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Gene: C19orf43 |
Gene summary for C19ORF43 |
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Gene information | Species | Human | Gene symbol | C19orf43 | Gene ID | 79002 |
Gene name | telomerase RNA component interacting RNase | |
Gene Alias | C19orf43 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7EN60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79002 | C19orf43 | GSM4909280 | Human | Breast | Precancer | 2.22e-02 | -4.13e-01 | 0.0305 |
79002 | C19orf43 | GSM4909281 | Human | Breast | IDC | 1.24e-19 | -4.13e-01 | 0.21 |
79002 | C19orf43 | GSM4909282 | Human | Breast | IDC | 2.31e-20 | -4.13e-01 | -0.0288 |
79002 | C19orf43 | GSM4909285 | Human | Breast | IDC | 1.24e-19 | -4.13e-01 | 0.21 |
79002 | C19orf43 | GSM4909286 | Human | Breast | IDC | 6.58e-19 | -4.13e-01 | 0.1081 |
79002 | C19orf43 | GSM4909287 | Human | Breast | IDC | 4.10e-23 | -4.13e-01 | 0.2057 |
79002 | C19orf43 | GSM4909288 | Human | Breast | IDC | 1.48e-05 | -4.13e-01 | 0.0988 |
79002 | C19orf43 | GSM4909289 | Human | Breast | IDC | 6.81e-04 | -4.13e-01 | 0.1064 |
79002 | C19orf43 | GSM4909290 | Human | Breast | IDC | 1.25e-16 | -4.13e-01 | 0.2096 |
79002 | C19orf43 | GSM4909291 | Human | Breast | IDC | 1.61e-13 | -4.13e-01 | 0.1753 |
79002 | C19orf43 | GSM4909293 | Human | Breast | IDC | 5.35e-20 | -4.13e-01 | 0.1581 |
79002 | C19orf43 | GSM4909294 | Human | Breast | IDC | 2.31e-20 | -4.13e-01 | 0.2022 |
79002 | C19orf43 | GSM4909295 | Human | Breast | IDC | 1.15e-10 | -4.13e-01 | 0.0898 |
79002 | C19orf43 | GSM4909296 | Human | Breast | IDC | 5.35e-20 | -4.13e-01 | 0.1524 |
79002 | C19orf43 | GSM4909297 | Human | Breast | IDC | 1.82e-21 | -4.13e-01 | 0.1517 |
79002 | C19orf43 | GSM4909298 | Human | Breast | IDC | 9.92e-21 | -4.13e-01 | 0.1551 |
79002 | C19orf43 | GSM4909299 | Human | Breast | IDC | 6.58e-19 | -4.13e-01 | 0.035 |
79002 | C19orf43 | GSM4909300 | Human | Breast | IDC | 1.97e-09 | -4.13e-01 | 0.0334 |
79002 | C19orf43 | GSM4909301 | Human | Breast | IDC | 2.31e-20 | -4.13e-01 | 0.1577 |
79002 | C19orf43 | GSM4909302 | Human | Breast | IDC | 8.69e-23 | -4.13e-01 | 0.1545 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf43 | SNV | Missense_Mutation | rs747584062 | c.355C>T | p.Arg119Cys | p.R119C | Q9BQ61 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C19orf43 | SNV | Missense_Mutation | novel | c.410N>C | p.Lys137Thr | p.K137T | Q9BQ61 | protein_coding | deleterious(0.03) | possibly_damaging(0.728) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C19orf43 | SNV | Missense_Mutation | c.188N>A | p.Gly63Asp | p.G63D | Q9BQ61 | protein_coding | tolerated(0.05) | possibly_damaging(0.873) | TCGA-G3-A5SI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
C19orf43 | SNV | Missense_Mutation | novel | c.397G>T | p.Ala133Ser | p.A133S | Q9BQ61 | protein_coding | deleterious(0.01) | possibly_damaging(0.747) | TCGA-55-7574-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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