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Gene: CARD10 |
Gene summary for CARD10 |
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Gene information | Species | Human | Gene symbol | CARD10 | Gene ID | 29775 |
Gene name | caspase recruitment domain family member 10 | |
Gene Alias | BIMP1 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9BWT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29775 | CARD10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.78e-06 | 4.51e-01 | -0.1808 |
29775 | CARD10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.27e-09 | 3.75e-01 | -0.0811 |
29775 | CARD10 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.63e-02 | 2.83e-01 | -0.1088 |
29775 | CARD10 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.25e-05 | 2.36e-01 | -0.1954 |
29775 | CARD10 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.82e-03 | 6.98e-01 | -0.2602 |
29775 | CARD10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.04e-02 | 3.13e-01 | -0.1207 |
29775 | CARD10 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.61e-04 | 3.55e-01 | -0.1526 |
29775 | CARD10 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.87e-15 | 4.01e-01 | -0.1464 |
29775 | CARD10 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.71e-08 | 3.15e-01 | -0.1001 |
29775 | CARD10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.75e-09 | 4.28e-01 | -0.059 |
29775 | CARD10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.41e-06 | 2.79e-01 | 0.096 |
29775 | CARD10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.69e-11 | 3.32e-01 | 0.0674 |
29775 | CARD10 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.58e-02 | 2.12e-01 | 0.281 |
29775 | CARD10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.12e-10 | 3.54e-01 | 0.3859 |
29775 | CARD10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.59e-06 | 4.53e-01 | 0.2585 |
29775 | CARD10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.02e-04 | 2.09e-01 | 0.3005 |
29775 | CARD10 | HCC1_Meng | Human | Liver | HCC | 6.11e-29 | 8.61e-02 | 0.0246 |
29775 | CARD10 | HCC2_Meng | Human | Liver | HCC | 2.91e-09 | 9.39e-02 | 0.0107 |
29775 | CARD10 | HCC2 | Human | Liver | HCC | 4.32e-07 | 1.95e+00 | 0.5341 |
29775 | CARD10 | S014 | Human | Liver | HCC | 2.88e-15 | 6.29e-01 | 0.2254 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0043542 | Colorectum | AD | endothelial cell migration | 78/3918 | 279/18723 | 2.97e-03 | 2.22e-02 | 78 |
GO:19038291 | Colorectum | SER | positive regulation of cellular protein localization | 86/2897 | 276/18723 | 3.61e-11 | 6.11e-09 | 86 |
GO:19001801 | Colorectum | SER | regulation of protein localization to nucleus | 46/2897 | 136/18723 | 8.50e-08 | 5.27e-06 | 46 |
GO:19001821 | Colorectum | SER | positive regulation of protein localization to nucleus | 33/2897 | 87/18723 | 2.81e-07 | 1.52e-05 | 33 |
GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
GO:00016671 | Colorectum | SER | ameboidal-type cell migration | 105/2897 | 475/18723 | 6.97e-05 | 1.59e-03 | 105 |
GO:00901321 | Colorectum | SER | epithelium migration | 82/2897 | 360/18723 | 1.50e-04 | 2.93e-03 | 82 |
GO:00106311 | Colorectum | SER | epithelial cell migration | 81/2897 | 357/18723 | 1.87e-04 | 3.44e-03 | 81 |
GO:00901301 | Colorectum | SER | tissue migration | 82/2897 | 365/18723 | 2.40e-04 | 4.12e-03 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040644 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0406411 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CARD10 | SNV | Missense_Mutation | rs762915999 | c.1138N>T | p.Arg380Cys | p.R380C | Q9BWT7 | protein_coding | deleterious(0.03) | possibly_damaging(0.664) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CARD10 | SNV | Missense_Mutation | rs770715620 | c.1493N>C | p.Met498Thr | p.M498T | Q9BWT7 | protein_coding | tolerated(0.72) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD10 | SNV | Missense_Mutation | c.3095N>A | p.Ala1032Asp | p.A1032D | Q9BWT7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.503) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CARD10 | SNV | Missense_Mutation | novel | c.913N>A | p.Ala305Thr | p.A305T | Q9BWT7 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-G4-6311-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
CARD10 | SNV | Missense_Mutation | rs755453339 | c.2536N>T | p.Arg846Trp | p.R846W | Q9BWT7 | protein_coding | deleterious(0) | possibly_damaging(0.72) | TCGA-G4-6315-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
CARD10 | SNV | Missense_Mutation | rs550531365 | c.440N>A | p.Arg147His | p.R147H | Q9BWT7 | protein_coding | tolerated(0.48) | probably_damaging(0.967) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD10 | deletion | Frame_Shift_Del | novel | c.2685delN | p.Lys896ArgfsTer9 | p.K896Rfs*9 | Q9BWT7 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CARD10 | SNV | Missense_Mutation | rs372809047 | c.316N>A | p.Glu106Lys | p.E106K | Q9BWT7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CARD10 | SNV | Missense_Mutation | novel | c.1259N>A | p.Arg420His | p.R420H | Q9BWT7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD10 | SNV | Missense_Mutation | novel | c.2198N>A | p.Arg733Gln | p.R733Q | Q9BWT7 | protein_coding | deleterious(0.01) | possibly_damaging(0.574) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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