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Gene: C4orf33 |
Gene summary for C4ORF33 |
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Gene information | Species | Human | Gene symbol | C4orf33 | Gene ID | 132321 |
Gene name | chromosome 4 open reading frame 33 | |
Gene Alias | C4orf33 | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N1A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132321 | C4orf33 | LZE24T | Human | Esophagus | ESCC | 1.15e-06 | 1.22e-01 | 0.0596 |
132321 | C4orf33 | P1T-E | Human | Esophagus | ESCC | 9.83e-06 | 1.60e-01 | 0.0875 |
132321 | C4orf33 | P2T-E | Human | Esophagus | ESCC | 2.97e-12 | 1.47e-01 | 0.1177 |
132321 | C4orf33 | P4T-E | Human | Esophagus | ESCC | 7.48e-06 | 8.75e-02 | 0.1323 |
132321 | C4orf33 | P5T-E | Human | Esophagus | ESCC | 3.50e-02 | 4.13e-02 | 0.1327 |
132321 | C4orf33 | P11T-E | Human | Esophagus | ESCC | 3.13e-04 | 1.00e-01 | 0.1426 |
132321 | C4orf33 | P15T-E | Human | Esophagus | ESCC | 6.43e-07 | 3.69e-02 | 0.1149 |
132321 | C4orf33 | P17T-E | Human | Esophagus | ESCC | 1.86e-02 | 7.86e-02 | 0.1278 |
132321 | C4orf33 | P20T-E | Human | Esophagus | ESCC | 6.88e-09 | 9.05e-02 | 0.1124 |
132321 | C4orf33 | P21T-E | Human | Esophagus | ESCC | 8.17e-12 | 1.80e-01 | 0.1617 |
132321 | C4orf33 | P22T-E | Human | Esophagus | ESCC | 9.51e-03 | 8.80e-04 | 0.1236 |
132321 | C4orf33 | P23T-E | Human | Esophagus | ESCC | 2.74e-02 | 1.16e-01 | 0.108 |
132321 | C4orf33 | P24T-E | Human | Esophagus | ESCC | 1.15e-07 | 1.80e-01 | 0.1287 |
132321 | C4orf33 | P26T-E | Human | Esophagus | ESCC | 5.55e-13 | 1.85e-01 | 0.1276 |
132321 | C4orf33 | P27T-E | Human | Esophagus | ESCC | 6.22e-04 | 3.66e-02 | 0.1055 |
132321 | C4orf33 | P28T-E | Human | Esophagus | ESCC | 9.05e-04 | 6.58e-02 | 0.1149 |
132321 | C4orf33 | P31T-E | Human | Esophagus | ESCC | 1.16e-09 | 1.03e-01 | 0.1251 |
132321 | C4orf33 | P32T-E | Human | Esophagus | ESCC | 2.69e-12 | 1.96e-01 | 0.1666 |
132321 | C4orf33 | P36T-E | Human | Esophagus | ESCC | 1.18e-05 | 1.06e-01 | 0.1187 |
132321 | C4orf33 | P37T-E | Human | Esophagus | ESCC | 9.99e-07 | 2.49e-02 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf33 | SNV | Missense_Mutation | c.457N>G | p.Pro153Ala | p.P153A | Q8N1A6 | protein_coding | deleterious(0.01) | benign(0.385) | TCGA-BR-6455-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide phosphate | PD | |
C4orf33 | SNV | Missense_Mutation | c.474G>C | p.Gln158His | p.Q158H | Q8N1A6 | protein_coding | tolerated(0.11) | possibly_damaging(0.834) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C4orf33 | SNV | Missense_Mutation | novel | c.68N>C | p.Leu23Pro | p.L23P | Q8N1A6 | protein_coding | deleterious(0) | possibly_damaging(0.717) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
C4orf33 | SNV | Missense_Mutation | rs140576328 | c.523N>C | p.Asn175His | p.N175H | Q8N1A6 | protein_coding | tolerated(0.09) | benign(0) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
C4orf33 | insertion | Frame_Shift_Ins | novel | c.310_311insA | p.Ser104TyrfsTer40 | p.S104Yfs*40 | Q8N1A6 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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