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Gene: CDC23 |
Gene summary for CDC23 |
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Gene information | Species | Human | Gene symbol | CDC23 | Gene ID | 8697 |
Gene name | cell division cycle 23 | |
Gene Alias | ANAPC8 | |
Cytomap | 5q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9UJX2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8697 | CDC23 | LZE4T | Human | Esophagus | ESCC | 1.12e-08 | 1.95e-01 | 0.0811 |
8697 | CDC23 | LZE8T | Human | Esophagus | ESCC | 3.86e-03 | 1.09e-01 | 0.067 |
8697 | CDC23 | LZE24T | Human | Esophagus | ESCC | 3.39e-13 | 2.38e-01 | 0.0596 |
8697 | CDC23 | P2T-E | Human | Esophagus | ESCC | 2.76e-21 | 3.87e-01 | 0.1177 |
8697 | CDC23 | P4T-E | Human | Esophagus | ESCC | 3.67e-16 | 3.57e-01 | 0.1323 |
8697 | CDC23 | P5T-E | Human | Esophagus | ESCC | 4.80e-27 | 4.68e-01 | 0.1327 |
8697 | CDC23 | P8T-E | Human | Esophagus | ESCC | 8.03e-10 | 1.58e-01 | 0.0889 |
8697 | CDC23 | P9T-E | Human | Esophagus | ESCC | 2.49e-12 | 1.94e-01 | 0.1131 |
8697 | CDC23 | P10T-E | Human | Esophagus | ESCC | 3.19e-21 | 2.87e-01 | 0.116 |
8697 | CDC23 | P11T-E | Human | Esophagus | ESCC | 5.30e-10 | 4.06e-01 | 0.1426 |
8697 | CDC23 | P12T-E | Human | Esophagus | ESCC | 2.38e-24 | 5.17e-01 | 0.1122 |
8697 | CDC23 | P15T-E | Human | Esophagus | ESCC | 4.63e-19 | 4.06e-01 | 0.1149 |
8697 | CDC23 | P16T-E | Human | Esophagus | ESCC | 4.29e-16 | 3.11e-01 | 0.1153 |
8697 | CDC23 | P17T-E | Human | Esophagus | ESCC | 9.24e-09 | 2.82e-01 | 0.1278 |
8697 | CDC23 | P19T-E | Human | Esophagus | ESCC | 5.86e-03 | 3.29e-01 | 0.1662 |
8697 | CDC23 | P20T-E | Human | Esophagus | ESCC | 4.52e-24 | 4.71e-01 | 0.1124 |
8697 | CDC23 | P21T-E | Human | Esophagus | ESCC | 4.93e-19 | 3.68e-01 | 0.1617 |
8697 | CDC23 | P22T-E | Human | Esophagus | ESCC | 6.45e-20 | 2.06e-01 | 0.1236 |
8697 | CDC23 | P23T-E | Human | Esophagus | ESCC | 1.53e-05 | 1.39e-01 | 0.108 |
8697 | CDC23 | P24T-E | Human | Esophagus | ESCC | 2.27e-15 | 1.73e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa041146 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0411411 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa04114 | Oral cavity | OSCC | Oocyte meiosis | 74/3704 | 131/8465 | 2.13e-03 | 5.75e-03 | 2.92e-03 | 74 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC23 | SNV | Missense_Mutation | c.1486N>T | p.Asp496Tyr | p.D496Y | Q9UJX2 | protein_coding | deleterious(0) | benign(0.119) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CDC23 | SNV | Missense_Mutation | c.1301N>A | p.Arg434His | p.R434H | Q9UJX2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CDC23 | SNV | Missense_Mutation | c.413N>C | p.Leu138Ser | p.L138S | Q9UJX2 | protein_coding | tolerated(0.55) | benign(0.173) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CDC23 | SNV | Missense_Mutation | novel | c.69N>A | p.Asn23Lys | p.N23K | Q9UJX2 | protein_coding | tolerated_low_confidence(0.25) | benign(0.026) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD |
CDC23 | insertion | Frame_Shift_Ins | novel | c.699dupT | p.Leu234SerfsTer23 | p.L234Sfs*23 | Q9UJX2 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||
CDC23 | SNV | Missense_Mutation | novel | c.1669N>T | p.Arg557Trp | p.R557W | Q9UJX2 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDC23 | SNV | Missense_Mutation | novel | c.1084C>A | p.Pro362Thr | p.P362T | Q9UJX2 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CDC23 | SNV | Missense_Mutation | rs374640902 | c.449N>T | p.Ala150Val | p.A150V | Q9UJX2 | protein_coding | tolerated(0.49) | benign(0.005) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDC23 | SNV | Missense_Mutation | c.932N>T | p.Ser311Ile | p.S311I | Q9UJX2 | protein_coding | deleterious(0) | benign(0.01) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDC23 | SNV | Missense_Mutation | novel | c.1670G>A | p.Arg557Gln | p.R557Q | Q9UJX2 | protein_coding | deleterious(0.04) | benign(0.143) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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