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Gene: CEMIP |
Gene summary for CEMIP |
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Gene information | Species | Human | Gene symbol | CEMIP | Gene ID | 57214 |
Gene name | cell migration inducing hyaluronidase 1 | |
Gene Alias | CCSP1 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q8WUJ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57214 | CEMIP | CCI_1 | Human | Cervix | CC | 1.66e-04 | 5.97e-01 | 0.528 |
57214 | CEMIP | CCI_2 | Human | Cervix | CC | 2.71e-03 | 4.86e-01 | 0.5249 |
57214 | CEMIP | CCI_3 | Human | Cervix | CC | 2.81e-03 | 2.71e-01 | 0.516 |
57214 | CEMIP | CCII_1 | Human | Cervix | CC | 2.68e-07 | 3.29e-01 | 0.3249 |
57214 | CEMIP | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.76e-16 | 6.60e-01 | 0.0155 |
57214 | CEMIP | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.57e-04 | 7.14e-01 | 0.0216 |
57214 | CEMIP | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.54e-37 | 1.66e+00 | -0.0811 |
57214 | CEMIP | HTA11_78_2000001011 | Human | Colorectum | AD | 7.83e-07 | 8.31e-01 | -0.1088 |
57214 | CEMIP | HTA11_696_2000001011 | Human | Colorectum | AD | 5.31e-03 | 3.65e-01 | -0.1464 |
57214 | CEMIP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.13e-24 | 1.46e+00 | -0.059 |
57214 | CEMIP | HTA11_866_3004761011 | Human | Colorectum | AD | 1.55e-11 | 6.02e-01 | 0.096 |
57214 | CEMIP | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.24e-21 | 1.49e+00 | 0.0338 |
57214 | CEMIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.35e-33 | 1.16e+00 | 0.0674 |
57214 | CEMIP | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.44e-03 | 6.26e-01 | 0.0112 |
57214 | CEMIP | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.01e-27 | 1.34e+00 | 0.0588 |
57214 | CEMIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.28e-34 | 7.97e-01 | 0.294 |
57214 | CEMIP | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.08e-06 | 1.47e+00 | 0.3487 |
57214 | CEMIP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.79e-10 | 7.02e-01 | 0.281 |
57214 | CEMIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.30e-42 | 1.24e+00 | 0.3859 |
57214 | CEMIP | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.22e-02 | 4.32e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:000660510 | Cervix | CC | protein targeting | 68/2311 | 314/18723 | 2.17e-06 | 6.55e-05 | 68 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:00903167 | Cervix | CC | positive regulation of intracellular protein transport | 41/2311 | 160/18723 | 3.24e-06 | 8.80e-05 | 41 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00331579 | Cervix | CC | regulation of intracellular protein transport | 52/2311 | 229/18723 | 8.16e-06 | 1.88e-04 | 52 |
GO:00719025 | Cervix | CC | positive regulation of protein serine/threonine kinase activity | 46/2311 | 200/18723 | 1.87e-05 | 3.47e-04 | 46 |
GO:19054778 | Cervix | CC | positive regulation of protein localization to membrane | 29/2311 | 106/18723 | 2.29e-05 | 4.01e-04 | 29 |
GO:00323889 | Cervix | CC | positive regulation of intracellular transport | 46/2311 | 202/18723 | 2.45e-05 | 4.24e-04 | 46 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:19054758 | Cervix | CC | regulation of protein localization to membrane | 36/2311 | 175/18723 | 1.33e-03 | 1.05e-02 | 36 |
GO:00181076 | Cervix | CC | peptidyl-threonine phosphorylation | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:19035334 | Cervix | CC | regulation of protein targeting | 19/2311 | 81/18723 | 3.96e-03 | 2.48e-02 | 19 |
GO:00182106 | Cervix | CC | peptidyl-threonine modification | 26/2311 | 125/18723 | 4.98e-03 | 2.97e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEMIP | SNV | Missense_Mutation | novel | c.1733N>T | p.Arg578Met | p.R578M | Q8WUJ3 | protein_coding | deleterious(0.03) | benign(0.293) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CEMIP | SNV | Missense_Mutation | c.4027C>T | p.His1343Tyr | p.H1343Y | Q8WUJ3 | protein_coding | tolerated(0.13) | benign(0) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
CEMIP | SNV | Missense_Mutation | novel | c.2713N>T | p.Ala905Ser | p.A905S | Q8WUJ3 | protein_coding | deleterious(0.01) | possibly_damaging(0.836) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CEMIP | SNV | Missense_Mutation | c.1677N>A | p.Phe559Leu | p.F559L | Q8WUJ3 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
CEMIP | SNV | Missense_Mutation | c.2246N>T | p.Ser749Phe | p.S749F | Q8WUJ3 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEMIP | SNV | Missense_Mutation | c.3226N>A | p.Asp1076Asn | p.D1076N | Q8WUJ3 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEMIP | SNV | Missense_Mutation | c.1667N>T | p.Pro556Leu | p.P556L | Q8WUJ3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEMIP | SNV | Missense_Mutation | c.2233N>G | p.Thr745Ala | p.T745A | Q8WUJ3 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEMIP | SNV | Missense_Mutation | c.3340T>G | p.Leu1114Val | p.L1114V | Q8WUJ3 | protein_coding | tolerated(0.51) | benign(0.01) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR | |
CEMIP | SNV | Missense_Mutation | c.2213T>C | p.Ile738Thr | p.I738T | Q8WUJ3 | protein_coding | deleterious(0.02) | possibly_damaging(0.838) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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