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Gene: CDK19 |
Gene summary for CDK19 |
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Gene information | Species | Human | Gene symbol | CDK19 | Gene ID | 23097 |
Gene name | cyclin dependent kinase 19 | |
Gene Alias | CDC2L6 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | I6W807 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23097 | CDK19 | CCI_2 | Human | Cervix | CC | 1.26e-04 | 7.86e-01 | 0.5249 |
23097 | CDK19 | CCI_3 | Human | Cervix | CC | 2.20e-11 | 9.70e-01 | 0.516 |
23097 | CDK19 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.89e-08 | 5.19e-01 | -0.1954 |
23097 | CDK19 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.97e-02 | -2.50e-01 | 0.3005 |
23097 | CDK19 | A015-C-203 | Human | Colorectum | FAP | 1.88e-14 | -2.41e-01 | -0.1294 |
23097 | CDK19 | A015-C-204 | Human | Colorectum | FAP | 3.11e-02 | -2.51e-01 | -0.0228 |
23097 | CDK19 | A002-C-201 | Human | Colorectum | FAP | 2.14e-05 | -1.09e-01 | 0.0324 |
23097 | CDK19 | A001-C-108 | Human | Colorectum | FAP | 8.54e-07 | -1.60e-01 | -0.0272 |
23097 | CDK19 | A002-C-205 | Human | Colorectum | FAP | 5.46e-12 | -2.56e-01 | -0.1236 |
23097 | CDK19 | A015-C-006 | Human | Colorectum | FAP | 1.03e-08 | -3.48e-01 | -0.0994 |
23097 | CDK19 | A015-C-106 | Human | Colorectum | FAP | 3.77e-04 | -1.59e-01 | -0.0511 |
23097 | CDK19 | A002-C-114 | Human | Colorectum | FAP | 3.73e-10 | -2.99e-01 | -0.1561 |
23097 | CDK19 | A015-C-104 | Human | Colorectum | FAP | 1.78e-15 | -2.79e-01 | -0.1899 |
23097 | CDK19 | A001-C-014 | Human | Colorectum | FAP | 3.40e-04 | -1.83e-01 | 0.0135 |
23097 | CDK19 | A002-C-016 | Human | Colorectum | FAP | 6.48e-09 | -1.00e-01 | 0.0521 |
23097 | CDK19 | A015-C-002 | Human | Colorectum | FAP | 1.95e-06 | -3.24e-01 | -0.0763 |
23097 | CDK19 | A001-C-203 | Human | Colorectum | FAP | 8.37e-04 | -7.65e-02 | -0.0481 |
23097 | CDK19 | A002-C-116 | Human | Colorectum | FAP | 9.55e-18 | -2.21e-01 | -0.0452 |
23097 | CDK19 | A014-C-008 | Human | Colorectum | FAP | 1.38e-07 | -3.56e-01 | -0.191 |
23097 | CDK19 | A018-E-020 | Human | Colorectum | FAP | 2.02e-08 | -2.49e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:00022379 | Cervix | CC | response to molecule of bacterial origin | 78/2311 | 363/18723 | 5.55e-07 | 2.06e-05 | 78 |
GO:00324969 | Cervix | CC | response to lipopolysaccharide | 74/2311 | 343/18723 | 9.15e-07 | 3.25e-05 | 74 |
GO:00313494 | Cervix | CC | positive regulation of defense response | 60/2311 | 278/18723 | 9.38e-06 | 2.11e-04 | 60 |
GO:00507273 | Cervix | CC | regulation of inflammatory response | 75/2311 | 386/18723 | 3.95e-05 | 6.18e-04 | 75 |
GO:00507294 | Cervix | CC | positive regulation of inflammatory response | 34/2311 | 142/18723 | 9.51e-05 | 1.25e-03 | 34 |
GO:00712228 | Cervix | CC | cellular response to lipopolysaccharide | 41/2311 | 209/18723 | 1.69e-03 | 1.29e-02 | 41 |
GO:00712168 | Cervix | CC | cellular response to biotic stimulus | 46/2311 | 246/18723 | 2.53e-03 | 1.76e-02 | 46 |
GO:00712198 | Cervix | CC | cellular response to molecule of bacterial origin | 42/2311 | 221/18723 | 2.79e-03 | 1.87e-02 | 42 |
GO:000223710 | Endometrium | AEH | response to molecule of bacterial origin | 65/2100 | 363/18723 | 9.00e-05 | 1.30e-03 | 65 |
GO:003249610 | Endometrium | AEH | response to lipopolysaccharide | 62/2100 | 343/18723 | 9.82e-05 | 1.41e-03 | 62 |
GO:00321036 | Endometrium | AEH | positive regulation of response to external stimulus | 68/2100 | 427/18723 | 1.82e-03 | 1.44e-02 | 68 |
