24e-01 | 0.116 |
9069 | CLDN12 | P11T-E | Human | Esophagus | ESCC | 4.72e-05 | 2.73e-01 | 0.1426 |
9069 | CLDN12 | P12T-E | Human | Esophagus | ESCC | 1.18e-09 | 2.60e-01 | 0.1122 |
9069 | CLDN12 | P15T-E | Human | Esophagus | ESCC | 8.84e-12 | 2.55e-01 | 0.1149 |
9069 | CLDN12 | P16T-E | Human | Esophagus | ESCC | 2.79e-72 | 1.30e+00 | 0.1153 |
9069 | CLDN12 | P19T-E | Human | Esophagus | ESCC | 4.92e-04 | 2.89e-01 | 0.1662 |
9069 | CLDN12 | P20T-E | Human | Esophagus | ESCC | 1.78e-10 | 1.69e-01 | 0.1124 |
9069 | CLDN12 | P21T-E | Human | Esophagus | ESCC | 2.40e-19 | 1.92e-01 | 0.1617 |
9069 | CLDN12 | P22T-E | Human | Esophagus | ESCC | 3.00e-10 | 3.28e-02 | 0.1236 |
9069 | CLDN12 | P23T-E | Human | Esophagus | ESCC | 1.46e-18 | 4.61e-01 | 0.108 |
9069 | CLDN12 | P24T-E | Human | Esophagus | ESCC | 4.25e-11 | 4.66e-02 | 0.1287 |
9069 | CLDN12 | P26T-E | Human | Esophagus | ESCC | 7.78e-14 | 2.06e-01 | 0.1276 |
9069 | CLDN12 | P27T-E | Human | Esophagus | ESCC | 1.63e-08 | 7.11e-02 | 0.1055 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003563310 | Esophagus | ESCC | maintenance of blood-brain barrier | 24/8552 | 35/18723 | 5.25e-03 | 1.97e-02 | 24 |
GO:003563315 | Prostate | Tumor | maintenance of blood-brain barrier | 17/3246 | 35/18723 | 2.09e-05 | 2.71e-04 | 17 |
GO:000189416 | Prostate | Tumor | tissue homeostasis | 65/3246 | 268/18723 | 2.39e-03 | 1.35e-02 | 65 |
GO:006024915 | Prostate | Tumor | anatomical structure homeostasis | 74/3246 | 314/18723 | 2.82e-03 | 1.54e-02 | 74 |
GO:003563319 | Thyroid | PTC | maintenance of blood-brain barrier | 19/5968 | 35/18723 | 4.94e-03 | 2.29e-02 | 19 |
GO:003563322 | Thyroid | ATC | maintenance of blood-brain barrier | 22/6293 | 35/18723 | 3.74e-04 | 2.28e-03 | 22 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLDN12 | SNV | Missense_Mutation | c.481N>A | p.Leu161Met | p.L161M | P56749 | protein_coding | tolerated(0.37) | benign(0.056) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLDN12 | SNV | Missense_Mutation | rs767199576 | c.602C>A | p.Ser201Tyr | p.S201Y | P56749 | protein_coding | deleterious(0.02) | benign(0.264) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLDN12 | SNV | Missense_Mutation | rs777274351 | c.503T>C | p.Val168Ala | p.V168A | P56749 | protein_coding | tolerated(0.37) | benign(0.107) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CLDN12 | SNV | Missense_Mutation | rs761164855 | c.22N>A | p.Ala8Thr | p.A8T | P56749 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CLDN12 | SNV | Missense_Mutation | novel | c.652N>T | p.His218Tyr | p.H218Y | P56749 | protein_coding | tolerated(0.95) | possibly_damaging(0.549) | TCGA-A5-A7WK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
CLDN12 | SNV | Missense_Mutation | c.685C>A | p.Arg229Ser | p.R229S | P56749 | protein_coding | deleterious(0.03) | possibly_damaging(0.7) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | |
CLDN12 | SNV | Missense_Mutation | novel | c.130A>T | p.Asn44Tyr | p.N44Y | P56749 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CLDN12 | SNV | Missense_Mutation | novel | c.298N>A | p.Ala100Thr | p.A100T | P56749 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLDN12 | SNV | Missense_Mutation | c.586N>C | p.Tyr196His | p.Y196H | P56749 | protein_coding | tolerated(0.11) | probably_damaging(0.996) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLDN12 | SNV | Missense_Mutation | rs767199576 | c.602N>A | p.Ser201Tyr | p.S201Y | P56749 | protein_coding | deleterious(0.02) | benign(0.264) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |