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Gene: CAPRIN2 |
Gene summary for CAPRIN2 |
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Gene information | Species | Human | Gene symbol | CAPRIN2 | Gene ID | 65981 |
Gene name | caprin family member 2 | |
Gene Alias | C1QDC1 | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q6IMN6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65981 | CAPRIN2 | HCC1_Meng | Human | Liver | HCC | 3.62e-08 | -1.38e-02 | 0.0246 |
65981 | CAPRIN2 | HCC2_Meng | Human | Liver | HCC | 7.08e-14 | 1.02e-01 | 0.0107 |
65981 | CAPRIN2 | HCC1 | Human | Liver | HCC | 1.31e-02 | 1.84e+00 | 0.5336 |
65981 | CAPRIN2 | HCC2 | Human | Liver | HCC | 2.40e-03 | 2.59e+00 | 0.5341 |
65981 | CAPRIN2 | S014 | Human | Liver | HCC | 1.36e-02 | 1.38e-01 | 0.2254 |
65981 | CAPRIN2 | S015 | Human | Liver | HCC | 1.37e-06 | 4.65e-01 | 0.2375 |
65981 | CAPRIN2 | S028 | Human | Liver | HCC | 1.99e-06 | 2.42e-01 | 0.2503 |
65981 | CAPRIN2 | male-WTA | Human | Thyroid | PTC | 2.84e-03 | 3.84e-02 | 0.1037 |
65981 | CAPRIN2 | PTC01 | Human | Thyroid | PTC | 4.11e-03 | 1.44e-02 | 0.1899 |
65981 | CAPRIN2 | PTC03 | Human | Thyroid | PTC | 3.50e-03 | 1.73e-01 | 0.1784 |
65981 | CAPRIN2 | PTC04 | Human | Thyroid | PTC | 1.47e-05 | 9.05e-02 | 0.1927 |
65981 | CAPRIN2 | PTC05 | Human | Thyroid | PTC | 6.14e-08 | 2.85e-01 | 0.2065 |
65981 | CAPRIN2 | PTC06 | Human | Thyroid | PTC | 2.36e-09 | 2.74e-01 | 0.2057 |
65981 | CAPRIN2 | PTC07 | Human | Thyroid | PTC | 1.39e-08 | 1.25e-01 | 0.2044 |
65981 | CAPRIN2 | ATC09 | Human | Thyroid | ATC | 2.40e-04 | 1.86e-01 | 0.2871 |
65981 | CAPRIN2 | ATC11 | Human | Thyroid | ATC | 2.61e-06 | 4.81e-01 | 0.3386 |
65981 | CAPRIN2 | ATC12 | Human | Thyroid | ATC | 3.40e-07 | 1.99e-01 | 0.34 |
65981 | CAPRIN2 | ATC13 | Human | Thyroid | ATC | 2.06e-39 | 6.74e-01 | 0.34 |
65981 | CAPRIN2 | ATC1 | Human | Thyroid | ATC | 1.81e-04 | 2.10e-01 | 0.2878 |
65981 | CAPRIN2 | ATC2 | Human | Thyroid | ATC | 1.89e-09 | 6.62e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
GO:004339322 | Liver | HCC | regulation of protein binding | 129/7958 | 196/18723 | 3.27e-11 | 1.26e-09 | 129 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:005109922 | Liver | HCC | positive regulation of binding | 108/7958 | 173/18723 | 9.22e-08 | 1.83e-06 | 108 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:003209221 | Liver | HCC | positive regulation of protein binding | 59/7958 | 85/18723 | 4.66e-07 | 7.61e-06 | 59 |
GO:001076922 | Liver | HCC | regulation of cell morphogenesis involved in differentiation | 65/7958 | 96/18723 | 5.17e-07 | 8.37e-06 | 65 |
GO:003134611 | Liver | HCC | positive regulation of cell projection organization | 193/7958 | 353/18723 | 2.28e-06 | 3.08e-05 | 193 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:001077022 | Liver | HCC | positive regulation of cell morphogenesis involved in differentiation | 53/7958 | 79/18723 | 8.69e-06 | 1.02e-04 | 53 |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
GO:003424921 | Liver | HCC | negative regulation of cellular amide metabolic process | 144/7958 | 273/18723 | 3.80e-04 | 2.61e-03 | 144 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPRIN2 | SNV | Missense_Mutation | c.748N>C | p.Glu250Gln | p.E250Q | Q6IMN6 | protein_coding | tolerated(0.19) | benign(0.376) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CAPRIN2 | SNV | Missense_Mutation | rs377678483 | c.2351N>A | p.Ser784Asn | p.S784N | Q6IMN6 | protein_coding | tolerated(0.1) | possibly_damaging(0.724) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CAPRIN2 | SNV | Missense_Mutation | c.3057N>T | p.Glu1019Asp | p.E1019D | Q6IMN6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPRIN2 | SNV | Missense_Mutation | novel | c.2840N>A | p.Arg947Gln | p.R947Q | Q6IMN6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPRIN2 | SNV | Missense_Mutation | c.889N>G | p.Thr297Ala | p.T297A | Q6IMN6 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CAPRIN2 | SNV | Missense_Mutation | novel | c.495N>T | p.Glu165Asp | p.E165D | Q6IMN6 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CAPRIN2 | SNV | Missense_Mutation | c.1924N>C | p.Asp642His | p.D642H | Q6IMN6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D5-6533-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | CR | |
CAPRIN2 | SNV | Missense_Mutation | c.2633N>A | p.Gly878Glu | p.G878E | Q6IMN6 | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPRIN2 | SNV | Missense_Mutation | c.37N>A | p.Glu13Lys | p.E13K | Q6IMN6 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CAPRIN2 | SNV | Missense_Mutation | c.3008A>C | p.Lys1003Thr | p.K1003T | Q6IMN6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6883-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5fluorouracil+leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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