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Gene: CDA |
Gene summary for CDA |
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Gene information | Species | Human | Gene symbol | CDA | Gene ID | 978 |
Gene name | cytidine deaminase | |
Gene Alias | CDD | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P32320 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
978 | CDA | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.18e-09 | 6.85e-01 | -0.1808 |
978 | CDA | HTA11_411_2000001011 | Human | Colorectum | SER | 5.83e-08 | 1.40e+00 | -0.2602 |
978 | CDA | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.02e-06 | 8.66e-01 | -0.2196 |
978 | CDA | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.59e-03 | 2.32e-01 | -0.1207 |
978 | CDA | HTA11_696_2000001011 | Human | Colorectum | AD | 6.48e-05 | 4.07e-01 | -0.1464 |
978 | CDA | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.57e-06 | 6.60e-01 | -0.2061 |
978 | CDA | P4T-E | Human | Esophagus | ESCC | 2.13e-05 | 1.75e-01 | 0.1323 |
978 | CDA | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.73e-01 | 0.1327 |
978 | CDA | P9T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.74e-01 | 0.1131 |
978 | CDA | P17T-E | Human | Esophagus | ESCC | 6.50e-11 | 7.65e-01 | 0.1278 |
978 | CDA | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.73e-02 | 0.1287 |
978 | CDA | P26T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.62e-01 | 0.1276 |
978 | CDA | P27T-E | Human | Esophagus | ESCC | 1.35e-07 | 2.28e-01 | 0.1055 |
978 | CDA | P28T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.29e-01 | 0.1149 |
978 | CDA | P31T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.85e-01 | 0.1251 |
978 | CDA | P36T-E | Human | Esophagus | ESCC | 6.01e-08 | 4.00e-01 | 0.1187 |
978 | CDA | P37T-E | Human | Esophagus | ESCC | 1.63e-62 | 1.78e+00 | 0.1371 |
978 | CDA | P38T-E | Human | Esophagus | ESCC | 3.72e-13 | 8.23e-01 | 0.127 |
978 | CDA | P49T-E | Human | Esophagus | ESCC | 1.92e-16 | 1.33e+00 | 0.1768 |
978 | CDA | P52T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.62e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:0045926 | Colorectum | AD | negative regulation of growth | 70/3918 | 249/18723 | 4.07e-03 | 2.83e-02 | 70 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00105631 | Colorectum | SER | negative regulation of phosphorus metabolic process | 101/2897 | 442/18723 | 2.39e-05 | 6.70e-04 | 101 |
GO:00459361 | Colorectum | SER | negative regulation of phosphate metabolic process | 100/2897 | 441/18723 | 3.62e-05 | 9.39e-04 | 100 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDA | SNV | Missense_Mutation | c.43N>T | p.Val15Phe | p.V15F | P32320 | protein_coding | deleterious(0.02) | benign(0.322) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CDA | SNV | Missense_Mutation | c.182C>A | p.Pro61Gln | p.P61Q | P32320 | protein_coding | deleterious(0.05) | possibly_damaging(0.673) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
978 | CDA | ENZYME, DRUGGABLE GENOME | CYTARABINE | CYTARABINE | 12008078 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | cytarabine | CYTARABINE | 21325291,21521023,22304580,22379997,25003625,19458626,23651026,23230131,18473752 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | Tetrahydrouridine | TETRAHYDROURIDINE | ||
978 | CDA | ENZYME, DRUGGABLE GENOME | DEOXYCYTIDINE | DEOXYCYTIDINE | 12008078 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | capecitabine | CAPECITABINE | 21325291,24167597,28347776,18473752,23736036 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | GEMCITABINE | GEMCITABINE | 12477049 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | TETRAHYDROURIDINE | TETRAHYDROURIDINE | 2932216 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | difluorodeoxyuridine | 22838949 | ||
978 | CDA | ENZYME, DRUGGABLE GENOME | azacitidine | AZACITIDINE | 25850965 | |
978 | CDA | ENZYME, DRUGGABLE GENOME | ARA-C | 8791999,12008078 |
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