GO:00712229 | Endometrium | AEH | cellular response to lipopolysaccharide | 37/2100 | 209/18723 | 3.30e-03 | 2.31e-02 | 37 |
GO:00712169 | Endometrium | AEH | cellular response to biotic stimulus | 42/2100 | 246/18723 | 3.65e-03 | 2.50e-02 | 42 |
GO:00712199 | Endometrium | AEH | cellular response to molecule of bacterial origin | 37/2100 | 221/18723 | 8.34e-03 | 4.56e-02 | 37 |
GO:000223714 | Endometrium | EEC | response to molecule of bacterial origin | 68/2168 | 363/18723 | 3.96e-05 | 6.64e-04 | 68 |
GO:003249614 | Endometrium | EEC | response to lipopolysaccharide | 65/2168 | 343/18723 | 4.04e-05 | 6.75e-04 | 65 |
GO:007122213 | Endometrium | EEC | cellular response to lipopolysaccharide | 40/2168 | 209/18723 | 9.31e-04 | 8.37e-03 | 40 |
GO:003210313 | Endometrium | EEC | positive regulation of response to external stimulus | 71/2168 | 427/18723 | 1.06e-03 | 9.18e-03 | 71 |
GO:007121613 | Endometrium | EEC | cellular response to biotic stimulus | 45/2168 | 246/18723 | 1.24e-03 | 1.03e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDK19 | SNV | Missense_Mutation | c.760N>T | p.Arg254Trp | p.R254W | Q9BWU1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDK19 | SNV | Missense_Mutation | c.510N>C | p.Lys170Asn | p.K170N | Q9BWU1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CDK19 | SNV | Missense_Mutation | c.761N>A | p.Arg254Gln | p.R254Q | Q9BWU1 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDK19 | SNV | Missense_Mutation | novel | c.830C>A | p.Pro277His | p.P277H | Q9BWU1 | protein_coding | tolerated(0.19) | benign(0.033) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDK19 | SNV | Missense_Mutation | c.334C>T | p.Arg112Cys | p.R112C | Q9BWU1 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
CDK19 | SNV | Missense_Mutation | c.436N>C | p.Trp146Arg | p.W146R | Q9BWU1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CDK19 | SNV | Missense_Mutation | rs774291402 | c.1322N>A | p.Arg441Gln | p.R441Q | Q9BWU1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.434) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK19 | SNV | Missense_Mutation | novel | c.233N>C | p.Val78Ala | p.V78A | Q9BWU1 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK19 | SNV | Missense_Mutation | rs781628403 | c.1367N>T | p.Ser456Leu | p.S456L | Q9BWU1 | protein_coding | deleterious_low_confidence(0) | benign(0.122) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
CDK19 | SNV | Missense_Mutation | novel | c.169N>G | p.Thr57Ala | p.T57A | Q9BWU1 | protein_coding | deleterious(0.02) | benign(0.158) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | 252827368 | PEXIDARTINIB | |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | CHEMBL3544942 | RONICICLIB | |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | 178102513 | PONATINIB | |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | TOZASERTIB | TOZASERTIB | ||
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | 315661253 | ||
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | 178102337 | SORAFENIB | |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | SNS-314 | SNS-314 | ||
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | CHEMBL488436 | AZD-5438 | |
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | inhibitor | 310264726 | ||
23097 | CDK19 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR | ALSTERPAULLONE | ALSTERPAULLONE |
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