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Gene: C16orf58 |
Gene summary for C16ORF58 |
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Gene information | Species | Human | Gene symbol | C16orf58 | Gene ID | 64755 |
Gene name | RUS family member 1 | |
Gene Alias | C16orf58 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024QZE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64755 | C16orf58 | LZE4T | Human | Esophagus | ESCC | 5.33e-03 | 6.08e-02 | 0.0811 |
64755 | C16orf58 | LZE7T | Human | Esophagus | ESCC | 3.16e-04 | 1.50e-01 | 0.0667 |
64755 | C16orf58 | LZE8T | Human | Esophagus | ESCC | 1.23e-04 | 9.74e-02 | 0.067 |
64755 | C16orf58 | LZE20T | Human | Esophagus | ESCC | 5.76e-07 | 1.27e-01 | 0.0662 |
64755 | C16orf58 | LZE22D1 | Human | Esophagus | HGIN | 1.10e-04 | 1.38e-01 | 0.0595 |
64755 | C16orf58 | LZE24T | Human | Esophagus | ESCC | 8.43e-15 | 3.86e-01 | 0.0596 |
64755 | C16orf58 | LZE21T | Human | Esophagus | ESCC | 9.04e-04 | 2.19e-01 | 0.0655 |
64755 | C16orf58 | P1T-E | Human | Esophagus | ESCC | 2.02e-12 | 3.83e-01 | 0.0875 |
64755 | C16orf58 | P2T-E | Human | Esophagus | ESCC | 3.93e-32 | 6.40e-01 | 0.1177 |
64755 | C16orf58 | P4T-E | Human | Esophagus | ESCC | 2.95e-11 | 1.86e-01 | 0.1323 |
64755 | C16orf58 | P5T-E | Human | Esophagus | ESCC | 5.62e-08 | 1.41e-01 | 0.1327 |
64755 | C16orf58 | P8T-E | Human | Esophagus | ESCC | 5.52e-20 | 2.14e-01 | 0.0889 |
64755 | C16orf58 | P9T-E | Human | Esophagus | ESCC | 8.23e-05 | 1.01e-01 | 0.1131 |
64755 | C16orf58 | P10T-E | Human | Esophagus | ESCC | 1.94e-20 | 2.61e-01 | 0.116 |
64755 | C16orf58 | P11T-E | Human | Esophagus | ESCC | 6.32e-13 | 3.97e-01 | 0.1426 |
64755 | C16orf58 | P12T-E | Human | Esophagus | ESCC | 5.66e-24 | 4.99e-01 | 0.1122 |
64755 | C16orf58 | P15T-E | Human | Esophagus | ESCC | 2.95e-20 | 3.24e-01 | 0.1149 |
64755 | C16orf58 | P16T-E | Human | Esophagus | ESCC | 3.37e-24 | 4.40e-01 | 0.1153 |
64755 | C16orf58 | P17T-E | Human | Esophagus | ESCC | 1.03e-08 | 3.34e-01 | 0.1278 |
64755 | C16orf58 | P19T-E | Human | Esophagus | ESCC | 7.06e-06 | 2.95e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf58 | SNV | Missense_Mutation | rs775036191 | c.820N>A | p.Ala274Thr | p.A274T | Q96GQ5 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | novel | c.160N>A | p.Gly54Arg | p.G54R | Q96GQ5 | protein_coding | tolerated(0.31) | benign(0.013) | TCGA-B5-A11L-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C16orf58 | SNV | Missense_Mutation | novel | c.1169N>T | p.Ala390Val | p.A390V | Q96GQ5 | protein_coding | tolerated(0.25) | benign(0.079) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | novel | c.1000N>T | p.His334Tyr | p.H334Y | Q96GQ5 | protein_coding | tolerated(0.17) | benign(0.059) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | rs185844277 | c.646N>A | p.Val216Met | p.V216M | Q96GQ5 | protein_coding | tolerated(1) | benign(0.013) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | rs866827880 | c.1144G>A | p.Ala382Thr | p.A382T | Q96GQ5 | protein_coding | tolerated(0.29) | possibly_damaging(0.548) | TCGA-D1-A17F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C16orf58 | SNV | Missense_Mutation | novel | c.761C>T | p.Ser254Leu | p.S254L | Q96GQ5 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
C16orf58 | SNV | Missense_Mutation | rs185844277 | c.646N>A | p.Val216Met | p.V216M | Q96GQ5 | protein_coding | tolerated(1) | benign(0.013) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C16orf58 | SNV | Missense_Mutation | novel | c.637G>T | p.Ala213Ser | p.A213S | Q96GQ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.781) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
C16orf58 | SNV | Missense_Mutation | c.1226G>T | p.Arg409Leu | p.R409L | Q96GQ5 | protein_coding | tolerated(0.73) | benign(0) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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