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Gene: CBLL1 |
Gene summary for CBLL1 |
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Gene information | Species | Human | Gene symbol | CBLL1 | Gene ID | 79872 |
Gene name | Cbl proto-oncogene like 1 | |
Gene Alias | HAKAI | |
Cytomap | 7q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q75N03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79872 | CBLL1 | LZE4T | Human | Esophagus | ESCC | 5.46e-09 | 1.43e-01 | 0.0811 |
79872 | CBLL1 | LZE8T | Human | Esophagus | ESCC | 1.31e-02 | 5.87e-02 | 0.067 |
79872 | CBLL1 | LZE20T | Human | Esophagus | ESCC | 4.44e-02 | 1.32e-01 | 0.0662 |
79872 | CBLL1 | LZE24T | Human | Esophagus | ESCC | 1.45e-15 | 2.65e-01 | 0.0596 |
79872 | CBLL1 | LZE6T | Human | Esophagus | ESCC | 5.37e-03 | 1.11e-01 | 0.0845 |
79872 | CBLL1 | P1T-E | Human | Esophagus | ESCC | 2.67e-07 | 1.87e-01 | 0.0875 |
79872 | CBLL1 | P2T-E | Human | Esophagus | ESCC | 5.68e-13 | 1.28e-01 | 0.1177 |
79872 | CBLL1 | P4T-E | Human | Esophagus | ESCC | 6.40e-07 | 2.43e-01 | 0.1323 |
79872 | CBLL1 | P5T-E | Human | Esophagus | ESCC | 1.96e-12 | 1.10e-01 | 0.1327 |
79872 | CBLL1 | P8T-E | Human | Esophagus | ESCC | 1.45e-14 | 1.59e-01 | 0.0889 |
79872 | CBLL1 | P9T-E | Human | Esophagus | ESCC | 5.11e-12 | 1.63e-01 | 0.1131 |
79872 | CBLL1 | P10T-E | Human | Esophagus | ESCC | 2.14e-19 | 2.08e-01 | 0.116 |
79872 | CBLL1 | P11T-E | Human | Esophagus | ESCC | 7.52e-04 | 3.82e-01 | 0.1426 |
79872 | CBLL1 | P12T-E | Human | Esophagus | ESCC | 3.10e-16 | 3.34e-01 | 0.1122 |
79872 | CBLL1 | P15T-E | Human | Esophagus | ESCC | 2.73e-19 | 4.48e-01 | 0.1149 |
79872 | CBLL1 | P16T-E | Human | Esophagus | ESCC | 2.20e-20 | 1.91e-01 | 0.1153 |
79872 | CBLL1 | P17T-E | Human | Esophagus | ESCC | 5.53e-04 | 5.49e-01 | 0.1278 |
79872 | CBLL1 | P20T-E | Human | Esophagus | ESCC | 3.27e-31 | 8.01e-01 | 0.1124 |
79872 | CBLL1 | P21T-E | Human | Esophagus | ESCC | 1.22e-16 | 2.46e-01 | 0.1617 |
79872 | CBLL1 | P22T-E | Human | Esophagus | ESCC | 9.82e-14 | 1.17e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:004580718 | Esophagus | ESCC | positive regulation of endocytosis | 69/8552 | 100/18723 | 1.97e-06 | 2.29e-05 | 69 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00800092 | Esophagus | ESCC | mRNA methylation | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00165561 | Esophagus | ESCC | mRNA modification | 21/8552 | 27/18723 | 6.88e-04 | 3.61e-03 | 21 |
GO:003010011 | Liver | Cirrhotic | regulation of endocytosis | 74/4634 | 211/18723 | 4.86e-04 | 3.90e-03 | 74 |
GO:004580711 | Liver | Cirrhotic | positive regulation of endocytosis | 38/4634 | 100/18723 | 2.22e-03 | 1.35e-02 | 38 |
GO:00071624 | Liver | Cirrhotic | negative regulation of cell adhesion | 93/4634 | 303/18723 | 1.06e-02 | 4.66e-02 | 93 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:003010021 | Liver | HCC | regulation of endocytosis | 117/7958 | 211/18723 | 9.56e-05 | 8.32e-04 | 117 |
GO:004580721 | Liver | HCC | positive regulation of endocytosis | 59/7958 | 100/18723 | 6.35e-04 | 3.93e-03 | 59 |
GO:0080009 | Liver | HCC | mRNA methylation | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:0016556 | Liver | HCC | mRNA modification | 18/7958 | 27/18723 | 9.75e-03 | 3.66e-02 | 18 |
GO:00071628 | Prostate | BPH | negative regulation of cell adhesion | 82/3107 | 303/18723 | 2.51e-06 | 4.04e-05 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBLL1 | SNV | Missense_Mutation | c.710A>G | p.His237Arg | p.H237R | Q75N03 | protein_coding | tolerated(0.16) | probably_damaging(0.978) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CBLL1 | SNV | Missense_Mutation | rs781680484 | c.119C>T | p.Pro40Leu | p.P40L | Q75N03 | protein_coding | tolerated(0.69) | benign(0.046) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | novel | c.188T>G | p.Phe63Cys | p.F63C | Q75N03 | protein_coding | tolerated(0.22) | probably_damaging(0.947) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | c.655C>T | p.Arg219Cys | p.R219C | Q75N03 | protein_coding | tolerated(0.2) | possibly_damaging(0.872) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CBLL1 | SNV | Missense_Mutation | novel | c.139A>G | p.Thr47Ala | p.T47A | Q75N03 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | rs750032451 | c.1065G>A | p.Met355Ile | p.M355I | Q75N03 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | rs746716401 | c.476N>T | p.Thr159Ile | p.T159I | Q75N03 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | rs756843724 | c.74N>A | p.Arg25Gln | p.R25Q | Q75N03 | protein_coding | tolerated_low_confidence(0.21) | benign(0.061) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CBLL1 | SNV | Missense_Mutation | novel | c.502N>G | p.Ile168Val | p.I168V | Q75N03 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CBLL1 | SNV | Missense_Mutation | c.571A>G | p.Met191Val | p.M191V | Q75N03 | protein_coding | tolerated(0.26) | benign(0) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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