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Gene: C20orf96 |
Gene summary for C20ORF96 |
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Gene information | Species | Human | Gene symbol | C20orf96 | Gene ID | 140680 |
Gene name | chromosome 20 open reading frame 96 | |
Gene Alias | dJ1103G7.2 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | B7ZML9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140680 | C20orf96 | LZE24T | Human | Esophagus | ESCC | 2.29e-10 | 2.90e-01 | 0.0596 |
140680 | C20orf96 | P1T-E | Human | Esophagus | ESCC | 6.07e-08 | 3.44e-01 | 0.0875 |
140680 | C20orf96 | P2T-E | Human | Esophagus | ESCC | 3.90e-10 | 1.30e-01 | 0.1177 |
140680 | C20orf96 | P4T-E | Human | Esophagus | ESCC | 9.37e-10 | 2.21e-01 | 0.1323 |
140680 | C20orf96 | P8T-E | Human | Esophagus | ESCC | 1.09e-08 | 7.84e-02 | 0.0889 |
140680 | C20orf96 | P10T-E | Human | Esophagus | ESCC | 9.99e-13 | 1.82e-01 | 0.116 |
140680 | C20orf96 | P12T-E | Human | Esophagus | ESCC | 5.31e-12 | 2.35e-01 | 0.1122 |
140680 | C20orf96 | P15T-E | Human | Esophagus | ESCC | 5.28e-03 | 4.80e-02 | 0.1149 |
140680 | C20orf96 | P16T-E | Human | Esophagus | ESCC | 6.13e-09 | 1.34e-01 | 0.1153 |
140680 | C20orf96 | P17T-E | Human | Esophagus | ESCC | 2.40e-05 | 2.33e-01 | 0.1278 |
140680 | C20orf96 | P20T-E | Human | Esophagus | ESCC | 1.72e-04 | 9.36e-02 | 0.1124 |
140680 | C20orf96 | P21T-E | Human | Esophagus | ESCC | 3.48e-11 | 1.15e-01 | 0.1617 |
140680 | C20orf96 | P22T-E | Human | Esophagus | ESCC | 1.14e-06 | 6.42e-02 | 0.1236 |
140680 | C20orf96 | P23T-E | Human | Esophagus | ESCC | 1.23e-10 | 2.14e-01 | 0.108 |
140680 | C20orf96 | P24T-E | Human | Esophagus | ESCC | 7.78e-05 | 4.71e-02 | 0.1287 |
140680 | C20orf96 | P26T-E | Human | Esophagus | ESCC | 3.37e-08 | 1.69e-01 | 0.1276 |
140680 | C20orf96 | P27T-E | Human | Esophagus | ESCC | 3.87e-11 | 1.95e-01 | 0.1055 |
140680 | C20orf96 | P28T-E | Human | Esophagus | ESCC | 3.76e-18 | 1.42e-01 | 0.1149 |
140680 | C20orf96 | P30T-E | Human | Esophagus | ESCC | 2.52e-03 | 1.12e-01 | 0.137 |
140680 | C20orf96 | P31T-E | Human | Esophagus | ESCC | 1.03e-04 | 1.22e-01 | 0.1251 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C20orf96 | SNV | Missense_Mutation | rs573549117 | c.751N>T | p.Arg251Cys | p.R251C | Q9NUD7 | protein_coding | tolerated(0.19) | benign(0.103) | TCGA-EI-6512-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folfox | SD |
C20orf96 | SNV | Missense_Mutation | novel | c.234G>T | p.Lys78Asn | p.K78N | Q9NUD7 | protein_coding | deleterious(0.01) | possibly_damaging(0.447) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C20orf96 | deletion | Frame_Shift_Del | c.488delN | p.Tyr163SerfsTer10 | p.Y163Sfs*10 | Q9NUD7 | protein_coding | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD | |||
C20orf96 | SNV | Missense_Mutation | novel | c.806N>G | p.Ile269Ser | p.I269S | Q9NUD7 | protein_coding | deleterious(0.05) | benign(0.277) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C20orf96 | SNV | Missense_Mutation | novel | c.606N>T | p.Glu202Asp | p.E202D | Q9NUD7 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C20orf96 | SNV | Missense_Mutation | novel | c.347N>A | p.Arg116Gln | p.R116Q | Q9NUD7 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C20orf96 | SNV | Missense_Mutation | novel | c.902N>T | p.Arg301Met | p.R301M | Q9NUD7 | protein_coding | tolerated(0.17) | benign(0.386) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C20orf96 | SNV | Missense_Mutation | c.543N>C | p.Glu181Asp | p.E181D | Q9NUD7 | protein_coding | tolerated(0.08) | possibly_damaging(0.879) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C20orf96 | SNV | Missense_Mutation | novel | c.63G>T | p.Gln21His | p.Q21H | Q9NUD7 | protein_coding | deleterious(0.03) | benign(0.202) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C20orf96 | SNV | Missense_Mutation | rs756968503 | c.955N>A | p.Glu319Lys | p.E319K | Q9NUD7 | protein_coding | deleterious(0.01) | benign(0.119) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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