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Gene: C22orf29 |
Gene summary for C22ORF29 |
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Gene information | Species | Human | Gene symbol | C22orf29 | Gene ID | 79680 |
Gene name | retrotransposon Gag like 10 | |
Gene Alias | BOP | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7L3V2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79680 | C22orf29 | P1T-E | Human | Esophagus | ESCC | 3.58e-07 | 2.50e-01 | 0.0875 |
79680 | C22orf29 | P2T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.49e-01 | 0.1177 |
79680 | C22orf29 | P4T-E | Human | Esophagus | ESCC | 1.49e-09 | 1.89e-01 | 0.1323 |
79680 | C22orf29 | P5T-E | Human | Esophagus | ESCC | 2.64e-08 | 1.48e-01 | 0.1327 |
79680 | C22orf29 | P8T-E | Human | Esophagus | ESCC | 1.64e-06 | 1.43e-01 | 0.0889 |
79680 | C22orf29 | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.49e-01 | 0.1131 |
79680 | C22orf29 | P10T-E | Human | Esophagus | ESCC | 5.29e-86 | 1.52e+00 | 0.116 |
79680 | C22orf29 | P11T-E | Human | Esophagus | ESCC | 3.75e-08 | 2.67e-01 | 0.1426 |
79680 | C22orf29 | P12T-E | Human | Esophagus | ESCC | 2.71e-09 | 2.42e-01 | 0.1122 |
79680 | C22orf29 | P15T-E | Human | Esophagus | ESCC | 1.53e-11 | 1.98e-01 | 0.1149 |
79680 | C22orf29 | P16T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.30e-01 | 0.1153 |
79680 | C22orf29 | P17T-E | Human | Esophagus | ESCC | 4.48e-07 | 2.57e-01 | 0.1278 |
79680 | C22orf29 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 1.90e-01 | 0.1662 |
79680 | C22orf29 | P20T-E | Human | Esophagus | ESCC | 3.20e-07 | 1.51e-01 | 0.1124 |
79680 | C22orf29 | P21T-E | Human | Esophagus | ESCC | 6.31e-42 | 7.88e-01 | 0.1617 |
79680 | C22orf29 | P22T-E | Human | Esophagus | ESCC | 3.88e-09 | 1.63e-01 | 0.1236 |
79680 | C22orf29 | P23T-E | Human | Esophagus | ESCC | 3.41e-22 | 4.23e-01 | 0.108 |
79680 | C22orf29 | P24T-E | Human | Esophagus | ESCC | 6.34e-04 | 1.02e-01 | 0.1287 |
79680 | C22orf29 | P26T-E | Human | Esophagus | ESCC | 6.42e-15 | 3.28e-01 | 0.1276 |
79680 | C22orf29 | P27T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.26e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C22orf29 | SNV | Missense_Mutation | novel | c.706G>A | p.Ala236Thr | p.A236T | Q7L3V2 | protein_coding | tolerated(0.2) | benign(0.045) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C22orf29 | SNV | Missense_Mutation | c.556N>T | p.Ala186Ser | p.A186S | Q7L3V2 | protein_coding | deleterious(0.02) | possibly_damaging(0.456) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
C22orf29 | SNV | Missense_Mutation | c.1082N>A | p.Ser361Tyr | p.S361Y | Q7L3V2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.387) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C22orf29 | SNV | Missense_Mutation | c.827C>A | p.Ser276Tyr | p.S276Y | Q7L3V2 | protein_coding | deleterious(0.01) | possibly_damaging(0.785) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C22orf29 | SNV | Missense_Mutation | rs745877517 | c.34C>T | p.Arg12Cys | p.R12C | Q7L3V2 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C22orf29 | SNV | Missense_Mutation | novel | c.371A>G | p.Tyr124Cys | p.Y124C | Q7L3V2 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
C22orf29 | SNV | Missense_Mutation | rs9618711 | c.35G>A | p.Arg12His | p.R12H | Q7L3V2 | protein_coding | tolerated_low_confidence(0.22) | benign(0.001) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C22orf29 | SNV | Missense_Mutation | novel | c.8N>A | p.Arg3His | p.R3H | Q7L3V2 | protein_coding | tolerated_low_confidence(0.57) | benign(0.003) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C22orf29 | SNV | Missense_Mutation | rs144116940 | c.508C>T | p.Leu170Phe | p.L170F | Q7L3V2 | protein_coding | tolerated(0.2) | benign(0.068) | TCGA-CC-A9FW-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
C22orf29 | SNV | Missense_Mutation | rs9618711 | c.35N>A | p.Arg12His | p.R12H | Q7L3V2 | protein_coding | tolerated_low_confidence(0.22) | benign(0.001) | TCGA-DD-AADC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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