![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLCA2 |
Gene summary for CLCA2 |
![]() |
Gene information | Species | Human | Gene symbol | CLCA2 | Gene ID | 9635 |
Gene name | chloride channel accessory 2 | |
Gene Alias | CACC | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UQC9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9635 | CLCA2 | CA_HPV_1 | Human | Cervix | CC | 4.77e-06 | -2.41e-01 | 0.0264 |
9635 | CLCA2 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 1.84e-04 | -2.59e-01 | 0.0116 |
9635 | CLCA2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.84e-03 | -2.30e-01 | 0.0208 |
9635 | CLCA2 | Tumor | Human | Cervix | CC | 1.38e-43 | 8.95e-01 | 0.1241 |
9635 | CLCA2 | sample3 | Human | Cervix | CC | 1.61e-45 | 8.28e-01 | 0.1387 |
9635 | CLCA2 | H2 | Human | Cervix | HSIL_HPV | 2.46e-04 | -2.41e-01 | 0.0632 |
9635 | CLCA2 | T1 | Human | Cervix | CC | 3.99e-08 | -2.68e-01 | 0.0918 |
9635 | CLCA2 | T3 | Human | Cervix | CC | 2.79e-44 | 8.11e-01 | 0.1389 |
9635 | CLCA2 | LZE4T | Human | Esophagus | ESCC | 2.36e-08 | 5.50e-01 | 0.0811 |
9635 | CLCA2 | LZE7T | Human | Esophagus | ESCC | 7.18e-05 | 1.53e+00 | 0.0667 |
9635 | CLCA2 | P1T-E | Human | Esophagus | ESCC | 1.87e-02 | 7.90e-01 | 0.0875 |
9635 | CLCA2 | P4T-E | Human | Esophagus | ESCC | 1.26e-04 | 2.69e-01 | 0.1323 |
9635 | CLCA2 | P5T-E | Human | Esophagus | ESCC | 3.67e-10 | 4.04e-01 | 0.1327 |
9635 | CLCA2 | P8T-E | Human | Esophagus | ESCC | 1.60e-03 | -2.84e-01 | 0.0889 |
9635 | CLCA2 | P9T-E | Human | Esophagus | ESCC | 4.27e-15 | 5.76e-01 | 0.1131 |
9635 | CLCA2 | P10T-E | Human | Esophagus | ESCC | 9.32e-17 | 5.77e-01 | 0.116 |
9635 | CLCA2 | P11T-E | Human | Esophagus | ESCC | 4.64e-10 | 1.54e+00 | 0.1426 |
9635 | CLCA2 | P12T-E | Human | Esophagus | ESCC | 4.30e-37 | 1.82e+00 | 0.1122 |
9635 | CLCA2 | P15T-E | Human | Esophagus | ESCC | 1.51e-14 | 7.79e-01 | 0.1149 |
9635 | CLCA2 | P16T-E | Human | Esophagus | ESCC | 6.61e-09 | -4.83e-02 | 0.1153 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCA2 | SNV | Missense_Mutation | novel | c.2736N>C | p.Leu912Phe | p.L912F | Q9UQC9 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLCA2 | insertion | Nonsense_Mutation | novel | c.1945_1946insATGGGTATTGTTCAGGGT | p.Gly649delinsAspGlyTyrCysSerGlyTer | p.G649delinsDGYCSG* | Q9UQC9 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
CLCA2 | SNV | Missense_Mutation | novel | c.784N>A | p.Ala262Thr | p.A262T | Q9UQC9 | protein_coding | deleterious(0) | possibly_damaging(0.666) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCA2 | SNV | Missense_Mutation | rs781089415 | c.2651N>T | p.Ala884Val | p.A884V | Q9UQC9 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLCA2 | SNV | Missense_Mutation | c.857N>G | p.His286Arg | p.H286R | Q9UQC9 | protein_coding | tolerated(0.56) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
CLCA2 | SNV | Missense_Mutation | c.2615N>C | p.Asn872Thr | p.N872T | Q9UQC9 | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CLCA2 | SNV | Missense_Mutation | c.2181N>T | p.Arg727Ser | p.R727S | Q9UQC9 | protein_coding | deleterious(0.02) | benign(0.162) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CLCA2 | SNV | Missense_Mutation | c.391G>T | p.Gly131Trp | p.G131W | Q9UQC9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLCA2 | SNV | Missense_Mutation | c.526N>A | p.Glu176Lys | p.E176K | Q9UQC9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
CLCA2 | SNV | Missense_Mutation | novel | c.2709G>T | p.Leu903Phe | p.L903F | Q9UQC9 | protein_coding | tolerated(0.51) | benign(0.361) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |