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Gene: CEP57 |
Gene summary for CEP57 |
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Gene information | Species | Human | Gene symbol | CEP57 | Gene ID | 9702 |
Gene name | centrosomal protein 57 | |
Gene Alias | MVA2 | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86XR8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9702 | CEP57 | LZE2T | Human | Esophagus | ESCC | 5.26e-05 | 8.69e-01 | 0.082 |
9702 | CEP57 | LZE4T | Human | Esophagus | ESCC | 1.22e-10 | 3.19e-01 | 0.0811 |
9702 | CEP57 | LZE5T | Human | Esophagus | ESCC | 6.99e-03 | 2.66e-01 | 0.0514 |
9702 | CEP57 | LZE7T | Human | Esophagus | ESCC | 3.47e-13 | 7.02e-01 | 0.0667 |
9702 | CEP57 | LZE8T | Human | Esophagus | ESCC | 8.85e-04 | 2.30e-01 | 0.067 |
9702 | CEP57 | LZE20T | Human | Esophagus | ESCC | 8.88e-08 | 2.45e-01 | 0.0662 |
9702 | CEP57 | LZE24T | Human | Esophagus | ESCC | 2.75e-28 | 8.27e-01 | 0.0596 |
9702 | CEP57 | LZE21T | Human | Esophagus | ESCC | 6.28e-07 | 3.12e-01 | 0.0655 |
9702 | CEP57 | LZE6T | Human | Esophagus | ESCC | 1.45e-02 | 2.72e-01 | 0.0845 |
9702 | CEP57 | P1T-E | Human | Esophagus | ESCC | 4.57e-08 | 5.87e-01 | 0.0875 |
9702 | CEP57 | P2T-E | Human | Esophagus | ESCC | 5.68e-38 | 6.74e-01 | 0.1177 |
9702 | CEP57 | P4T-E | Human | Esophagus | ESCC | 4.38e-51 | 1.22e+00 | 0.1323 |
9702 | CEP57 | P5T-E | Human | Esophagus | ESCC | 1.32e-17 | 4.34e-01 | 0.1327 |
9702 | CEP57 | P8T-E | Human | Esophagus | ESCC | 7.21e-12 | 2.76e-01 | 0.0889 |
9702 | CEP57 | P9T-E | Human | Esophagus | ESCC | 5.70e-17 | 4.09e-01 | 0.1131 |
9702 | CEP57 | P10T-E | Human | Esophagus | ESCC | 9.50e-36 | 7.25e-01 | 0.116 |
9702 | CEP57 | P11T-E | Human | Esophagus | ESCC | 1.86e-11 | 7.21e-01 | 0.1426 |
9702 | CEP57 | P12T-E | Human | Esophagus | ESCC | 9.69e-52 | 9.50e-01 | 0.1122 |
9702 | CEP57 | P15T-E | Human | Esophagus | ESCC | 7.81e-13 | 3.70e-01 | 0.1149 |
9702 | CEP57 | P16T-E | Human | Esophagus | ESCC | 6.72e-54 | 9.70e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
GO:00512591 | Oral cavity | LP | protein complex oligomerization | 85/4623 | 238/18723 | 8.81e-05 | 1.11e-03 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP57 | SNV | Missense_Mutation | novel | c.5C>T | p.Ala2Val | p.A2V | Q86XR8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.97) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CEP57 | SNV | Missense_Mutation | c.1480N>G | p.Ser494Gly | p.S494G | Q86XR8 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP57 | SNV | Missense_Mutation | novel | c.1432N>A | p.Leu478Ile | p.L478I | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CEP57 | SNV | Missense_Mutation | novel | c.571C>A | p.Leu191Ile | p.L191I | Q86XR8 | protein_coding | tolerated(0.24) | benign(0.018) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CEP57 | deletion | Frame_Shift_Del | rs765532194 | c.778delN | p.Lys262ArgfsTer31 | p.K262Rfs*31 | Q86XR8 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CEP57 | deletion | Frame_Shift_Del | c.1409_1418delNNNNNNNNNN | p.Pro470GlnfsTer9 | p.P470Qfs*9 | Q86XR8 | protein_coding | TCGA-NH-A8F7-06 | Colorectum | NA | NA | NA | NA | NA | NA | NA | |||
CEP57 | deletion | Frame_Shift_Del | rs765532194 | c.778delN | p.Lys262ArgfsTer31 | p.K262Rfs*31 | Q86XR8 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | ||
CEP57 | SNV | Missense_Mutation | novel | c.958N>T | p.Ala320Ser | p.A320S | Q86XR8 | protein_coding | tolerated(0.07) | benign(0.054) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CEP57 | SNV | Missense_Mutation | c.1293N>T | p.Glu431Asp | p.E431D | Q86XR8 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CEP57 | SNV | Missense_Mutation | novel | c.773N>T | p.Arg258Ile | p.R258I | Q86XR8 | protein_coding | deleterious(0.04) | benign(0.276) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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