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Gene: CA7 |
Gene summary for CA7 |
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Gene information | Species | Human | Gene symbol | CA7 | Gene ID | 766 |
Gene name | carbonic anhydrase 7 | |
Gene Alias | CA-VII | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006730 | UniProtAcc | P43166 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
766 | CA7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.53e-07 | 7.95e-01 | -0.1954 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CA7 | SNV | Missense_Mutation | c.86N>A | p.Arg29His | p.R29H | P43166 | protein_coding | tolerated(0.08) | probably_damaging(0.918) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CA7 | SNV | Missense_Mutation | novel | c.278N>G | p.Lys93Arg | p.K93R | P43166 | protein_coding | tolerated(0.59) | benign(0.013) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CA7 | SNV | Missense_Mutation | c.110N>A | p.Ser37Tyr | p.S37Y | P43166 | protein_coding | tolerated(0.43) | possibly_damaging(0.827) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CA7 | SNV | Missense_Mutation | c.731N>A | p.Val244Glu | p.V244E | P43166 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-34-5239-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | taxotere | SD | |
CA7 | SNV | Missense_Mutation | novel | c.434T>A | p.Val145Glu | p.V145E | P43166 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-6842-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CA7 | SNV | Missense_Mutation | rs772935023 | c.712N>A | p.Asp238Asn | p.D238N | P43166 | protein_coding | deleterious(0) | benign(0.358) | TCGA-UF-A7JD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CA7 | SNV | Missense_Mutation | c.584N>T | p.Thr195Ile | p.T195I | P43166 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
CA7 | SNV | Missense_Mutation | c.86N>A | p.Arg29His | p.R29H | P43166 | protein_coding | tolerated(0.08) | probably_damaging(0.918) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CA7 | insertion | Frame_Shift_Ins | novel | c.449dupT | p.Leu150PhefsTer58 | p.L150Ffs*58 | P43166 | protein_coding | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CA7 | deletion | Frame_Shift_Del | c.443delN | p.Leu150TrpfsTer10 | p.L150Wfs*10 | P43166 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103434 | METHAZOLAMIDE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103455 | TOPIRAMATE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | activator | 135651493 | HISTAMINE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | activator | 178101506 | AMPHETAMINE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103398 | ACETAZOLAMIDE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | activator | 178100344 | HISTIDINE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103626 | ZONISAMIDE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103722 | CHLORTHALIDONE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178102147 | SULPIRIDE | |
766 | CA7 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103420 | ETHOXZOLAMIDE |
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