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Gene: CCL4L2 |
Gene summary for CCL4L2 |
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Gene information | Species | Human | Gene symbol | CCL4L2 | Gene ID | 9560 |
Gene name | C-C motif chemokine ligand 4 like 2 | |
Gene Alias | AT744.2 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8NHW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9560 | CCL4L2 | C21 | Human | Oral cavity | OSCC | 1.05e-51 | 1.57e+00 | 0.2678 |
9560 | CCL4L2 | C30 | Human | Oral cavity | OSCC | 1.69e-49 | 1.72e+00 | 0.3055 |
9560 | CCL4L2 | C38 | Human | Oral cavity | OSCC | 1.16e-02 | 1.35e+00 | 0.172 |
9560 | CCL4L2 | C46 | Human | Oral cavity | OSCC | 5.19e-19 | 2.21e-01 | 0.1673 |
9560 | CCL4L2 | C51 | Human | Oral cavity | OSCC | 6.74e-04 | 1.60e-01 | 0.2674 |
9560 | CCL4L2 | C07 | Human | Oral cavity | OSCC | 1.88e-03 | 5.39e-01 | 0.2491 |
9560 | CCL4L2 | C09 | Human | Oral cavity | OSCC | 7.91e-12 | 1.27e-01 | 0.1431 |
9560 | CCL4L2 | LN22 | Human | Oral cavity | OSCC | 1.03e-04 | 5.12e-01 | 0.1733 |
9560 | CCL4L2 | LN46 | Human | Oral cavity | OSCC | 3.90e-08 | 2.89e-01 | 0.1666 |
9560 | CCL4L2 | SYSMH6 | Human | Oral cavity | OSCC | 6.61e-20 | 1.46e-01 | 0.1275 |
9560 | CCL4L2 | PTCwithHT_1 | Human | Thyroid | HT | 2.77e-26 | 1.51e+00 | 0.0238 |
9560 | CCL4L2 | PTCwithHT_6 | Human | Thyroid | HT | 1.78e-21 | 9.11e-01 | 0.02 |
9560 | CCL4L2 | PTCwithHT_8 | Human | Thyroid | HT | 6.49e-27 | 1.12e+00 | 0.0351 |
9560 | CCL4L2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 5.62e-15 | 8.26e-01 | 0.0419 |
9560 | CCL4L2 | PTCwithoutHT_7 | Human | Thyroid | PTC | 3.58e-09 | 9.64e-01 | 0.0381 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516328 | Oral cavity | OSCC | Human cytomegalovirus infection | 139/3704 | 225/8465 | 2.77e-08 | 2.38e-07 | 1.21e-07 | 139 |
hsa040644 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa04620 | Oral cavity | OSCC | Toll-like receptor signaling pathway | 58/3704 | 104/8465 | 8.77e-03 | 1.98e-02 | 1.01e-02 | 58 |
hsa05163112 | Oral cavity | OSCC | Human cytomegalovirus infection | 139/3704 | 225/8465 | 2.77e-08 | 2.38e-07 | 1.21e-07 | 139 |
hsa0406411 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa046201 | Oral cavity | OSCC | Toll-like receptor signaling pathway | 58/3704 | 104/8465 | 8.77e-03 | 1.98e-02 | 1.01e-02 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCL4L2 | SNV | Missense_Mutation | novel | c.178N>G | p.Gln60Glu | p.Q60E | Q8NHW4 | protein_coding | tolerated(0.06) | benign(0.012) | TCGA-F1-6875-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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