![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C1QTNF6 |
Gene summary for C1QTNF6 |
![]() |
Gene information | Species | Human | Gene symbol | C1QTNF6 | Gene ID | 114904 |
Gene name | C1q and TNF related 6 | |
Gene Alias | CTFP6 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R1J0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114904 | C1QTNF6 | P2T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.43e-01 | 0.1177 |
114904 | C1QTNF6 | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 2.00e-01 | 0.1323 |
114904 | C1QTNF6 | P8T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.32e-01 | 0.0889 |
114904 | C1QTNF6 | P9T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.18e-01 | 0.1131 |
114904 | C1QTNF6 | P10T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.24e-01 | 0.116 |
114904 | C1QTNF6 | P11T-E | Human | Esophagus | ESCC | 1.85e-29 | 1.14e+00 | 0.1426 |
114904 | C1QTNF6 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.38e-01 | 0.1278 |
114904 | C1QTNF6 | P19T-E | Human | Esophagus | ESCC | 1.65e-10 | 6.70e-01 | 0.1662 |
114904 | C1QTNF6 | P21T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.39e-01 | 0.1617 |
114904 | C1QTNF6 | P22T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.07e-01 | 0.1236 |
114904 | C1QTNF6 | P24T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.69e-01 | 0.1287 |
114904 | C1QTNF6 | P26T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.03e-01 | 0.1276 |
114904 | C1QTNF6 | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.12e-01 | 0.1666 |
114904 | C1QTNF6 | P37T-E | Human | Esophagus | ESCC | 5.50e-16 | 3.45e-01 | 0.1371 |
114904 | C1QTNF6 | P40T-E | Human | Esophagus | ESCC | 1.20e-04 | 2.19e-01 | 0.109 |
114904 | C1QTNF6 | P42T-E | Human | Esophagus | ESCC | 2.42e-06 | 2.63e-01 | 0.1175 |
114904 | C1QTNF6 | P44T-E | Human | Esophagus | ESCC | 1.67e-06 | 4.07e-01 | 0.1096 |
114904 | C1QTNF6 | P47T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.28e-01 | 0.1067 |
114904 | C1QTNF6 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 5.95e-01 | 0.1768 |
114904 | C1QTNF6 | P52T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.09e-01 | 0.1555 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QTNF6 | SNV | Missense_Mutation | rs757482131 | c.781N>A | p.Asp261Asn | p.D261N | Q9BXI9 | protein_coding | tolerated(0.12) | benign(0.09) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QTNF6 | SNV | Missense_Mutation | novel | c.680N>T | p.Ser227Ile | p.S227I | Q9BXI9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QTNF6 | SNV | Missense_Mutation | novel | c.173N>A | p.Arg58Gln | p.R58Q | Q9BXI9 | protein_coding | tolerated(0.08) | benign(0.284) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QTNF6 | SNV | Missense_Mutation | rs775910598 | c.172N>T | p.Arg58Trp | p.R58W | Q9BXI9 | protein_coding | deleterious(0.04) | benign(0.169) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QTNF6 | SNV | Missense_Mutation | c.814C>T | p.Leu272Phe | p.L272F | Q9BXI9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C1QTNF6 | SNV | Missense_Mutation | novel | c.362N>A | p.Gly121Asp | p.G121D | Q9BXI9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C1QTNF6 | insertion | Frame_Shift_Ins | novel | c.634_635insGAGG | p.Asn212ArgfsTer96 | p.N212Rfs*96 | Q9BXI9 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C1QTNF6 | deletion | Frame_Shift_Del | novel | c.241delN | p.His81ThrfsTer15 | p.H81Tfs*15 | Q9BXI9 | protein_coding | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD | ||
C1QTNF6 | insertion | Frame_Shift_Ins | novel | c.237_238insG | p.Pro80AlafsTer6 | p.P80Afs*6 | Q9BXI9 | protein_coding | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C1QTNF6 | SNV | Missense_Mutation | novel | c.352N>T | p.Gly118Trp | p.G118W | Q9BXI9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |