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Gene: CDC40 |
Gene summary for CDC40 |
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Gene information | Species | Human | Gene symbol | CDC40 | Gene ID | 51362 |
Gene name | cell division cycle 40 | |
Gene Alias | EHB3 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O60508 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51362 | CDC40 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.36e-06 | 3.58e-01 | -0.1808 |
51362 | CDC40 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.12e-11 | 4.97e-01 | -0.0811 |
51362 | CDC40 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.88e-07 | 3.09e-01 | -0.1954 |
51362 | CDC40 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.15e-05 | 3.62e-01 | -0.1207 |
51362 | CDC40 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.15e-07 | 4.76e-01 | -0.1526 |
51362 | CDC40 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.99e-26 | 7.34e-01 | -0.1464 |
51362 | CDC40 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.35e-17 | 6.31e-01 | -0.059 |
51362 | CDC40 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.71e-04 | 5.38e-01 | -0.1706 |
51362 | CDC40 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.32e-02 | 4.58e-01 | -0.2061 |
51362 | CDC40 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.66e-05 | 6.64e-01 | -0.1462 |
51362 | CDC40 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.07e-04 | 5.31e-01 | 0.0112 |
51362 | CDC40 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.14e-03 | 2.99e-01 | 0.0588 |
51362 | CDC40 | A015-C-203 | Human | Colorectum | FAP | 2.96e-03 | -8.38e-02 | -0.1294 |
51362 | CDC40 | A015-C-104 | Human | Colorectum | FAP | 1.28e-03 | -1.07e-01 | -0.1899 |
51362 | CDC40 | A002-C-116 | Human | Colorectum | FAP | 1.87e-04 | -9.73e-02 | -0.0452 |
51362 | CDC40 | LZE4T | Human | Esophagus | ESCC | 2.16e-21 | 7.32e-01 | 0.0811 |
51362 | CDC40 | LZE7T | Human | Esophagus | ESCC | 2.93e-07 | 4.68e-01 | 0.0667 |
51362 | CDC40 | LZE8T | Human | Esophagus | ESCC | 6.53e-07 | 2.13e-01 | 0.067 |
51362 | CDC40 | LZE20T | Human | Esophagus | ESCC | 7.65e-08 | 2.39e-01 | 0.0662 |
51362 | CDC40 | LZE21D1 | Human | Esophagus | HGIN | 2.44e-05 | 5.73e-01 | 0.0632 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00003754 | Colorectum | FAP | RNA splicing, via transesterification reactions | 84/2622 | 324/18723 | 8.06e-09 | 1.10e-06 | 84 |
GO:00003774 | Colorectum | FAP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:00003984 | Colorectum | FAP | mRNA splicing, via spliceosome | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC40 | SNV | Missense_Mutation | rs375400280 | c.346N>A | p.Glu116Lys | p.E116K | O60508 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC40 | SNV | Missense_Mutation | novel | c.839N>G | p.Gln280Arg | p.Q280R | O60508 | protein_coding | tolerated(0.3) | benign(0.062) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDC40 | SNV | Missense_Mutation | c.952G>T | p.Val318Phe | p.V318F | O60508 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
CDC40 | SNV | Missense_Mutation | novel | c.292N>A | p.Pro98Thr | p.P98T | O60508 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDC40 | SNV | Missense_Mutation | c.844N>A | p.His282Asn | p.H282N | O60508 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDC40 | SNV | Missense_Mutation | novel | c.1473N>T | p.Gln491His | p.Q491H | O60508 | protein_coding | tolerated(0.57) | benign(0.014) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CDC40 | insertion | Frame_Shift_Ins | novel | c.678dupA | p.Gly227ArgfsTer18 | p.G227Rfs*18 | O60508 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
CDC40 | SNV | Missense_Mutation | novel | c.1648N>A | p.Asp550Asn | p.D550N | O60508 | protein_coding | deleterious(0.05) | benign(0.188) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDC40 | SNV | Missense_Mutation | novel | c.1061N>T | p.Arg354Met | p.R354M | O60508 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
CDC40 | SNV | Missense_Mutation | rs748401273 | c.964N>T | p.Arg322Trp | p.R322W | O60508 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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