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Gene: CADPS2 |
Gene summary for CADPS2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CADPS2 | Gene ID | 93664 |
Gene name | calcium dependent secretion activator 2 | |
Gene Alias | CAPS2 | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q86UW7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93664 | CADPS2 | CCI_3 | Human | Cervix | CC | 1.51e-11 | 8.69e-01 | 0.516 |
93664 | CADPS2 | H2 | Human | Cervix | HSIL_HPV | 1.04e-05 | 2.71e-01 | 0.0632 |
93664 | CADPS2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.15e-16 | -6.04e-01 | 0.0155 |
93664 | CADPS2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.09e-05 | -5.45e-01 | -0.1808 |
93664 | CADPS2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.14e-06 | -5.19e-01 | -0.1207 |
93664 | CADPS2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.06e-03 | -3.89e-01 | -0.1464 |
93664 | CADPS2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.02e-06 | -4.68e-01 | -0.1001 |
93664 | CADPS2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.47e-05 | -7.94e-01 | -0.2061 |
93664 | CADPS2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.06e-02 | -5.82e-01 | -0.0179 |
93664 | CADPS2 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.39e-08 | -4.74e-01 | 0.096 |
93664 | CADPS2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.09e-03 | -6.43e-01 | 0.0528 |
93664 | CADPS2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.77e-05 | -5.15e-01 | 0.0338 |
93664 | CADPS2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.02e-07 | -4.10e-01 | 0.0674 |
93664 | CADPS2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.35e-02 | -3.38e-01 | 0.3859 |
93664 | CADPS2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.49e-09 | -7.90e-01 | 0.2585 |
93664 | CADPS2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.02e-31 | -7.52e-01 | 0.3005 |
93664 | CADPS2 | A015-C-203 | Human | Colorectum | FAP | 3.70e-31 | -6.12e-01 | -0.1294 |
93664 | CADPS2 | A015-C-204 | Human | Colorectum | FAP | 4.43e-05 | -4.01e-01 | -0.0228 |
93664 | CADPS2 | A014-C-040 | Human | Colorectum | FAP | 5.91e-03 | -4.35e-01 | -0.1184 |
93664 | CADPS2 | A002-C-201 | Human | Colorectum | FAP | 7.12e-10 | -3.56e-01 | 0.0324 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00459211 | Colorectum | SER | positive regulation of exocytosis | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00510471 | Colorectum | SER | positive regulation of secretion | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00171571 | Colorectum | SER | regulation of exocytosis | 45/2897 | 202/18723 | 6.46e-03 | 4.63e-02 | 45 |
GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:00459212 | Colorectum | MSS | positive regulation of exocytosis | 27/3467 | 86/18723 | 2.76e-03 | 2.17e-02 | 27 |
GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
GO:00990032 | Colorectum | FAP | vesicle-mediated transport in synapse | 51/2622 | 200/18723 | 1.09e-05 | 3.08e-04 | 51 |
GO:00995041 | Colorectum | FAP | synaptic vesicle cycle | 45/2622 | 181/18723 | 6.73e-05 | 1.28e-03 | 45 |
GO:0023061 | Colorectum | FAP | signal release | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CADPS2 | SNV | Missense_Mutation | novel | c.2531N>A | p.Ala844Glu | p.A844E | Q86UW7 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-LL-A5YN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
CADPS2 | SNV | Missense_Mutation | c.1178N>G | p.Glu393Gly | p.E393G | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-C5-A1BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CADPS2 | SNV | Missense_Mutation | novel | c.2134N>G | p.Thr712Ala | p.T712A | Q86UW7 | protein_coding | tolerated(0.11) | benign(0.15) | TCGA-VS-A94Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CADPS2 | SNV | Missense_Mutation | novel | c.1081N>A | p.Val361Met | p.V361M | Q86UW7 | protein_coding | deleterious(0) | possibly_damaging(0.721) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CADPS2 | SNV | Missense_Mutation | c.1041N>A | p.Asp347Glu | p.D347E | Q86UW7 | protein_coding | tolerated(0.07) | probably_damaging(0.978) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CADPS2 | SNV | Missense_Mutation | rs368114197 | c.473N>A | p.Arg158Gln | p.R158Q | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CADPS2 | SNV | Missense_Mutation | rs756409034 | c.928N>T | p.Arg310Trp | p.R310W | Q86UW7 | protein_coding | deleterious(0.05) | possibly_damaging(0.857) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CADPS2 | SNV | Missense_Mutation | rs372484743 | c.551G>A | p.Arg184His | p.R184H | Q86UW7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CADPS2 | SNV | Missense_Mutation | novel | c.3853A>G | p.Ile1285Val | p.I1285V | Q86UW7 | protein_coding | tolerated_low_confidence(0.15) | benign(0.007) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CADPS2 | SNV | Missense_Mutation | rs771969548 | c.1442G>A | p.Arg481Gln | p.R481Q | Q86UW7 | protein_coding | deleterious(0) | possibly_damaging(0.652) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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