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Gene: CCDC57 |
Gene summary for CCDC57 |
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Gene information | Species | Human | Gene symbol | CCDC57 | Gene ID | 284001 |
Gene name | coiled-coil domain containing 57 | |
Gene Alias | CCDC57 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q2TAC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284001 | CCDC57 | GSM4909281 | Human | Breast | IDC | 2.15e-03 | -1.81e-01 | 0.21 |
284001 | CCDC57 | GSM4909285 | Human | Breast | IDC | 1.75e-03 | -1.73e-01 | 0.21 |
284001 | CCDC57 | GSM4909286 | Human | Breast | IDC | 1.33e-03 | 1.53e-01 | 0.1081 |
284001 | CCDC57 | GSM4909293 | Human | Breast | IDC | 9.34e-14 | 4.19e-01 | 0.1581 |
284001 | CCDC57 | GSM4909306 | Human | Breast | IDC | 7.50e-03 | 3.27e-01 | 0.1564 |
284001 | CCDC57 | GSM4909308 | Human | Breast | IDC | 4.46e-02 | 1.95e-01 | 0.158 |
284001 | CCDC57 | GSM4909311 | Human | Breast | IDC | 2.73e-10 | -1.16e-01 | 0.1534 |
284001 | CCDC57 | GSM4909312 | Human | Breast | IDC | 6.35e-04 | -1.27e-01 | 0.1552 |
284001 | CCDC57 | GSM4909319 | Human | Breast | IDC | 2.00e-21 | 1.58e-01 | 0.1563 |
284001 | CCDC57 | brca1 | Human | Breast | Precancer | 1.06e-03 | -1.84e-01 | -0.0338 |
284001 | CCDC57 | M1 | Human | Breast | IDC | 6.85e-49 | 1.12e+00 | 0.1577 |
284001 | CCDC57 | NCCBC14 | Human | Breast | DCIS | 7.77e-03 | -2.19e-02 | 0.2021 |
284001 | CCDC57 | P1 | Human | Breast | IDC | 4.50e-15 | 5.17e-01 | 0.1527 |
284001 | CCDC57 | DCIS2 | Human | Breast | DCIS | 2.00e-52 | 6.64e-02 | 0.0085 |
284001 | CCDC57 | LZE4T | Human | Esophagus | ESCC | 6.86e-07 | 2.33e-01 | 0.0811 |
284001 | CCDC57 | LZE7T | Human | Esophagus | ESCC | 8.24e-06 | 4.25e-01 | 0.0667 |
284001 | CCDC57 | LZE8T | Human | Esophagus | ESCC | 1.21e-05 | 1.99e-01 | 0.067 |
284001 | CCDC57 | LZE20T | Human | Esophagus | ESCC | 3.04e-04 | 1.20e-01 | 0.0662 |
284001 | CCDC57 | LZE21D1 | Human | Esophagus | HGIN | 7.88e-04 | 4.19e-01 | 0.0632 |
284001 | CCDC57 | LZE22D1 | Human | Esophagus | HGIN | 2.71e-09 | 2.60e-01 | 0.0595 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512589 | Breast | IDC | protein polymerization | 38/1434 | 297/18723 | 1.26e-03 | 1.34e-02 | 38 |
GO:00073465 | Breast | IDC | regulation of mitotic cell cycle | 51/1434 | 457/18723 | 4.30e-03 | 3.35e-02 | 51 |
GO:00459315 | Breast | IDC | positive regulation of mitotic cell cycle | 18/1434 | 121/18723 | 4.90e-03 | 3.73e-02 | 18 |
GO:005125814 | Breast | DCIS | protein polymerization | 39/1390 | 297/18723 | 3.64e-04 | 5.15e-03 | 39 |
GO:000734612 | Breast | DCIS | regulation of mitotic cell cycle | 52/1390 | 457/18723 | 1.38e-03 | 1.43e-02 | 52 |
GO:004593112 | Breast | DCIS | positive regulation of mitotic cell cycle | 19/1390 | 121/18723 | 1.47e-03 | 1.49e-02 | 19 |
GO:00447724 | Breast | DCIS | mitotic cell cycle phase transition | 46/1390 | 424/18723 | 6.16e-03 | 4.39e-02 | 46 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00447729 | Esophagus | HGIN | mitotic cell cycle phase transition | 89/2587 | 424/18723 | 2.80e-05 | 7.21e-04 | 89 |
GO:005125826 | Esophagus | HGIN | protein polymerization | 66/2587 | 297/18723 | 4.96e-05 | 1.19e-03 | 66 |
GO:004593110 | Esophagus | HGIN | positive regulation of mitotic cell cycle | 28/2587 | 121/18723 | 3.72e-03 | 3.39e-02 | 28 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00000864 | Esophagus | ESCC | G2/M transition of mitotic cell cycle | 96/8552 | 137/18723 | 6.00e-09 | 1.23e-07 | 96 |
GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
GO:004593116 | Esophagus | ESCC | positive regulation of mitotic cell cycle | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC57 | SNV | Missense_Mutation | rs59960805 | c.341N>A | p.Glu115Lys | p.E115K | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
CCDC57 | SNV | Missense_Mutation | rs768468881 | c.919G>A | p.Val307Met | p.V307M | Q2TAC2 | protein_coding | deleterious(0.05) | benign(0.01) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CCDC57 | SNV | Missense_Mutation | rs370460701 | c.83N>A | p.Arg28His | p.R28H | Q2TAC2 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC57 | SNV | Missense_Mutation | c.1517N>T | p.Arg506Met | p.R506M | Q2TAC2 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC57 | SNV | Missense_Mutation | rs577342436 | c.569N>A | p.Arg190His | p.R190H | Q2TAC2 | protein_coding | tolerated(0.08) | benign(0.097) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CCDC57 | SNV | Missense_Mutation | rs192389996 | c.397C>T | p.Arg133Cys | p.R133C | Q2TAC2 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCDC57 | SNV | Missense_Mutation | rs770033906 | c.772G>A | p.Ala258Thr | p.A258T | Q2TAC2 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCDC57 | SNV | Missense_Mutation | c.1523N>T | p.His508Leu | p.H508L | Q2TAC2 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-F4-6807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
CCDC57 | SNV | Missense_Mutation | c.941N>T | p.Arg314Met | p.R314M | protein_coding | deleterious_low_confidence(0.04) | benign(0.044) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | ||
CCDC57 | SNV | Missense_Mutation | novel | c.1010N>T | p.Arg337Ile | p.R337I | Q2TAC2 | protein_coding | tolerated(0.17) | benign(0.316) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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