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Gene: CIAO1 |
Gene summary for CIAO1 |
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Gene information | Species | Human | Gene symbol | CIAO1 | Gene ID | 9391 |
Gene name | cytosolic iron-sulfur assembly component 1 | |
Gene Alias | CIA1 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O76071 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9391 | CIAO1 | LZE2T | Human | Esophagus | ESCC | 4.08e-05 | 8.64e-01 | 0.082 |
9391 | CIAO1 | LZE4T | Human | Esophagus | ESCC | 1.36e-23 | 7.16e-01 | 0.0811 |
9391 | CIAO1 | LZE7T | Human | Esophagus | ESCC | 5.04e-21 | 9.19e-01 | 0.0667 |
9391 | CIAO1 | LZE8T | Human | Esophagus | ESCC | 2.01e-06 | 3.42e-01 | 0.067 |
9391 | CIAO1 | LZE20T | Human | Esophagus | ESCC | 6.57e-07 | 2.79e-01 | 0.0662 |
9391 | CIAO1 | LZE22T | Human | Esophagus | ESCC | 1.06e-07 | 6.96e-01 | 0.068 |
9391 | CIAO1 | LZE24T | Human | Esophagus | ESCC | 3.07e-19 | 6.59e-01 | 0.0596 |
9391 | CIAO1 | LZE21T | Human | Esophagus | ESCC | 1.19e-06 | 6.08e-01 | 0.0655 |
9391 | CIAO1 | LZE6T | Human | Esophagus | ESCC | 8.15e-12 | 5.37e-01 | 0.0845 |
9391 | CIAO1 | P1T-E | Human | Esophagus | ESCC | 3.33e-17 | 7.85e-01 | 0.0875 |
9391 | CIAO1 | P2T-E | Human | Esophagus | ESCC | 1.62e-47 | 8.56e-01 | 0.1177 |
9391 | CIAO1 | P4T-E | Human | Esophagus | ESCC | 6.24e-46 | 1.02e+00 | 0.1323 |
9391 | CIAO1 | P5T-E | Human | Esophagus | ESCC | 5.58e-36 | 7.97e-01 | 0.1327 |
9391 | CIAO1 | P8T-E | Human | Esophagus | ESCC | 1.65e-31 | 5.29e-01 | 0.0889 |
9391 | CIAO1 | P9T-E | Human | Esophagus | ESCC | 3.96e-22 | 4.66e-01 | 0.1131 |
9391 | CIAO1 | P10T-E | Human | Esophagus | ESCC | 4.56e-47 | 9.65e-01 | 0.116 |
9391 | CIAO1 | P11T-E | Human | Esophagus | ESCC | 2.56e-26 | 9.98e-01 | 0.1426 |
9391 | CIAO1 | P12T-E | Human | Esophagus | ESCC | 1.17e-50 | 1.00e+00 | 0.1122 |
9391 | CIAO1 | P15T-E | Human | Esophagus | ESCC | 1.13e-46 | 8.63e-01 | 0.1149 |
9391 | CIAO1 | P16T-E | Human | Esophagus | ESCC | 2.29e-38 | 7.07e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:0007059 | Liver | HCC | chromosome segregation | 197/7958 | 346/18723 | 3.57e-08 | 7.87e-07 | 197 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:0031163 | Liver | HCC | metallo-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00162262 | Oral cavity | OSCC | iron-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00311632 | Oral cavity | OSCC | metallo-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:0097428 | Oral cavity | OSCC | protein maturation by iron-sulfur cluster transfer | 11/7305 | 16/18723 | 1.56e-02 | 4.99e-02 | 11 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:00070591 | Oral cavity | LP | chromosome segregation | 117/4623 | 346/18723 | 7.61e-05 | 9.91e-04 | 117 |
GO:00162261 | Oral cavity | LP | iron-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CIAO1 | SNV | Missense_Mutation | novel | c.985N>T | p.Ala329Ser | p.A329S | O76071 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | rs751470231 | c.436N>T | p.Leu146Phe | p.L146F | O76071 | protein_coding | deleterious(0.01) | possibly_damaging(0.738) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | rs200912319 | c.772N>G | p.Ile258Val | p.I258V | O76071 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | rs776406200 | c.706G>A | p.Gly236Ser | p.G236S | O76071 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | c.694N>A | p.Val232Met | p.V232M | O76071 | protein_coding | tolerated(0.08) | benign(0.333) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CIAO1 | SNV | Missense_Mutation | rs772533972 | c.304N>A | p.Glu102Lys | p.E102K | O76071 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | novel | c.463N>T | p.His155Tyr | p.H155Y | O76071 | protein_coding | tolerated(1) | probably_damaging(0.911) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | rs191488251 | c.920N>G | p.Asn307Ser | p.N307S | O76071 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CIAO1 | SNV | Missense_Mutation | c.194N>T | p.Arg65Leu | p.R65L | O76071 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CIAO1 | SNV | Missense_Mutation | c.535N>A | p.Glu179Lys | p.E179K | O76071 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-55-7727-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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