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Gene: CDCA5 |
Gene summary for CDCA5 |
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Gene information | Species | Human | Gene symbol | CDCA5 | Gene ID | 113130 |
Gene name | cell division cycle associated 5 | |
Gene Alias | SORORIN | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A024R5D6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113130 | CDCA5 | P2T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.90e-01 | 0.1177 |
113130 | CDCA5 | P4T-E | Human | Esophagus | ESCC | 2.10e-11 | 4.07e-01 | 0.1323 |
113130 | CDCA5 | P5T-E | Human | Esophagus | ESCC | 1.53e-19 | 4.20e-01 | 0.1327 |
113130 | CDCA5 | P10T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.66e-01 | 0.116 |
113130 | CDCA5 | P15T-E | Human | Esophagus | ESCC | 1.50e-02 | 2.12e-01 | 0.1149 |
113130 | CDCA5 | P16T-E | Human | Esophagus | ESCC | 9.56e-08 | 2.72e-01 | 0.1153 |
113130 | CDCA5 | P17T-E | Human | Esophagus | ESCC | 1.41e-03 | 3.41e-01 | 0.1278 |
113130 | CDCA5 | P21T-E | Human | Esophagus | ESCC | 9.35e-10 | 3.41e-01 | 0.1617 |
113130 | CDCA5 | P24T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.88e-01 | 0.1287 |
113130 | CDCA5 | P28T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.53e-01 | 0.1149 |
113130 | CDCA5 | P31T-E | Human | Esophagus | ESCC | 9.02e-11 | 3.43e-01 | 0.1251 |
113130 | CDCA5 | P32T-E | Human | Esophagus | ESCC | 2.20e-17 | 4.77e-01 | 0.1666 |
113130 | CDCA5 | P37T-E | Human | Esophagus | ESCC | 2.31e-04 | 2.21e-01 | 0.1371 |
113130 | CDCA5 | P38T-E | Human | Esophagus | ESCC | 9.50e-06 | 3.29e-01 | 0.127 |
113130 | CDCA5 | P42T-E | Human | Esophagus | ESCC | 3.92e-05 | 3.55e-01 | 0.1175 |
113130 | CDCA5 | P48T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.16e-01 | 0.0959 |
113130 | CDCA5 | P52T-E | Human | Esophagus | ESCC | 5.00e-17 | 5.16e-01 | 0.1555 |
113130 | CDCA5 | P56T-E | Human | Esophagus | ESCC | 9.88e-07 | 6.69e-01 | 0.1613 |
113130 | CDCA5 | P75T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.97e-01 | 0.1125 |
113130 | CDCA5 | P76T-E | Human | Esophagus | ESCC | 9.56e-08 | 3.23e-01 | 0.1207 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:003450211 | Esophagus | ESCC | protein localization to chromosome | 70/8552 | 92/18723 | 2.54e-09 | 5.64e-08 | 70 |
GO:004593116 | Esophagus | ESCC | positive regulation of mitotic cell cycle | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDCA5 | SNV | Missense_Mutation | c.575C>G | p.Pro192Arg | p.P192R | Q96FF9 | protein_coding | tolerated(0.06) | possibly_damaging(0.837) | TCGA-18-4721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDCA5 | SNV | Missense_Mutation | novel | c.86N>T | p.Ser29Phe | p.S29F | Q96FF9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CDCA5 | SNV | Missense_Mutation | novel | c.735G>C | p.Glu245Asp | p.E245D | Q96FF9 | protein_coding | deleterious(0.03) | probably_damaging(0.987) | TCGA-CQ-5331-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDCA5 | SNV | Missense_Mutation | novel | c.44N>G | p.Ser15Cys | p.S15C | Q96FF9 | protein_coding | deleterious(0.02) | possibly_damaging(0.879) | TCGA-CQ-A4CD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDCA5 | SNV | Missense_Mutation | novel | c.35N>G | p.Ala12Gly | p.A12G | Q96FF9 | protein_coding | deleterious(0.05) | benign(0.142) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
CDCA5 | SNV | Missense_Mutation | novel | c.347C>A | p.Pro116His | p.P116H | Q96FF9 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CDCA5 | deletion | Frame_Shift_Del | novel | c.59delN | p.Pro20HisfsTer41 | p.P20Hfs*41 | Q96FF9 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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